Frontal white matter hyperintensity predicts lower urinary tract dysfunction in older adults with amnestic mild cognitive impairment and <scp>A</scp>lzheimer's disease

Ogama, Noriko; Yoshida, Masaki; Nakai, Toshiharu; Niida, Shumpei; Toba, Kenji; Sakurai, Takashi

doi:10.1111/ggi.12447

Cited by 30 publications

(44 citation statements)

References 21 publications

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“…Arterial stiffness has been found to be associated with structural changes in the brain, primarily white matter hyperintensities, cerebral lacunar infarction, and cortical brain atrophy 22,23) . Regarding regional differences, cross-sectional and longitudinal studies showed that structural changes, such as white matter hyperintensities and lacunes, progressed with age, mainly in the frontal and parietal lobes 24,25) . Increased arterial stiffness was also associated with increased lesions mainly in the frontal lobe 26) .…”

Section: Discussionmentioning

confidence: 99%

Association between the Cardio-Ankle Vascular Index and Executive Function in Community-Dwelling Elderly People

Sugimoto

Misu

Sawa

et al. 2016

JAT

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Aim:The aim of this study was to investigate the cross-sectional association between arterial stiffness (AS) measured with the cardio-ankle vascular index (CAVI) and executive function in communitydwelling elderly people. Methods: Subjects were 140 community-dwelling elderly people who participated in the study at Kobe, Japan during the period of August-September 2014, of which 126 (mean age SD: 73.2 6.1, female: 67.5%) met the inclusion criteria and completed the study. Age, sex, body mass index, global cognition, existence of chronic disease, medication, smoking history, and years of education were assessed. The degree of AS was assessed using CAVI. Executive function was assessed using the Category Word Fluency Test (CWFT), Letter Word Fluency Test (LWFT), and Digit Symbol Substitution Test (DSST). We used a correlation analysis and multiple linear regression analysis to investigate whether higher CAVI was independently associated with lower executive function.

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Section: Discussionmentioning

confidence: 99%

Association between the Cardio-Ankle Vascular Index and Executive Function in Community-Dwelling Elderly People

Sugimoto

Misu

Sawa

et al. 2016

JAT

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“…WMH is associated with various geriatric conditions, 1 and regional WMH has specific effects on cognitive impairment, gait and lower urinary tract symptoms. [2][3][4] To measure WMH, visual rating and volumetric analysis using a computer program have been used. Volumetric measurement of WMH is more sensitive and accurate than visual rating, although the former requires specific laboratory instruments to analyze WMH.…”

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confidence: 99%

“…5 Automatic segmentation of WMH mostly recognized DWMH in continuity with PVH, and therefore the volume of DWMH is much smaller. 4 Thus, we hypothesized that semiquantitative analysis of PVH could predict total WMH volume. The purpose of the present study was to validate the accuracy of our newly developed visual rating scale for global and regional analysis of WMH.…”

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confidence: 99%

“…The protocol of brain MRI is described elsewhere. 4 WMH on brain MRI was evaluated by both visual and computational volumetric analysis. For visual rating, we used the Fazekas scale, 6 a scale used in the Rotterdam scan study (Rotterdam scale) 7 and our new scale, which is a modified version of the Rotterdam scale (modified Rotterdam scale).…”

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confidence: 99%

“…5 Recently, specific impacts of frontal WMH have been reported. 3,4 Not only the overall presence of WMH in the brain, but also the size and local distribution of WMH might directly cause several clinical symptoms. The modified Rotterdam scale showed the strongest association with frontal WMH/IC, which implies it is a more useful index than the other visual rating scales.…”

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confidence: 99%

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Validation of a simple and reliable visual rating scale of white matter hyperintensity comparable with computer‐based volumetric analysis

Ogama

Saji²,

Niida

et al. 2015

Geriatrics Gerontology Int

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White matter hyperintensity (WMH), which is detected as hyperintense signals on T2-weighted images of brain magnetic resonance imaging (MRI), is a common finding in the aging brain. WMH is associated with various geriatric conditions, 1 and regional WMH has specific effects on cognitive impairment, gait and lower urinary tract symptoms.2-4 To measure WMH, visual rating and volumetric analysis using a computer program have been used. Volumetric measurement of WMH is more sensitive and accurate than visual rating, although the former requires specific laboratory instruments to analyze WMH. Visual rating is timeconsuming, and the results often vary among raters. Because physicians have to evaluate longitudinal changes in WMH in patients during a limited consultation time, an easier and more reliable method of visual assessment is required. WMH can be divided into two parts; periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH). Previous studies suggested that PVH and DWMH largely share common pathological characteristics.5 Automatic segmentation of WMH mostly recognized DWMH in continuity with PVH, and therefore the volume of DWMH is much smaller.4 Thus, we hypothesized that semiquantitative analysis of PVH could predict total WMH volume. The purpose of the present study was to validate the accuracy of our newly developed visual rating scale for global and regional analysis of WMH. Comparison with conventional methods was carried out by referencing computational volumetric analysis.The participants were 460 patients (318 women) aged 65-85 years; 69 diagnosed with amnestic mild cognitive impairment and 391 with Alzheimer's disease. Clinical data were obtained from the Biobank of National Center for Geriatrics and Gerontology, which collects clinical data for research. All participants underwent brain MRI. The protocol of brain MRI is described elsewhere. 4 WMH on brain MRI was evaluated by both visual and computational volumetric analysis. For visual rating, we used the Fazekas scale, 6 a scale used in the Rotterdam scan study (Rotterdam scale) 7 and our new scale, which is a modified version of the Rotterdam scale (modified Rotterdam scale).2,3 The Fazekas scale is a simple classification of PVH (grade 0-3), whereas the Rotterdam scale and modified Rotterdam scale are semiquantitative methods. PVH in the Rotterdam scale is visually rated into four grades at frontal caps, bands and occipital caps. The total score was calculated by adding the three region-specific scores.7 In contrast, the modified Rotterdam scale rates PVH as five grades with definitive ranges of WMH dimension from the edge of ventricles at the identical regions of PVH, but separately in the left and right hemisphere. The degree of PVH was calculated by adding up the scores of six separate regions.

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Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study

Sleiman

Connolly

et al. 2023

Alzheimer's & Dementia

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BackgroundAs a collaboration model between the International HundredK+ Cohorts Consortium (IHCC) and the Davos Alzheimer's Collaborative (DAC), our aim was to develop a trans‐ethnic genomic informed risk assessment (GIRA) algorithm for Alzheimer's disease (AD).MethodsThe GIRA model was created to include polygenic risk score calculated from the AD genome‐wide association study loci, the apolipoprotein E haplotypes, and non‐genetic covariates including age, sex, and the first three principal components of population substructure.ResultsWe validated the performance of the GIRA model in different populations. The proteomic study in the participant sites identified proteins related to female infertility and autoimmune thyroiditis and associated with the risk scores of AD.ConclusionsAs the initial effort by the IHCC to leverage existing large‐scale datasets in a collaborative setting with DAC, we developed a trans‐ethnic GIRA for AD with the potential of identifying individuals at high risk of developing AD for future clinical applications.

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Frontal white matter hyperintensity predicts lower urinary tract dysfunction in older adults with amnestic mild cognitive impairment and Alzheimer's disease

Cited by 30 publications

References 21 publications

Association between the Cardio-Ankle Vascular Index and Executive Function in Community-Dwelling Elderly People

Association between the Cardio-Ankle Vascular Index and Executive Function in Community-Dwelling Elderly People

Validation of a simple and reliable visual rating scale of white matter hyperintensity comparable with computer‐based volumetric analysis

Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study

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