Frontal functions in depressed and nondepressed Parkinson's disease patients: Impact of severity stages

Silberman, Cláudia Débora; Laks, Jerson; Capitão, Cláudia; Rodrigues, Cláudia Soares; Moreira, Irene de Freitas Henriques; Vasconcellos, Luiz Felipe Rocha; Engelhardt, Eliasz

doi:10.1016/j.psychres.2006.04.020

Cited by 16 publications

(8 citation statements)

References 20 publications

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“…This speculation is also supported by an fMRI study that found brain activation in the middle frontal gyrus in healthy participants while performing the TMT [124]. In addition, the low scores on the letter fluency test found in depressed PD patients in the cognitive studies [31,33] could be explained by brain atrophy in the anterior cingulate gyrus [79,80]. The letter fluency task requires the participant to initiate extensive searches for suitable words.…”

Section: Discussionmentioning

confidence: 88%

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Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review

Alzahrani

Venneri

2015

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 88%

“…There are, however, a few other studies that did not detect a significant association between depression and variance in cognitive deficit in PD (See table 1) [31][32][33][34]. In this disease, cognitive deficits may occur as a form of global cognitive decline or as an impairment of specific cognitive domains.…”

Section: Depressionmentioning

confidence: 99%

Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review

Alzahrani

Venneri

2015

Journal of the Neurological Sciences

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“…For each part, time, and number of errors are considered in the score. A ratio index (C/D) of interference was used 27,28…”

Section: Methodsmentioning

confidence: 99%

Acute exercise improves cognition in the depressed elderly: the effect of dual-tasks

Vasques

Moraes

Silveira

et al. 2011

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OBJECTIVE:The goal of this study was to assess the acute effect of physical exercise on the cognitive function of depressed elderly patients in a dual-task experiment.INTRODUCTION:Physical exercise has a positive effect on the brain and may even act as a treatment for major depressive disorder. However, the effects of acute cardiovascular exercise on cognitive function during and after one session of aerobic training in elderly depressive patients are not known.METHODS:Ten elderly subjects diagnosed with major depressive disorder performed neuropsychological tests during and after a moderate physical exercise session (65-75%HRmax). A Digit Span Test (Forward and Backward) and a Stroop Color-Word Test were used to assess cognitive function. The elderly participants walked on an electric treadmill for 30 minutes and underwent the same cognitive testing before, during, immediately after, and 15 minutes after the exercise session. In the control session, the same cognitive testing was conducted, but without exercise training.RESULTS:The results of the Digit Span Test did not change between the control and the exercise sessions. The results of the Stroop Color-Word Test improved after physical exercise, indicating a positive effect of exercise on cognition.CONCLUSIONS:These data suggest that the cognitive functions of depressed elderly persons, especially attention and inhibitory control, are not impaired during and after an acute session of physical exercise. In contrast, the effect of dual-tasks showed beneficial results for these subjects, mainly after exercise. The dual-task may be a safe and useful tool for assessing cognitive function.

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“…Some studies have failed to see any association between psychiatric symptoms and cognitive performance . The mixed findings may also be due to the variable degree of cognitive impairment in the study population observed where by the link between psychiatric symptoms and cognitive performance may be stronger in individuals experiencing cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease

Petkus

Filoteo

Schiehser

et al. 2020

Int J Geriat Psychiatry

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Objective Mild cognitive impairment (MCI) and psychiatric symptoms (anxiety, depression, and apathy) are common in Parkinson's disease (PD). While studies have supported the association between psychiatric symptoms and cognitive performance in PD, it is unclear if the magnitude of link between psychiatric symptoms and cognitive health is stronger by MCI status. The purpose of this study was to examine the association between cognitive performance and psychiatric symptoms in PD and whether MCI status moderates this association. Methods/Design Participants (N = 187) completed a comprehensive neuropsychological assessment that included measures of attention, language, executive function (EF), visuospatial ability, episodic memory, and psychiatric symptoms. Participants were classified as PD‐MCI (N = 73) or PD‐normal cognition (NC; N = 114). Linear regression analyses were conducted to examine the association between psychiatric symptoms and cognitive performance and the moderating effect of PD‐MCI status. Results There were no differences in mean psychiatric symptoms between PD‐MCI and PD‐NC. Psychiatric symptoms were predominantly associated with worse EF. The magnitude of the association between anxiety and worse EF was larger in participants with PD‐MCI compared with PD‐NC. A multivariable regression analysis examining the independent contributions of each symptom demonstrated the most robust association between EF and anxiety. Conclusions Symptoms of anxiety, depression, and apathy are associated with worse executive functioning in individuals with PD. PD‐MCI may be important in moderating the association between cognitive performance, specifically anxiety, and EF. Factors that promote cognitive resilience may serve as key therapeutic modalities in managing neuropsychiatric symptoms in PD.

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Frontal functions in depressed and nondepressed Parkinson's disease patients: Impact of severity stages

Cited by 16 publications

References 20 publications

Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review

Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review

Acute exercise improves cognition in the depressed elderly: the effect of dual-tasks

Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease

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