Frontal lobe dysfunction in patients with chronic migraine: a clinical–neuropsychological study

Mongini, Franco; Keller, Roberto; Deregibus, Andrea; Barbalonga, Erika; Mongini, Tullia

doi:10.1016/j.psychres.2003.12.028

Cited by 63 publications

(65 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study are consistent with those of a recent work [11], in which we administered the Object Alternation Test (OAT) to assess the function of the orbitofrontal cortex [12], in a group of women with chronic migraine. In the OAT the patient is asked to find a coin located under one of two identical boxes.…”

Section: Discussionsupporting

confidence: 89%

The Temperament and Character Inventory in women with migraine

et al. 2005

View full text Add to dashboard Cite

The purpose of this work was to investigate: (1) the differences in temperament and character between 49 women with migraine and 49 controls using the Temperament and Character Inventory (TCI), and (2) the extent to which these differences were related to migraine or to the presence of comorbid depression. The migraine patients scored significantly higher than the controls in two temperament dimensions—Harm Avoidance (HA) and Persistence (P)—and significantly lower in one character dimension—Self-Directedness (SDir) (Student’s t ). After multiple logistic regression, the TCI P and HA dimensions were significantly associated with the presence of migraine. The HA dimension was also related to the presence of depression. Our results show that in migraine the higher HA score could be partly associated to comorbid depression while the high P dimension seems to be solely related to the presence of migraine.

show abstract

Section: Discussionsupporting

confidence: 89%

The Temperament and Character Inventory in women with migraine

et al. 2005

View full text Add to dashboard Cite

show abstract

“…In a neuropsychological study aimed at assessing the function of the frontal lobe in female patients with chronic migraine, Mongini et al [11] found a change in the functioning of the prefrontal and orbitofrontal cortices, similar to those observed in psychiatric conditions (in particular, in obsessive-compulsive disorders), which seems to confirm, also from this perspective, the role of prefrontal and orbitofrontal cortices in head pain.…”

Section: Discussionmentioning

confidence: 58%

Cortical involvement during the description of head pain

et al. 2006

View full text Add to dashboard Cite

Pain perception involves several cortical areas. Our purpose was to examine cortical activity in patients describing their cephalic pain with the MacGill Pain Questionnaire (MPQ). Two SPECT analyses were performed in pain-free periods in 10 patients with migraine (n=8) or myogenous facial pain (n=2). The MPQ was administered in the first session, while no task was to be performed during the second session. Differences were calculated using statistical parametric mapping (SPM99), also taking the MPQ pain rating index (PRI) as covariance.During the MPQ session, clusters of activation were observed in the orbitofrontal cortex, the insula and the anterior cingulate cortex (ACC) of the left brain, but not significantly so. Using the MPQ PRI as covariate, significant areas of activation were found in the left frontal lobe, the Brodmann area 32 and in the ACC. The description of pain seems to activate cortical areas similar to those involved in actual pain perception.

show abstract

“…The partial benefit from detoxification and the severity bias led us to consider this subgroup of chronic-relapsing migraneurs as a separate phenotype, whose features might belong to the substance use disorders spectrum. Recent findings from neuroimaging and neuropsychological studies give strength to this hypothesis [6][7][8]30]. However, this study has a number of limitations.…”

Section: Discussionmentioning

confidence: 82%

“…The underlying neurobiology of MO is not well understood. Although it might come from coping with pain and disability associated with migraine, a persistent dysfunction of the orbitofrontal cortex (OFC) and the relative decision-making deficit have been recently reported [6][7][8]. These deficits might explain the above-mentioned maladaptive behaviors and place MO in the substance use disorders spectrum [6].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric screening for migraine patients

Gambini

Biagianti

Grazzi³

et al. 2013

Neurol Sci

View full text Add to dashboard Cite

Psychiatric disorders in migraine patients have a higher prevalence than general population. The presence of psychiatric comorbidities may influence the complexity of the migraine pictures and be related to medication overuse. Severely impaired chronic migraineurs presenting with medication overuse are a challenge for headache clinics. Psychiatric comorbities, such as dependency-like behaviors, anxiety and mood symptoms, might account for headacherelated disability and recurrent relapses into medication overuse after a successful detoxification. Within a sample of 63 chronic migraineurs with medication overuse and severe disability, we investigated to which extent clinical severity, affective states and attitudes about medication impact the overall functioning at time of detoxification. To unravel whether some of these factors could predict their long-term outcome, we followed and retest them 1 year after withdrawal. We hypothesized that the detoxification would have led to a partial improvement and not modified the attitudes toward medication and dependence. Detoxification improves most of the clinical and affective measures, but does not free from significant levels of pain intensity and headache-related disability. The partial benefit from detoxification, the severity bias and the maladaptive cognitive profile led us to believe that subgroups of chronic-relapsing migraineurs deserve a multidisciplinary approach that addresses not only the reduction of clinical severity but also specific cognitive and behavioral impairments.

show abstract

Frontal lobe dysfunction in patients with chronic migraine: a clinical–neuropsychological study

Cited by 63 publications

References 29 publications

The Temperament and Character Inventory in women with migraine

The Temperament and Character Inventory in women with migraine

Cortical involvement during the description of head pain

Psychiatric screening for migraine patients

Contact Info

Product

Resources

About