Frontal fibrosing alopecia associated with lichen planus pigmentosus: A multicentre retrospective descriptive analytical study of 104 patients

Brito, Flavia Oliveira Xavier de; Almeida, Rita Fernanda Cortez de; Machado, Carla Jorge; Lemes, Luciana Rodino; Donda, André Luiz Vairo; Blanco, Aline; Silveira, Aline Lucy Galavotti; Munck, Andreia; Lima, Caren dos Santos; Canela, Carolina Porto Cotrim; Fechine, Carolina Oliveira Costa; Obadia, Daniel Lago; Pinto, Giselle Martins; Alves, Lorena Dourado; Dias, Maria Fernanda Reis Gavazzoni; Benez, Marcela; Rigatti, Marcelo; Paiva, Nadia Tavares El Kadi Monteiro; Kakizaki, Priscila; Minotto, Renan; Frattini, Sidney; Ramos, Paulo Müller; Melo, Daniel Fernandes

doi:10.1111/jdv.19093

Cited by 3 publications

(10 citation statements)

References 7 publications

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“…It was first described in 2013 by Dlova et al in 24 patients in South Africa [10]. Since then, many articles have identified this association in English literature [7,[11][12][13][14][15][16][17][18]. The largest study was a multi-centric retrospective study of 104 patients.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the mean age was 60.5 years, and 97.1% of the patients were females. Most patients were postmenopausal, corresponding to the general FFA epidemiology [11]. The association of FFA with LPPigm was noticed to be more common in women of dark skin phototypes (IV-VI), in which LPPigm is more prevalent [7,[10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Most patients were postmenopausal, corresponding to the general FFA epidemiology [11]. The association of FFA with LPPigm was noticed to be more common in women of dark skin phototypes (IV-VI), in which LPPigm is more prevalent [7,[10][11][12]. However, few articles reported this association in Caucasians or lighter skin phototypes (II and III).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Coexistence of Lichen Planus Pigmentosus and Classic Lichen Planopilaris: A Case Report and Literature Review

Almarek,

AlQadri,

Alotaibi

2023

Cureus

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Coexistence of Lichen Planus Pigmentosus and Classic Lichen Planopilaris: A Case Report and Literature Review

Almarek,

AlQadri,

Alotaibi

2023

Cureus

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“…1 It mainly occurs in post-menopausal women and has a negative impact on the quality of patients' life, and even might inducing psychological distress. 2,3 Some risk factors were found in recent studies, including sunscreen usage, tobacco consumption, thyroid disorders, and rosacea. [4][5][6] More and more studies have showed increasing interests in cicatricial alopecia.…”

Section: Introductionmentioning

confidence: 99%

“…Frontal fibrosis alopecia (FFA) is a type of primary lymphocytic cicatricial alopecia, characterized by the progressive hair loss of eyebrow and frontotemporal 1 . It mainly occurs in post‐menopausal women and has a negative impact on the quality of patients’ life, and even might inducing psychological distress 2,3 . Some risk factors were found in recent studies, including sunscreen usage, tobacco consumption, thyroid disorders, and rosacea 4–6 …”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis of frontal fibrosis alopecia revealed involvement of immune cells and ferroptosis

Liu,

Xue,

Wang

et al. 2024

Skin Research and Technology

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BackgroundFrontal fibrosis alopecia (FFA) is a primary cicatricial alopecia and has received increasing attention in recent years. However, the pathogenesis of FFA has not been fully elucidated.Methods and resultsHerein, we collected the transcriptome data of scalp lesions of seven patients with FFA and seven healthy controls. The differential expression analysis and weighted gene co‐expression network analysis were conducted and we identified 458 differentially expressed genes (DEGs) in two key modules. Later, we performed functional enrichment analysis and functional modules identification, revealing the participation of immune response and fatty acid metabolism. Based on the results, we processed further studies. On the one hand, we analyzed the infiltrating immune cells of FFA through CIBERSORT algorithm, indicating the activation of M1 macrophage and CD8+ T cell. On the other hand, considering lipid metabolism of FFA and oxidative stress of hair follicle cells in alopecia, we explored the potential ferroptosis of FFA. By intersection of DEGs and ferroptosis‐related genes from FerrDb database, 19 genes were identified and their expression was validated in an external dataset containing 36 FFA cases and 12 controls. Then, we used LASSO algorithms to construct a four‐gene diagnostic model, which achieved an AUC of 0.924 in validation dataset. Additionally, the immune cells were found to be related to ferroptosis in FFA.ConclusionTaken together, this study contributed to reveal the molecular mechanisms of FFA and is expected to inspire future research on treatment.

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Trichoscopy of Frontal Fibrosing Alopecia Affecting Black Scalp: A Literature Review

Souza,

Cortez de Almeida,

Melo

2024

Skin Appendage Disord

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Background: Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia characterized by progressive recession of the frontotemporal hairline, affecting mainly postmenopausal and, lately, premenopausal women of African descent. Considering the importance of trichoscopy on FFA diagnosis and the peculiarities found in patients with higher skin phototypes, this study aimed to review the FFA trichoscopy in the black scalp (Fitzpatrick IV–VI), a topic that remains sparsely described in the existing literature. Summary: In black patients, FFA may manifest singular features on presentation posing diagnostic clinical and trichoscopic challenges. This group has lower prevalence of the FFA compared to other alopecias. It may have an earlier age of onset and often exhibits more severe manifestations due to the coexistence of other types of alopecia and delay in diagnosis. The early signs of the disease in black patients may manifest in the eyebrows before scalp hair loss and lichen planus pigmentosus may be a herald sign. Key Messages: Our research analyzes FFA trichoscopy findings in black patients to help precise diagnosis and treatment. Raising awareness of the disease characteristics on trichoscopy contributes to improving hair care in this population.

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Frontal fibrosing alopecia associated with lichen planus pigmentosus: A multicentre retrospective descriptive analytical study of 104 patients

Cited by 3 publications

References 7 publications

Coexistence of Lichen Planus Pigmentosus and Classic Lichen Planopilaris: A Case Report and Literature Review

Coexistence of Lichen Planus Pigmentosus and Classic Lichen Planopilaris: A Case Report and Literature Review

Transcriptome analysis of frontal fibrosis alopecia revealed involvement of immune cells and ferroptosis

Trichoscopy of Frontal Fibrosing Alopecia Affecting Black Scalp: A Literature Review

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