Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study

Ookawa, Satoshi; Enatsu, Rei; Kanno, Aya; Ochi, Satoko; Akiyama, Yukinori; Tamaki, Kunihiko; Yamao, Yukihiro; Kikuchi, Takayuki; Matsumoto, Riki; Kunieda, Takeharu; Mikuni, Nobuhiro

doi:10.1016/j.wneu.2017.07.166

Cited by 37 publications

(24 citation statements)

References 12 publications

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“…Future research comparing results across target and nontarget contacts is needed to infer which components of the evoked potential, if any, are therapeutically relevant. In the meantime, our descriptive evidence that the p40 feature may reflect forceps minor activation is consistent with empirical findings that link the stimulation evoked response (e.g., CCEP) to white matter activation (e.g., Conner et al, 2011; Keller et al, 2018; Ookawa et al, 2017, Yamao et al, 2017). Making this leap in the context of SCC-DBS may require more precise biophysical modeling of neural elements, further exploitation of invasive recording in the OR and utilization of animal models.…”

Section: Discussionsupporting

confidence: 90%

“…Both CCEP and TEP have been explored as a measure of effective connectivity, which refers to the causal influence between cortical regions and the propagation of electrical signal across large-scale brain networks (Entz et al, 2014; Keller et al, 2011, 2014; Massimini et al, 2005; Matsumoto et al, 2006; Miniussi & Thut, 2010). Importantly, a growing literature also links CCEP and TEP features to white matter integrity and structural connectivity (Conner et al, 2011; Keller et al, 2018; Ookawa et al, 2017; Yamao et al, 2017). …”

Section: Introductionmentioning

confidence: 99%

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Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Waters

Veerakumar²,

Choi

et al. 2018

Human Brain Mapping

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Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers is now central to the model of SCC DBS treatment efficacy. A method to confirm SCC DBS target engagement is needed to reduce procedural variance across treatment providers and to optimize DBS parameters for individual patients. We examined the reliability of a novel cortical evoked response that is time-locked to a 2 Hz DBS pulse and shows the propagation of signal from the DBS target. The evoked response was detected in four individuals as a stereotyped series of components within 150 ms of a 6 V DBS pulse, each showing coherent topography on the head surface. Test-retest reliability across four repeated measures over 14 months met or exceeded standards for valid test construction in three of four patients. Several observations in this pilot sample demonstrate the prospective utility of this method to confirm surgical target engagement and instruct parameter selection. The topography of an orbital frontal component on the head surface showed specificity for patterns of forceps minor activation, which may provide a means to confirm DBS location with respect to key white matter structures. A divergent cortical response to unilateral stimulation of left (vs. right) hemisphere underscores the need for feedback acuity on the level of a single electrode, despite bilateral presentation of therapeutic stimulation. Results demonstrate viability of this method to explore patient-specific cortical responsivity to DBS for brain-circuit pathologies.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Waters

Veerakumar²,

Choi

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

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“…Finally, a small number of studies have provided electrophysiological evidence of a monosynaptic connection between IFG and medial superior frontal gyrus (Enatsu et al, 2016;Matsumoto et al, 2007;Ookawa et al, 2017;Swann et al, 2012). Enatsu and colleagues (2016) investigated 18 patients using cortico-cortical evoked potentials (CCEP) and found that stimulation of the pre-SMA induces a robust response in IFG.…”

Section: Anatomy and Connectivity Of The Frontal Aslant Tractmentioning

confidence: 99%

The frontal aslant tract (FAT) and its role in speech, language and executive function

