Frontal fibrosing alopecia: is the melanocyte of the upper hair follicle the antigenic target?

Katoulis, Alexander; Diamanti, Konstantina; Sgouros, Dimitrios; Liakou, Aikaterini I.; Bozi, Evaggelia; Tzima, Korina; Panayiotides, Ioannis G.; Rigopoulos, Dimitrios

doi:10.1111/ijd.14021

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…A decrease to the absence of labelling with Ki-67, a proliferative marker, and a downregulation of the hair follicle epithelial progenitor cell marker keratin 15, within the bulge area, have already been described in LPP [ 27 , 28 ]. The melanocyte of the hair follicle might be an antigenic target in FFA [ 29 ]; this is supported by the lower melanocyte count found in the upper follicle in lesional skin from FFA patients (not seen in LPP) [ 26 , 30 ].…”

Section: Aetiopathogenesismentioning

confidence: 99%

Frontal Fibrosing Alopecia: A Review

Porriño‐Bustamante

Fernández‐Pugnaire

Arias‐Santiago

2021

JCM

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Frontal fibrosing alopecia is a scarring alopecia, the prevalence of which is increasing worldwide since its first description in 1994. The reason for this emerging epidemic may be a higher exposure to an unknown trigger, although its aethiology and pathogenesis still remain enigmatic. Clinical, trichoscopic, sonographic, and histopathologic findings are allowing clinicians to understand more aspects about this type of cicatricial alopecia. Several treatments have been used in frontal fibrosing alopecia, although the 5-alpha reductase inhibitors seem to be the most promising. The aim of this report is to provide a compilation about the published data regarding frontal fibrosing alopecia in a narrative review.

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Section: Aetiopathogenesismentioning

confidence: 99%

Frontal Fibrosing Alopecia: A Review

Porriño‐Bustamante

Fernández‐Pugnaire

Arias‐Santiago

2021

JCM

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“…In FFA, similar to LPP, there is an infiltration of CD8+ T lymphocytes and the loss of immune privilege in the hair follicle due to the action of interferon-gamma. However, in addition to these factors, genetic factors, hormones, altered neuropeptide expression, antigenic role of melanocytes, and environmental factors have been implicated in the pathogenesis of this disease [3, 4, 17].…”

Section: Discussionmentioning

confidence: 99%

JAK Inhibitors in the Treatment of Lichen Planopilaris

Nasimi,

Ansari

2023

Skin Appendage Disord

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Background: Lichen planopilaris (LPP) is an autoimmune disorder leading to lymphocytic cicatricial alopecia. Different agents such as hydroxychloroquine, methotrexate, cyclosporine, and mycophenolate mofetil have been tried to control hair loss with limited efficacy. JAK inhibitors are immune-modulating drugs which interfere with the JAK-STAT signaling pathway in lymphocytes and are used in treatment of inflammatory conditions such as rheumatoid arthritis and alopecia areata. Summary: Our aim was to determine effectiveness of JAK inhibitors in LPP and its clinical variant, frontal fibrosing alopecia. A literature search was conducted using PubMed, Google Scholar, and Cochrane databases. A total of 7 articles describing 35 patients were found. Although data on treatment are limited to retrospective studies and case reports, JAK inhibitors can be considered a new therapeutic option, especially in recalcitrant cases. Large prospective studies and randomized control trials are needed to provide further evidence supporting efficacy. Key Messages: Besides the fact that data on the treatment of LPP and FFA with JAK inhibitors are limited to retrospective studies and case reports, but JAK inhibitors can be considered as a new therapeutic option especially in recalcitrant cases.

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“…Hypothyroidism was present in up to 30% of FFA cases in several studies, suggesting an autoimmune mechanism in the pathogenesis of the disease. According to Katoulis et al, the melanocyte of the hair follicle might be an antigenic target in FFA [9]. Histological analysis showed lower melanocyte counts in FFA patients were associated with clinical observations of skin hypopigmentation [10].…”

Section: Etiopathogenesismentioning

confidence: 99%

Frontal fibrosing alopecia: a disease that remains enigmatic

Lis‐Święty

Brzeźińska-Wcisło

2020

pdia

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Frontal fibrosing alopecia (FFA) is recognized to represent a generalized process of inflammatory scarring alopecia. Apart from the classic form affecting the frontal hairline, there are a range of disease manifestations involving loss of eyebrows and of eyelashes, loss of peripheral body hair, fibrosing alopecia in a pattern distribution, facial and extrafacial skin, mucous membrane, and nail involvement. Classic linear, diffuse "zigzag", pseudo "fringe sign", androgenetic alopecia-like, cockade-like, ophiasis-like and incomplete patterns are distinguished. The aetiology of FFA remains obscure, but a number of pathogenetic hypotheses and treatments to halt disease progression have been proposed.

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Frontal fibrosing alopecia: is the melanocyte of the upper hair follicle the antigenic target?

Cited by 8 publications

References 6 publications

Frontal Fibrosing Alopecia: A Review

Frontal Fibrosing Alopecia: A Review

JAK Inhibitors in the Treatment of Lichen Planopilaris

Frontal fibrosing alopecia: a disease that remains enigmatic

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