Frontal fibrosing alopecia treatment with Nd:YAG (1064 nm) nonablative laser

Subash, Jacob; Eginli, Ariana; Bomar, Leonora; McMichael, Amy J.

doi:10.1016/j.ijwd.2020.10.007

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Additionally, perifollicular hyperkeratosis and erythema was reduced, and hair loss was stabilized. No significant adverse effects were noted in patients [57].…”

Section: Minoxidilmentioning

confidence: 82%

The Frontal Fibrosing Alopecia Treatment Dilemma

Krzesłowska,

Woźniacka

2024

JCM

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Frontal fibrosing alopecia (FFA) is a type of cicatricial alopecia predominantly observed in postmenopausal women, with the incidence rising since its initial description in 1994. The exact etiopathogenesis of the disease has not been completely elucidated. FFA is characterized by an inflammatory process affecting the hair follicles of the fronto-temporal hairline, leading to its gradual recession. Eyebrows, particularly the lateral parts, may also be affected. Early diagnosis and an implementation of effective therapy to limit the inflammatory process are crucial in halting disease progression. Various treatment possibilities have been reported, including anti-inflammatory and immunosuppressive agents, as well as 5-alpha-reductase inhibitors, retinoids, and antimalarial agents. The use of phototherapy and surgical procedures has also been described. However, most available data have been obtained retrospectively, frequently consisting of descriptions of case reports or small case series, and not from randomized controlled trials. In addition, the etiopathogenesis of FFA remains unclear and its course unpredictable, occasionally being linked with spontaneous stabilization. Hence, no precise guidelines exist regarding treatment modalities. Therefore, the aims of this study were to provide a comprehensive review of the efficacy of existing therapeutic modalities for FFA and to highlight novel therapeutic options.

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“…Additionally, perifollicular hyperkeratosis and erythema was reduced, and hair loss was stabilized. No significant adverse effects were noted in patients [57].…”

Section: Minoxidilmentioning

confidence: 82%

The Frontal Fibrosing Alopecia Treatment Dilemma

Krzesłowska,

Woźniacka

2024

JCM

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“…A study about Nd:YAG (1064) non-ablative laser, carried out on 5 FFA patients, found improvement in symptoms and in perifollicular hyperkeratosis and follicular erythema in some patients [46]. Moreover, facial papules, lichen planus pigmentosus and hair loss spreading, also improved in some patients.…”

Section: Treatments Based On Light Devicesmentioning

confidence: 99%

Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris

Porriño‐Bustamante¹,

Fernández‐Pugnaire²

2023

Alopecia Management - An Update

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The aim of the treatment in frontal fibrosing alopecia and lichen planopilaris is to alleviate symptoms and to arrest the progression of the hair loss, since hair regrowth is not possible once the destruction of hair follicle has happened. Topical corticosteroids and tacrolimus are used to reduce inflammation, but with no clear benefit in slowing the alopecia. Intralesional corticosteroids may obtain hair regrowth in some patients, and they are especially useful in the treatment of eyebrow alopecia in frontal fibrosing alopecia. Regarding systemic treatments, the use of 5-alpha reductase inhibitors has been shown to be the most effective one to get stabilization in frontal fibrosing alopecia and even regrowth in the hairline. Hydroxychloroquine and oral immunomodulators are especially helpful as oral treatment in lichen planopilaris. Low-dose oral isotretinoin is the preferred treatment for facial papules in frontal fibrosing alopecia. The combination of oral and topical treatments is the best therapeutic choice.

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“…Also, using the Nd:YAG nonablative laser was reported as an efective method to improve disease symptoms [54].…”

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confidence: 99%

Treatment of Frontal Fibrosing Alopecia

Beyzaee

Goldust

Patil

et al. 2023

Dermatologic Therapy

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Introduction. Frontal fibrosing alopecia (FFA) is known as a lymphocytic primary cicatricial alopecia. The main characteristic of FFA is progressive frontotemporal hairline recession. The pathogenesis of FFA is not completely understood. Destructing the stem cells of the epithelial hair follicles causes permanent hair loss and seems to be the main cause of FFA. Studies have reported significantly decreased quality of life in patients with hair loss. On the other hand, late diagnosis and treatment of FFA can decrease the success rate of the treatment. In this regard, different topical and systemic therapies have been developed to resolve the symptoms; however, only a partial response to treatment is usually achieved. We conducted a systematic review of the literature to identify the effectiveness of the available treatment modalities used for FFA patients and the related outcomes. Methods. On April 2022, we made a wide systematic computer-assisted search of PubMed and Google Scholar databases, using “frontal fibrosing alopecia” and “treatment” keywords. We scanned 1,514 articles. All the studies concerning a therapeutic regimen for FFA were included. After removing duplicate studies, 50 studies containing the therapeutic regimen of 1,478 FFA patients were included in this review. Results. The 5-alpha-reductase inhibitors (oral finasteride/dutasteride) were the most used medications (usually prescribed as a combination therapy with other medications). Topical corticosteroids were the second commonly used medication for the treatment of FFA. Systemic corticosteroids seem to be ineffective in improving FFA progression. Oral isotretinoin (or alitretinoin) had the most promising effect on improving facial papules of FFA patients with a 92% rate of facial papule improvement. Conclusion. In our review, intralesional corticosteroid injection and 5-alpha-reductase inhibitors (finasteride/dutasteride) were reported as the most effective treatment modalities. Oral isotretinoin (or alitretinoin) is considered as the most promising treatment for improving facial papules in the context of FFA. However, it had minimal effects on hair regrowth or stabilization of hairline recession in FFA patients.

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Frontal fibrosing alopecia treatment with Nd:YAG (1064 nm) nonablative laser

Cited by 4 publications

References 3 publications

The Frontal Fibrosing Alopecia Treatment Dilemma

The Frontal Fibrosing Alopecia Treatment Dilemma

Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris

Treatment of Frontal Fibrosing Alopecia

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Frontal fibrosing alopecia treatment with Nd:YAG (1064 nm) nonablative laser

Cited by 4 publications

References 3 publications

The Frontal Fibrosing Alopecia Treatment Dilemma

The Frontal Fibrosing Alopecia Treatment Dilemma

Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris

Treatment of Frontal Fibrosing Alopecia

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Product

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Frontal fibrosing alopecia treatment with Nd:YAG (1064 nm) nonablative laser