Frontiers and hotspots evolution in anti-inflammatory studies for coronary heart disease: A bibliometric analysis of 1990–2022

Zhang, Jia-le; Ji, Chenyang; Xu, Zeng‐Guang; Tong, Hongxuan; Hu, Jingqing

doi:10.3389/fcvm.2023.1038738

Cited by 5 publications

(7 citation statements)

References 176 publications

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“…Inflammatory response and oxidative stress are important common links. The inflammatory response is activated in both diseases, leading to increased production of inflammatory cytokines ( 52 ). These cytokines include tumor necrosis factor-α (TNF-α) ( 53 ), interleukin-1β (IL-1β) ( 54 ), and interleukin-6 (IL-6) ( 55 ), among others, which are involved in the inflammatory response of the vascular wall and damage to vascular endothelial cells ( 56 ).…”

Section: The Common Relationship Between Dn and Panvascular Diseasementioning

confidence: 99%

Unveiling the pathogenesis and therapeutic approaches for diabetic nephropathy: insights from panvascular diseases

Zhang,

Ren

et al. 2024

Front. Endocrinol.

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Diabetic nephropathy (DN) represents a significant microvascular complication in diabetes, entailing intricate molecular pathways and mechanisms associated with cardiorenal vascular diseases. Prolonged hyperglycemia induces renal endothelial dysfunction and damage via metabolic abnormalities, inflammation, and oxidative stress, thereby compromising hemodynamics. Concurrently, fibrotic and sclerotic alterations exacerbate glomerular and tubular injuries. At a macro level, reciprocal communication between the renal microvasculature and systemic circulation establishes a pernicious cycle propelling disease progression. The current management approach emphasizes rigorous control of glycemic levels and blood pressure, with renin-angiotensin system blockade conferring renoprotection. Novel antidiabetic agents exhibit renoprotective effects, potentially mediated through endothelial modulation. Nonetheless, emerging therapies present novel avenues for enhancing patient outcomes and alleviating the disease burden. A precision-based approach, coupled with a comprehensive strategy addressing global vascular risk, will be pivotal in mitigating the cardiorenal burden associated with diabetes.

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Section: The Common Relationship Between Dn and Panvascular Diseasementioning

confidence: 99%

Unveiling the pathogenesis and therapeutic approaches for diabetic nephropathy: insights from panvascular diseases

Zhang,

Ren

et al. 2024

Front. Endocrinol.

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“…Evidence has accumulated indicating the significant relevance of low-grade inflammatory processes to cardiovascular disease, cancer and vascular risk factors ( 1 , 4 ). Further, high sensitivity C-reactive protein (hs-CRP) is a strong independent predictor of future cardiovascular events ( 3 , 5 ). Cohort studies have shown that elevated CRP is associated with mortality and cardiovascular disease (CVD) events for patients with various CVD locations like coronary artery disease, cerebrovascular disease, peripheral artery disease, and abdominal aortic aneurysm ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…Systemic inflammation is associated with the development and progression of many chronic conditions, cardiovascular (CVD), metabolic, renal and oncologic diseases, as well as morbidity and mortality (1)(2)(3). Evidence has accumulated indicating the significant relevance of low-grade inflammatory processes to cardiovascular disease, cancer and vascular risk factors (1,4).…”

Section: Introductionmentioning

confidence: 99%

Inflammation and poverty as individual and combined predictors of 15-year mortality risk in middle aged and older adults in the US

Mainous,

Orlando,

Yin

et al. 2024

Front. Med.

