Frontiers Between Attention Deficit Hyperactivity Disorder and Bipolar Disorder

Galanter, Cathryn A.; Leibenluft, Ellen

doi:10.1016/j.chc.2007.11.001

Cited by 94 publications

(83 citation statements)

References 87 publications

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“…However, when they fi nd some diffi culty, they fail to overcome it to reach their goal. This lack of fl exibility leads to frustration, and perhaps can explain the outbursts of irritability and aggressiveness characteristic of this disorder (Galanter & Leibenluft, 2008;Geller et al, 2004Geller et al, , 1998Leibenluft et al, 2003). When evaluating children/adolescents as informants the present study did not fi nd any defi cits in EF in children/ adolescents with symptoms of PBD.…”

Section: Phenotype Of Pbdmentioning

confidence: 53%

“…Relaying on the diagnostic criteria of unspecifi ed bipolar disorder from the DSM-IV-TR (APA, 2000) and those given by Leibenluft et al (2003) for the broad phenotype of youth mania. The unspecifi ed bipolar disorder refers to a broad category that includes symptoms that do not meet the threshold necessary to be considered a diagnostic criterion, and which may include extreme symptoms of irritability and emotional lability presented by these children and adolescents (Galanter & Leibenluft, 2008). Leibenluft et al (2003) and Serra Giacobo, Jané, Bonillo, Ballespí and Díaz-Regañon (2012) take the same notion of broad phenotype or Severe Mood and Behavioural Dysregulation to refer to children who have a chronic non-episodic illness (mania-depression), without the characteristic symptoms of hypomania, but show persistent symptoms of irritability and hyperarousal.…”

Section: Broad Phenotype Of Paediatric Bipolar Disordermentioning

confidence: 99%

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Executive Function Associated to Symptoms of Attention Deficit Hyperactivity Disorder and Paediatric Bipolar Disorder

Jiménez¹,

Ballabriga²,

Martín³

et al. 2015

Psicol. Reflex. Crit.

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Very little is known about the differences of the neurocognitive functioning of Attention Defi cit Hyperactivity Disorder (ADHD) and Paediatric Bipolar Disorder (PBD), since current studies do not agree on a differentiation of Executive Function (EF) between the two disorders. The aim of this study was to determine the EF defi cits associated with symptomatology of ADHD and the PBD phenotype. Participants were 76 children/adolescents aged 6-17 years and their parents, submitted to a diagnostic interview and a tool for assessing EF, Behaviour Rating Inventory of Executive Function. Structural Equation Modeling was used to examine associations between symptoms of ADHD and the PBD phenotype, and the EF. A model for parents and a model for children/ adolescents were performed. The model indexes showed a satisfactory fi t. ADHD was found to be associated with defi cits in all areas of EF, especially when the predominant symptom is inattention. The presence of symptoms of PBD phenotype was associated only with diffi culties in fi nding new strategies to solve problems and inhibiting new behaviour. The article concluded that the presence of ADHD symptoms is associated with cognitive defi cits different from those that may occur with PBD symptoms. It is advisable that professionals consider patients' neurocognitive profi les in order to achieve an appropriate differential diagnosis. Keywords: Executive function, attention defi cit hyperactivity disorder, paediatric bipolar disorder. ResumoAinda é pouco o que se sabe do funcionamento do Transtorno de Défi cit de Atenção/Hiperatividade (TDAH) e do Transtorno Bipolar Pediátrico (TBP), já que atualmente os investigadores não concordam quanto a uma diferenciação da Função Executiva (FE) nos dois transtornos. O objetivo deste estudo é determinar os défi cits da FE associados às sintomatologias de TDAH e do fenótipo do TBP. Foram avaliados 76 crianças/adolescentes com idades entre 6-17 anos e seus pais, com uma entrevista diagnóstica e um instrumento para avaliação da FE, Behaviour Rating Inventory of Executive Function. Modelos de equações estruturais foram usados para examinar associações entre a sintomatologia de TDAH e do fenótipo de TBP, e a FE. Foi realizado um modelo para pais e outro para crianças/adolescentes. Os índices do modelo indicaram um ajuste satisfatório. Foi encontrado que o TDAH está associado a defi ciências em todas as áreas da FE, sobretudo se a sintomatologia predominante é a desatenção. A presença de sintomatologia do fenótipo de TBP somente apresentou associação a difi culdades na busca de novas estratégias na solução de problemas e na inibição de novas condutas. Conclui-se que a presença de sintomatologia de TDAH está associada a defi ciências cognitivas diferentes das que podem estar presentes no TBP. É recomendável que os profi ssionais considerem o perfi l neurocognitivo de seus pacientes para alcançarem um diagnóstico diferencial adequado. Palavras-chave: Função executiva, transtorno de défi cit de atenção/hiperatividade, transtorno bipol...

