Frontal white matter alterations are associated with executive cognitive function in euthymic bipolar patients

Oertel-Knöchel, Viola; Reinke, Britta; Alves, Gilberto Sousa; Jurcoane, Alina; Wenzler, Sofia; Prvulovic, David; Linden, David; Knöchel, Christian

doi:10.1016/j.jad.2013.11.004

Cited by 72 publications

(45 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We analyzed DTI measures that are thought to reflect the following: 1) directional WM integrity (fractional anisotropy), 2) tissue breakdown with increased water content (mean diffusivity), and 3) the integrity of axons versus their adjacent myelin sheaths (radial diffusivity and axial diffusivity). 20 Diffusion anisotropy (fractional anisotropy) may not be enough to better characterize the tissue microstructure. If diffusion changes along the direction of the semi-major axis (axial diffusivity) are proportional to those of the semi-minor axes (radial diffusivity), then fractional anisotropy, which is the ratio of axial diffusivity and radial diffusivity, would remain relatively unchanged.…”

Section: Discussionmentioning

confidence: 99%

White Matter Correlates of Cognitive Impairment in Essential Tremor

Bhalsing¹,

Kumar

Saini

et al. 2014

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

White Matter Correlates of Cognitive Impairment in Essential Tremor

Bhalsing¹,

Kumar

Saini

et al. 2014

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…[29][30][31]40,[43][44][45][46]49 Regarding association tracts, five studies found decreased FA values in the cingulum. 29,43,45,48,49 With respect to the projection tracts, two studies noted decreased FA in the ATR, and one study found decreased FA in the corticospinal tract (CST) ( Table 2).…”

Section: Fa and Wm Tractsmentioning

confidence: 99%

“…The fornix is a projection tract that is located underneath the CC and connects the hippocampus with the mammillary body as well as with other cortical and subcortical structures. 30 Both structures are part of the limbic system and known to be involved in memory processes. The lack of previous reports regarding fornix alterations in BD may be due to the anatomic characteristics of the fornix and to the spatial resolution of current MRI methods.…”

Section: Continued On Next Pagementioning

confidence: 99%

“…[21][22][23][24][25] Other studies suggest that structural brain changes are found mainly in the frontal, temporal, and limbic white matter (WM) regions. [26][27][28][29][30][31] WM abnormalities have been widely detected in subjects with the pathophysiological features of BD, especially with diffusion tensor imaging (DTI) techniques. 29 Diffusion imaging principles are based on measurement of the motion of water molecules within tissues.…”

Section: Introductionmentioning

confidence: 99%

“…[35][36][37][38] Previous investigations have hypothesized that microstructural changes in the WM of frontal-subcortical circuits leads to a disconnection syndrome between the frontal and subcortical regions. 30 These network alterations have been associated with clinical symptoms of BD, which suggests that DTI is a promising technique for evaluation of the underpinnings of neuropathology in BD. 39 The aim of this paper is to conduct a systematic review of studies that have used DTI in patients with BD, with particular emphasis on fractional anisotropy (FA) findings, and discuss the relevance and connection of these findings to BD pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Duarte

Silva²,

Goldani³

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To review the available data on diffusion tensor imaging (DTI) of subjects with bipolar disorder (BD), with a particular focus on fractional anisotropy (FA) in white matter (WM) tracts. Methods: The PubMed/MEDLINE database was searched for relevant articles, which were included in a systematic review of the literature. FA reductions and WM abnormalities were divided anatomically into three groups: commissural tracts, association tracts, and projection tracts. Results: Eighteen studies met the inclusion criteria. The corpus callosum was the main impaired commissural tract as demonstrated by FA reductions. Five studies reported FA reductions in the cingulum. Two studies reported decreased FA in the anterior thalamic radiation, and one in the corticospinal tract. Conversely, three studies found increased FA values in WM tracts involved in BD pathophysiology. Conclusion: Despite considerable heterogeneity, these results indicate a direct link between executive cognitive functioning and abnormal WM microstructural integrity of fronto-limbic tracts in patients with remitted BD, providing further evidence of the neuronal disruption that underlies BD symptomatology.

show abstract

Unique white matter microstructural patterns in ADHD presentations—a diffusion tensor imaging study

Svátková

Nestrašil

Rudser

et al. 2016

Human Brain Mapping

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder predominantly inattentive (ADHD-PI) and combined (ADHD-C) presentations are likely distinct disorders that differ neuroanatomically, neurochemically, and neuropsychologically. However, to date, little is known about specific white matter (WM) regions differentiating ADHD presentations. This study examined differences in WM microstructure using diffusion tensor imaging (DTI) data from 20 ADHD-PI, 18 ADHD-C, and 27 typically developed children. Voxel-wise analysis of DTI measurements in major fiber bundles was carried out using tract-based spatial statistics (TBSS). Clusters showing diffusivity abnormalities were used as regions of interest for regression analysis between fractional anisotropy (FA) and neuropsychological outcomes. Compared to neurotypicals, ADHD-PI children showed higher FA in the anterior thalamic radiations (ATR), bilateral inferior longitudinal fasciculus (ILF) and in the left corticospinal tract (CST). In contrast, the ADHD-C group exhibited higher FA in the bilateral cingulum bundle (CB). In the ADHD-PI group, differences in FA in the left ILF and ATR were accompanied by axial diffusivity (AD) abnormalities. In addition, the ADHD-PI group exhibited atypical mean diffusivity in the forceps minor (FMi) and left ATR and AD differences in right CB compared to healthy subjects. Direct comparison between ADHD presentations demonstrated radial diffusivity differences in FMi. WM clusters with FA irregularities in ADHD were associated with neurobehavioral performance across groups. In conclusion, differences in white matter microstructure in ADHD presentations strengthen the theory that ADHD-PI and ADHD-C are two distinct disorders. Regions with white matter irregularity seen in both ADHD presentations might serve as predictors of executive and behavioral functioning across groups.

show abstract

Frontal white matter alterations are associated with executive cognitive function in euthymic bipolar patients

Cited by 72 publications

References 77 publications

White Matter Correlates of Cognitive Impairment in Essential Tremor

White Matter Correlates of Cognitive Impairment in Essential Tremor

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Unique white matter microstructural patterns in ADHD presentations—a diffusion tensor imaging study

Contact Info

Product

Resources

About