Frontal fibrosing alopecia and lichen planus pigmentosus: is there a link?

Dlova, Ncoza C.

doi:10.1111/j.1365-2133.2012.11146.x

Cited by 90 publications

(130 citation statements)

References 11 publications

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“…However, as we recall FFA's epidermal involvement [6,7,8] with clear predilection for sun-exposed areas associated to DIF findings, FFA would be better placed in the middle of a spectrum of primary cicatricial alopecias between LPP and LE and thus considered a stand-alone form of primary cicatricial alopecia.…”

Section: Discussionmentioning

confidence: 99%

The Use of Direct Immunofluorescence in Frontal Fibrosing Alopecia

Donati

Gupta

Jacob

et al. 2017

Skin Appendage Disord

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Background: Frontal fibrosing alopecia (FFA) differs from lichen planopilaris (LPP) in many clinical aspects, but histology fails to distinguish between these entities. Direct immunofluorescence (DIF) is a diagnostic technique used for autoimmune diseases, including those affecting skin and hair. Objective: To characterize DIF patterns in patients with FFA. Method: Data was collected retrospectively from FFA cases presenting to the Centre de Santé Sabouraud Hair Clinic in Paris from November 2013 to November 2014. Results: Of 149 patients with FFA, 44 cases underwent DIF. Thirteen cases showed positive results with DIF. Patterns characteristic of LPP and lupus erythematosus were observed, with nearly half showing nonspecific staining. Conclusion: DIF patterns in patients with FFA were variable. This diagnostic technique should be used with caution in cases of cicatricial alopecia, particularly FFA.

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Section: Discussionmentioning

confidence: 99%

The Use of Direct Immunofluorescence in Frontal Fibrosing Alopecia

Donati

Gupta

Jacob

et al. 2017

Skin Appendage Disord

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“…Frequent skin involvement in FFA was first acknowledged in 2012 when more than 50% of African FFA patients were shown to have hyperchromic macules on sunexposed areas and Lichen Planus (LP) pigmentosus was confirmed histologically showing lichenoid epidermal changes [1]. Here we present a Caucasian FFA patient who developed achromic macules over the front and neck, whose biopsy showed epidermal interface changes similar to LP pigmentosus.…”

Section: Introductionmentioning

confidence: 93%

“…Frontal Fibrosing Alopecia (FFA) is a primary cicatricial alopecia that presents with typical band-like frontal alopecia, usually in postmenopausal women [1,2]. Frequent skin involvement in FFA was first acknowledged in 2012 when more than 50% of African FFA patients were shown to have hyperchromic macules on sunexposed areas and Lichen Planus (LP) pigmentosus was confirmed histologically showing lichenoid epidermal changes [1].…”

Section: Introductionmentioning

confidence: 99%

Vitiligo-Like Patches due to Epidermal Interface Changes in Frontal Fibrosing Alopecia: Further Evidence of Non-Follicular Involvement

R¹

2015

Pigmentary Disorders

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“…In all cases, the cutaneous involvement preceded the alopecia by 6-36 months [5]. Since 2012, only 2 further reports of FFA-associated LP pigmentosus have been published in the English literature [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Lichen planus (LP) pigmentosus is a rare variant of LP presenting clinically as a diffuse, reticulated, blotchy, linear or perifollicular slate gray to brownish-black pigmentation on sun-exposed areas, mainly the face and the neck [5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Clinical and Histopathological Findings of Frontal Fibrosing Alopecia-Associated Lichen Planus Pigmentosus

Romiti

Gavioli

Anzai

et al. 2017

Skin Appendage Disord

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Background: Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia occurring mainly in postmenopausal women. A range of facial lesions have been described in FFA, such as lichen planus (LP) pigmentosus, red dots, facial papules, and perifollicular and diffuse erythema. These lesions can be the first sign of FFA. LP pigmentosus is a rare variant of LP. The first description of LP pigmentosus associated with FFA (in 2012) reported 22 cases of LP pigmentosus among 44 cases of FFA affecting South African patients. Methods: We reviewed 16 FFA patients with LP pigmentosus and the histopathological findings of the biopsy of LP pigmentosus in 9 patients. Results: Most patients had intermediate skin phototypes (III-IV; n = 10; 62%). The age at onset of LP pigmentosus ranged from 30 to 60 years. The most common histopathological findings were epidermal atrophy, basal cell degeneration, interfollicular inflammatory infiltrate and melanophages, and perifollicular changes. Other findings not previously described in LP pigmentosus were inflammation and interface changes on sweat duct epithelia (acrosyringium and superior dermal duct), and lichenoid perisebaceitis. Conclusions: Histology of our cases confirmed previous findings and showed a high incidence of perifollicular involvement with occasional changes affecting sebaceous and sweat glands.

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Frontal fibrosing alopecia and lichen planus pigmentosus: is there a link?

Cited by 90 publications

References 11 publications

The Use of Direct Immunofluorescence in Frontal Fibrosing Alopecia

The Use of Direct Immunofluorescence in Frontal Fibrosing Alopecia

Vitiligo-Like Patches due to Epidermal Interface Changes in Frontal Fibrosing Alopecia: Further Evidence of Non-Follicular Involvement

Clinical and Histopathological Findings of Frontal Fibrosing Alopecia-Associated Lichen Planus Pigmentosus

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