Frontal white matter volume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease

Babiloni, Claudio; Frisoni, Giovanni B.; Steriade, Mircea; Bresciani, Lorenzo; Binetti, Giuliano; Percio, Claudio Del; Geroldi, Cristina; Miniussi, Carlo; Nobili, Flavio; Rodriguez, Guido; Zappasodi, Filippo; Carfagna, Tania; Rossini, Paolo Maria

doi:10.1016/j.clinph.2006.01.020

Cited by 154 publications

(135 citation statements)

References 155 publications

(195 reference statements)

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“…Delayed onset and recovery of EEG during recovery from CNS disease has been observed for example in case of herpes simplex infections (Upton and Gumpert, 1970;Illis and Taylor, 1972). In additional, albeit indirect, support of our hypothesis, frontal white matter volume and amplitude of resting delta EEG oscillations (1.5-4 Hz) show negative correlation in patients with mild cognitive impairment and Alzheimer's disease (Fernandez et al, 2003;Babiloni et al, 2006). Little progress has been made in the debate about the nature of periodic discharge types and mechanisms (Chong and Hirsch, 2005;Hirsch et al, 2005;Jirsch and Hirsch, 2007).…”

Section: Discussionsupporting

confidence: 79%

Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex

Fröhlich¹,

Bazhenov²,

Sejnowski³

2008

J. Neurosci.

102

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Slow periodic EEG discharges are common in CNS disorders. The pathophysiology of this aberrant rhythmic activity is poorly understood. We used a computational model of a neocortical network with a dynamic homeostatic scaling rule to show that loss of input (partial deafferentation) can trigger network reorganization that results in pathological periodic discharges. The decrease in average firing rate in the network by deafferentation was compensated by homeostatic synaptic scaling of recurrent excitation among pyramidal cells. Synaptic scaling succeeded in recovering the network target firing rate for all degrees of deafferentation (fraction of deafferented cells), but there was a critical degree of deafferentation for pathological network reorganization. For deafferentation degrees below this value, homeostatic upregulation of recurrent excitation had minimal effect on the macroscopic network dynamics. For deafferentation above this threshold, however, a slow periodic oscillation appeared, patterns of activity were less sparse, and bursting occurred in individual neurons. Also, comparison of spike-triggered afferent and recurrent excitatory conductances revealed that information transmission was strongly impaired. These results suggest that homeostatic plasticity can lead to secondary functional impairment in case of cortical disorders associated with cell loss.

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Section: Discussionsupporting

confidence: 79%

Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex

Fröhlich¹,

Bazhenov²,

Sejnowski³

2008

J. Neurosci.

102

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“…Significant negative correlation exists between the amount of lobar white matter and delta but not theta activity across the continuum of subjects with mild cognitive impairment and Alzheimers' dementia (Babiloni et al, 2006b). However, regional theta power correlates positively to the volume of cerebral edema around brain lesions (Fernandez-Bouzas et al, 1997) and negatively to hippocampal volumes in Alzheimer's disease (Grunwald et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Theta EEG source localization using LORETA in partial epilepsy patients with and without medication

Clemens

Bessenyei

Fekete

et al. 2010

Clinical Neurophysiology

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Objective. To investigate and localize the sources of spontaneous, scalp-recorded theta activity in patients with partial epilepsy (PE).Methods. 9 patients with beginning, untreated PE (Group1), 31 patients with already treated PE (Group2), and 14 healthy persons were investigated by means of spectral analysis and LORETA, low resolution electromagnetic tomography (1 Hz very narrow band analysis, age-adjusted, Z-scored values). The frequency of main interest was 4 to 8 Hz Results. Group analysis. Group1 displayed bilateral theta maxima in the temporal theta area (TTA), parietal theta area (PTA), and frontal theta area (FTA). In Group2, theta activity increased all over the scalp as compared to the normative mean (Z=0) and also to Group1. Maximum activity was found in the TTA, PTA, and FTA. However, in the PTA and FTA the centers of the abnormality shifted towards the medial cortex. Individual analysis: all the patients showed preferential activation (maximum Zvalues) within one of the three theta areas. 2Conclusion. EEG activity in the theta band is increased in anatomically meaningful patterns in PE patients, which differs from the anatomical distribution of theta in healthy persons.Significance. The findings contribute to our understanding of the sources of theta rhythms and the pathophysiology of PE.

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“…Deursen et al [14] observed an increased power of low frequencies band (delta and theta) and decreased power of higher frequencies band (alpha and beta) in AD. Babiloni et al [15,16] reported increased power of delta band and decreased power of alpha band in fronto-central region in Mild Cognitive Impairment (MCI) and AD subjects. When compared to normal elderly subjects, patients with Alzheimer's disease have shown a power increase of topographically widespread delta and theta rhythms and a power decrease of posterior alpha (8-13 Hz) and beta (13-30 Hz) rhythms [17,18] .…”

Section: Resultsmentioning

confidence: 99%

“…Electrical brain activity has been described following a wave pattern consisting of different types of frequency bands, namely delta (0-4 Hz), theta (4-8 Hz), alpha (8-13Hz), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and gamma (30-50Hz) waves [11] .In this context the present study was undertaken to explore neural dynamics as patterned through EEG rhythm and to appreciate an insight into the functioning of human mind in relation to cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

EEG Pattern in Alzheimer’s Disease at Resting Condition

Soni¹

2017

JMSCR

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Frontal white matter volume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease

Abstract: The present findings support, at least at group level, the 'transition hypothesis' of brain structural and functional continuity between MCI and AD.

Cited by 154 publications

References 155 publications

Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex

Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex

Theta EEG source localization using LORETA in partial epilepsy patients with and without medication

EEG Pattern in Alzheimer’s Disease at Resting Condition

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