Dick

Garic

Graziano

et al. 2019

Cortex

199

125

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In this review, we examine the structural connectivity of a recently-identified fiber pathway, the frontal aslant tract (FAT), and explore its function. We first review structural connectivity studies using tract-tracing methods in non-human primates, and diffusion-weighted imaging and electrostimulation in humans. These studies suggest a monosynaptic connection exists between the lateral inferior frontal gyrus and the pre-supplementary and supplementary motor areas of the medial superior frontal gyrus. This connection is termed the FAT. We then review research on the left FAT's putative role in supporting speech and language function, with particular focus on speech initiation, stuttering and verbal fluency. Next, we review research on the right FAT's putative role supporting executive function, namely inhibitory control and conflict monitoring for action. We summarize the extant body of empirical work by suggesting that the FAT plays a domain general role in the planning, timing, and coordination of sequential motor movements through the resolution of competition among potential motor plans. However, we also propose some domain specialization across the hemispheres. On the left hemisphere, the circuit is proposed to be specialized for speech actions. On the right hemisphere, the circuit is proposed to be specialized for general action control of the organism, especially in the visuo-spatial domain. We close the review with a discussion of the clinical significance of the FAT, and suggestions for further research on the pathway.

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“…BA6 is a pre-motor area connected to Broca's area (92), anteriorly adjacent BA8 is involved in the management of uncertainty (96), and BA9 is involved in a number of complex language processes (92), while BA10 is implicated in memory recall and executive functions, as well as in language processing that lacks automaticity (97). In the left hemisphere, a connection exists between the Broca region and the SFG (98), and lesions to the left lateral prefrontal cortex impaired decision threshold adjustment for lexical selection (99). In combination with the left IFG, SFG has been shown to be involved in word selection (100) and with conceptually driven word retrieval (101).…”

Section: Extended Spatial Activation With Bimodal Hearingmentioning

confidence: 99%

Changes in Speech-Related Brain Activity During Adaptation to Electro-Acoustic Hearing

et al. 2020

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Objectives: Hearing improves significantly with bimodal provision, i.e., a cochlear implant (CI) at one ear and a hearing aid (HA) at the other, but performance shows a high degree of variability resulting in substantial uncertainty about the performance that can be expected by the individual CI user. The objective of this study was to explore how auditory event-related potentials (AERPs) of bimodal listeners in response to spoken words approximate the electrophysiological response of normal hearing (NH) listeners. Study Design: Explorative prospective analysis during the first 6 months of bimodal listening using a within-subject repeated measures design. Setting: Academic tertiary care center. Participants: Twenty-seven adult participants with bilateral sensorineural hearing loss who received a HiRes 90K CI and continued use of a HA at the non-implanted ear. Age-matched NH listeners served as controls. Intervention: Cochlear implantation. Main Outcome Measures: Obligatory auditory evoked potentials N1 and P2, and the event-related N2 potential in response to monosyllabic words and their reversed sound traces before, as well as 3 and 6 months post-implantation. The task required word/nonword classification. Stimuli were presented within speech-modulated noise. Loudness of word/non-word signals was adjusted individually to achieve the same intelligibility across groups and assessments. Results: Intelligibility improved significantly with bimodal hearing, and the N1-P2 response approximated the morphology seen in NH with enhanced and earlier responses to the words compared to their reversals. For bimodal listeners, a prominent negative deflection was present between 370 and 570 ms post stimulus onset (N2), irrespective of stimulus type. This was absent for NH controls; hence, this response did not approximate the NH response during the study interval. N2 source localization evidenced extended activation of general cognitive areas in frontal and prefrontal brain areas in the CI group. Balkenhol et al. Adaptation to Electro-Acoustic Hearing Conclusions: Prolonged and spatially extended processing in bimodal CI users suggests employment of additional auditory-cognitive mechanisms during speech processing. This does not reduce within 6 months of bimodal experience and may be a correlate of the enhanced listening effort described by CI listeners.

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Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study

Cited by 37 publications

References 12 publications

Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Test–retest reliability of a stimulation‐locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

The frontal aslant tract (FAT) and its role in speech, language and executive function

Changes in Speech-Related Brain Activity During Adaptation to Electro-Acoustic Hearing

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