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Section: Phenotype Of Pbdmentioning

confidence: 53%

Section: Broad Phenotype Of Paediatric Bipolar Disordermentioning

confidence: 99%

Executive Function Associated to Symptoms of Attention Deficit Hyperactivity Disorder and Paediatric Bipolar Disorder

Jiménez¹,

Ballabriga²,

Martín³

et al. 2015

Psicol. Reflex. Crit.

View full text Add to dashboard Cite

show abstract

“…It is, unfortunately, difficult to support . Other disorders can present with symptoms superficially resembling bipolarity, as with the emotional and behavioural dysregulation of BPD (Paris et al, 2007), the pressured thinking of severe anxiety disorders (Provencher et al, 2012) or the distractibility and impulsivity of ADHD (Galanter and Leibenluft, 2008), and these disorders can also occur in the absence of bipolarity.…”

Section: Specificity Of 'Soft Bipolarity'mentioning

confidence: 99%

Why is soft bipolar disorder so hard to define?

Kuiper

Curran

Malhi

2012

Aust N Z J Psychiatry

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“…The need for treatment of the comorbid anxiety disorders was stressed, both to improve the anxiety and to prevent worsening of the BD. 26 Controversies abound on the links between ADHD and BD, where some child psychiatrists claim very high rates of comorbidity 27 and adult bipolar specialists observe much lower rates. 28 The first consecutive 1000 adults in STEP-BD were assessed for lifetime ADHD in conjunction with the retrospective course of BD, current mood state, and prevalence of other comorbid psychiatric diagnoses.…”

Section: Comorbidity With Other Psychiatric Disordersmentioning

confidence: 99%

Advancing Bipolar Disorder: Key Lessons from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

2010

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W La Revue canadienne de psychiatrie, vol 55, no 3, mars 2010 136Objective: To review the overall clinical research findings from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), the world's largest study of BD.Methods: STEP-BD was conducted from 1998 to 2005, enrolling participants (n = 4361) across 22 clinical sites in the United States. Each individual was followed for up to 2 years in naturalistic practice with blinded research assessments, while subgroups participated in randomized controlled trials (RCTs) for bipolar depression. The naturalistic database was used to examine the course of BD, comorbidity with other psychiatric disorders, and suicidality. Relevant studies in English, published from January 1, 1994, to May 31, 2009, were identified using computerized searches of electronic databases (PubMed, PsycINFO, and Cochrane Register of Clinical Trials), inspection of bibliographies, and review of other major reports. Results:One large RCT involving the addition of either paroxetine or bupropion to mood stabilizers in acute depression found neither more effective than placebo in achieving sustained recovery (8 weeks of euthymia). A second large RCT found intensive psychosocial interventions superior to a brief psychosocial intervention as an adjunct to medication in acute depression. A third small RCT found minimal effects of lamotrigine, risperidone, or inositol in refractory depression. Recovery was difficult to achieve, with subsyndromal symptoms or full relapse very common. Anxiety disorders and smoking in particular were treatable conditions that adversely affected the course of BD.Conclusions: STEP-BD yielded numerous clinical and systems observations that provide fresh direction for research and treatment of BD, including setting new benchmarks for outcome and demonstrating the viability of large BD networks.Can J Psychiatry. 2010;55(3):136-143. Highlights· STEP-BD was the largest BD research program ever conducted, and included data from 3 major RCTs and findings from many observational studies. · Few treatments were successful in bipolar depression, with psychosocial interventions combined with mood stabilizers the most positive. · Comorbidity of BD with substance abuse and smoking were common and adversely affected clinical outcome, while comorbidity with adult attention-deficit hyperactivity disorder was modest.

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Frontiers Between Attention Deficit Hyperactivity Disorder and Bipolar Disorder

Cited by 94 publications

References 87 publications

Executive Function Associated to Symptoms of Attention Deficit Hyperactivity Disorder and Paediatric Bipolar Disorder

Executive Function Associated to Symptoms of Attention Deficit Hyperactivity Disorder and Paediatric Bipolar Disorder

Why is soft bipolar disorder so hard to define?

Advancing Bipolar Disorder: Key Lessons from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

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