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BackgroundChronic systemic inflammation and poverty are both linked to an increased mortality risk. The goal of this study was to determine if there is a synergistic effect of the presence of inflammation and poverty on the 15-year risk of all-cause, heart disease and cancer mortality among US adults.MethodsWe analyzed the nationally representative National Health and Nutrition Examination Survey (NHANES) 1999 to 2002 with linked records to the National Death Index through the date December 31, 2019. Among adults aged 40 and older, 15-year mortality risk associated with inflammation, C-reactive protein (CRP), and poverty was assessed in Cox regressions. All-cause, heart disease and cancer mortality were the outcomes.ResultsIndividuals with elevated CRP at 1.0 mg/dL and poverty were at greater risk of 15-year adjusted, all-cause mortality (HR = 2.45; 95% CI 1.64, 3.67) than individuals with low CRP and were above poverty. For individuals with just one at risk characteristic, low inflammation/poverty (HR = 1.58; 95% CI 1.30, 1.93), inflammation/above poverty (HR = 1.59; 95% CI 1.31, 1.93) the mortality risk was essentially the same and substantially lower than the risk for adults with both. Individuals with both elevated inflammation and living in poverty experience a 15-year heart disease mortality risk elevated by 127% and 15-year cancer mortality elevated by 196%.DiscussionThis study extends the past research showing an increased mortality risk for poverty and systemic inflammation to indicate that there is a potential synergistic effect for increased mortality risk when an adult has both increased inflammation and is living in poverty.

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“…Evidence has accumulated indicating the significant relevance of low-grade inflammatory processes to cardiovascular disease, cancer and vascular risk factors ( 4 , 7 ). Further, hs-CRP is a strong independent predictor of future cardiovascular events ( 6 , 8 ). Cohort studies have shown that elevated CRP is associated with mortality and cardiovascular disease (CVD) events for patients with various CVD locations like coronary artery disease, cerebrovascular disease, peripheral artery disease, and abdominal aortic aneurysm ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…Systemic inflammation is associated with the development and progression of many chronic conditions like atherosclerosis, diabetes, hypertension, hyperlipidemia, and obesity, as well as morbidity and mortality (4)(5)(6). Figure 1 presents a pathway.…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammation among adults with diagnosed and undiagnosed cardiometabolic conditions: a potential missed opportunity for cardiovascular disease prevention

Mainous,

Sharma,

2024

Front. Med.

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ContextSystemic inflammation is associated with cardiovascular morbidity and mortality. Since inflammation is not screened in the population, the prevalence, particularly among individuals with undiagnosed cardiometabolic disease, is unclear.ObjectiveTo assess the prevalence of elevated inflammation using high sensitivity C-reactive protein (hs-CRP) (>0.30 mg/dL) in adults with no cardiometabolic disease, undiagnosed disease and diagnosed disease.MethodsWe conducted a cross-sectional analysis of the 2015–2020 National Health and Nutrition Examination Survey which allows for population estimates of the US population. Adults > = 20 years old were included. HsCRP levels >0.30 mg/dL represented inflammation. Individuals were classified into disease defined as having one or more of the following: diagnosed disease--diabetes, hypertension, hyperlipidemia, or obesity by diagnosis; undiagnosed disease (self-report of no doctor diagnosis but positive biomarker); no disease.Results12,946 unweighted individuals representing 315,354,183 adults in the US population were assessed. The proportion of adults with systemic inflammation is 34.63%. The proportion of individuals aged 20 years and older with no disease, undiagnosed disease and diagnosed disease and inflammation was 15.1, 29.1 and 41.8%, respectively. When stratifying by race/ethnicity among individuals with elevated inflammation Non-Hispanic Black people have the highest prevalence (50.35%) in individuals with diagnosed disease followed by Hispanics (46.13%) and Non-Hispanic White people (40.15%) (p < 0.01). In logistic regressions adjusted for sociodemographic variables, individuals with undiagnosed cardiometabolic disease have an increased risk of elevated inflammation as measured by CRP (OR 2.38; 95%CI = 1.90–2.99).ConclusionIn conclusion, a substantial proportion of the adult population, particularly minority and low socioeconomic populations, have elevated inflammation. Systemic inflammation may be a potential focus for disease prevention and disease progression in primary care.

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Frontiers and hotspots evolution in anti-inflammatory studies for coronary heart disease: A bibliometric analysis of 1990–2022

Cited by 5 publications

References 176 publications

Unveiling the pathogenesis and therapeutic approaches for diabetic nephropathy: insights from panvascular diseases

Unveiling the pathogenesis and therapeutic approaches for diabetic nephropathy: insights from panvascular diseases

Inflammation and poverty as individual and combined predictors of 15-year mortality risk in middle aged and older adults in the US

Systemic inflammation among adults with diagnosed and undiagnosed cardiometabolic conditions: a potential missed opportunity for cardiovascular disease prevention

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