Frontal dysfunction and psychosis proneness in CPT-linked vulnerable adolescents

Obiols, Jordi E.; Serrano, Francisco Javier Tirado; Barrantes, N.; Garcia-Marimón, M.; Gras, S.; Bosch, Esperanza; Caparrós, Beatriz; Carandell, F.

doi:10.1016/s0191-8869(97)00070-6

Cited by 12 publications

(4 citation statements)

References 27 publications

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“…Therefore, the authors suggest that performance on the WCST is more likely a feature inherent to the disease process rather than an index of genetic susceptibility to the illness. WCST-deficits in schizotypic individuals [18, 42] support the hypothesis that executive function deficits may precede the onset of schizophrenia or indicate cognitive impairments in schizophrenic-spectrum syndromes.…”

Section: Introductionmentioning

confidence: 91%

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

Klemm

Schmidt

Knappe³

et al. 2006

Eur Child Adolesc Psychiatry

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Section: Introductionmentioning

confidence: 91%

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

Klemm

Schmidt

Knappe³

et al. 2006

Eur Child Adolesc Psychiatry

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“…Among randomly selected adolescents, higher scores on the Perceptual Aberration Scale (PAS) was associated with lower dЈ scores but no symptom dimensions from the Schizotypal Personality Questionnaire were associated with dЈ on the CPT [Chen et al, 1997]. Obiols et al [1997] screened for schizotypal adolescents using CPT performance and found that subjects in the lowest decile of CPT performance had higher PAS score than those having better CPT performance.…”

Section: Cpt Deficit and Schizotypymentioning

confidence: 99%

Sustained attention deficits as markers of genetic susceptibility to schizophrenia

Chen

Faraone²

2000

Am. J. Med. Genet.

164

109

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This article reviews recent evidence regarding the potential of the visual sustained attention deficits as measured by the Continuous Performance Test (CPT) as an endophenotype of the genetic susceptibility to schizophrenia. Findings in community subjects indicate that sustained attention develops during the primary school ages, reaches its maximum around early adolescence, and declines with age after adulthood. The assertion that CPT performance deficits, and especially on the more difficult versions, are reliable and valid genetic susceptibility indicators of schizophrenia is supported by the following results: 1) CPT deficits are present in schizophrenic patients, are particularly associated with negative and disorganized symptoms, and deficits on the more difficult CPT versions are not amenable to neuroleptic treatment; 2) subjects with schizotypal personality features also exhibit CPT deficits, which are specifically associated with the negative factor of schizotypy; 3) a substantial proportion of nonpsychotic relatives of schizophrenic patients (19-34%) have CPT deficits, which can also be predicted from their probands' CPT performance. Thus, using a CPT deficits as an endophenotype of schizophrenia would not only provide a valuable measure of genetic risk, but would also greatly enhance our understanding of etiology, and may help identify susceptibility genes for schizophrenia.

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“…With regard to cognitive impairment, it has been shown that heavy cannabis users have impairments in the areas of attention, short-term memory, and psychomotor function [10][11][12]. Schizotypal subjects also have deficits in tasks of selective/focused attention, cognitive inhibition and functions of the frontal lobe [13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Cannabis Use, Schizotypal Traits, and Cognitive Function in Healthy Subjects

Maß

Bardong²,

Kindl³

et al. 2001

Psychopathology

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This research examined the relationship between cannabis use and schizotypal features. A sample of cannabis users (n = 20) was compared with a matched control group (n = 20). All participants were male students of the University of Hamburg. Subjects completed the Perceptual Aberration Scale and the Schizotypal Personality Questionnaire. A Negative Priming procedure and the Trail Making Test were carried out. A urine sample was obtained from each subject. Cannabis users exceeded controls in schizotypy scores and showed impaired neuropsychological parameters. Only within the cannabis group schizotypy scores correlated with neuropsychological parameters. Furthermore, cannabis users reported more often high-risk factors than controls. These findings indicate that among cannabis users there is an increased number of subjects with schizotypal features; schizotypal subjects seem to be more likely to use cannabis than the general population. Therefore, cannabis use may be a vulnerability indicator for schizophrenia.

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Frontal dysfunction and psychosis proneness in CPT-linked vulnerable adolescents

Cited by 12 publications

References 27 publications

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

Sustained attention deficits as markers of genetic susceptibility to schizophrenia

Relationship between Cannabis Use, Schizotypal Traits, and Cognitive Function in Healthy Subjects

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