Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline

Morimoto, Nobutoshi; Kurata, Tomoko; Sato, Kota; Ikeda, Yoshio; Sato, Shuhei

doi:10.1016/j.jns.2012.04.020

Cited by 13 publications

(18 citation statements)

References 31 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We and other groups have reported the validity of computerized touch-panel screening tests as tools for detecting AD (3)(4)(5), ischemic stroke (6), Parkinson's disease (7) and amyotrophic lateral sclerosis (8). However, touch-panel tests have not been previously used to examine and detect patients with MCI.…”

Section: Introductionmentioning

confidence: 99%

Computerized Touch-panel Screening Tests for Detecting Mild Cognitive Impairment and Alzheimer's Disease

et al. 2015

Self Cite

View full text Add to dashboard Cite

Objective The increasing population of elderly people in Japan has accelerated the demand for a simple screening test to detect cognitive and affective declines in mild cognitive impairment (MCI) and the early stage of dementia. Methods We compared the cognitive and affective functions, activities of daily living (ADLs) and the results of four computerized touch-panel screening tests in 41 MCI subjects, 124 patients with Alzheimer's disease (AD) and 75 age-and gender-matched normal controls. Results All computerized touch-panel games were successfully used to discriminate the AD patients from the normal controls (** p<0.01). Although there were no differences in the findings of the conventional cognitive assessments, the results of the flipping cards game were significantly different (** p<0.01) between the normal controls (19.3±9.5 sec) and MCI subjects (30.9±18.4 sec). Three conventional affective assessments, the ADL score, Abe's behavioral and psychological symptoms of dementia (ABS) (** p<0.01) and the apathy scale (AS) (* p<0.05), could be used to discriminate the MCI subjects (ABS, 0.9±1.5; AS, 12.8±5.9) from the normal controls (ABS, 0.1±0.4; AS, 8.9±5.3). Conclusion In the present study, all four touch-panel screening tests could be employed to discriminate AD patients from normal controls, whereas only the flipping cards game was effective for distinguishing MCI subjects from normal controls. Therefore, this novel touch-panel screening test may be a more sensitive tool for detecting MCI subjects among elderly patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Computerized Touch-panel Screening Tests for Detecting Mild Cognitive Impairment and Alzheimer's Disease

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…As we previously reported, the touch panel-type screening test is very simple, takes much less time, and patients may even enjoy the tests (16,17,20). MS patients had significantly lower scores on only one cognitive assessment scale (MMSE), but showed significant delays in two touch paneltype tests (flipping cards and arranging pictures) (Fig.…”

Section: Discussionmentioning

confidence: 77%

“…Table 2 We have previously reported on cognitive assessment data obtained via touch panel-type screening tests in patients with IS (16), PD (17), and ALS (20). Specific features of each disease correlated with cognitive dysfunction, such as white matter hyperintensities in IS patients (31), longer disease duration (32) and higher disability (33) in PD patients, and severity of bulbar palsy in ALS patients (20). Cognitive impairment in MS patients has been shown to correlate with the volume of white matter lesions and the number of cortical lesions (34).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the MMSE scores significantly correlated with the flipping cards game but not with the affective function measures (Table 2). Thus, the touch panel-type screening tests may be useful and sensitive tools for detecting cognitive decline in MS patients as well as patients suffering from IS, PD, or ALS (16,17,20).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, recent reports show that MS patients score higher that healthy people on apathy tests (13,14) and NMO patients score higher than MS patients on depression scales (15). We, and other groups, have previously reported the efficacy of a computerized touch panel-type screening test for the early detection of Alzheimer's disease (AD), ischemic stroke (IS), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) (16)(17)(18)(19)(20)(21). However, such a computerized touch panel-type test has never been given to MS and NMO patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive and Affective Assessments of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) Patients Utilizing Computerized Touch Panel-type Screening Tests

et al. 2014

Self Cite

View full text Add to dashboard Cite

Objective Cognitive and affective dysfunctions are important aspects for patients with multiple sclerosis (MS) and neuromyelitis optica (NMO). Methods We herein examined the cognitive and affective ability in MS (n=35) and NMO (n=10) patients using computerized touch panel-type screening tests. Results While MS patients and normal controls (NC1, n=40) did not significantly differ in their scores from the Hasegawa dementia scale-revised (HDS-R) or the frontal assessment battery, MS patients did score significantly lower on the mini-mental state examination (MMSE). In contrast, NMO patients did not differ from the normal control group 2 (NC2, n=15) in any of the three cognitive assessments. We also examined the affective ability and found that MS patients scored significantly higher on the apathy scale (AS) compared with the NC1 group, while NMO patients scored significantly higher on the geriatric depression scale (GDS) compared with the NC2 group. Although the GDS and AS scores did not correlate with any of the cognitive assessments among MS patients, the AS scores did correlate with the MMSE and HDS-R among NMO patients. Compared with normal controls, the times to complete the flipping cards and arranging pictures games were significantly longer for MS patients but not for NMO patients. Conclusion These results indicate differences between some features of cognitive and affective dysfunctions between MS and NMO patients. Computerized touch panel-type screening tests may be a more useful and sensitive tool for the cognitive assessment of MS patients than NMO patients.

show abstract

Amyotrophic Lateral Sclerosis

Turner¹,

Pagani²

2020

PET and SPECT in Neurology

View full text Add to dashboard Cite

Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline

Cited by 13 publications

References 31 publications

Computerized Touch-panel Screening Tests for Detecting Mild Cognitive Impairment and Alzheimer's Disease

Computerized Touch-panel Screening Tests for Detecting Mild Cognitive Impairment and Alzheimer's Disease

Cognitive and Affective Assessments of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) Patients Utilizing Computerized Touch Panel-type Screening Tests

Amyotrophic Lateral Sclerosis

Contact Info

Product

Resources

About