Frontal Assessment Battery in Parkinson’s Disease: Validity and Morphological Correlates

Bezdíček, Ondřej; Růžička, Filip; Mazancova, Andela Fendrych; Roth, Jan; Dušek, Pavel; Mueller, Karsten; Růžička, Evžen; Jech, Robert

doi:10.1017/s1355617717000522

Cited by 23 publications

(15 citation statements)

References 63 publications

(75 reference statements)

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“…A potential limitation of the study concerned the use of tasks involving motor responses, such as Luria’s motor series and go-no-go FAB subtests, in which PD patients showed a declined performance. 51 However, scores of these subtests did not take into account motor slowing or reducing but focused on correct execution of the examiner’s command, thus minimizing motor demands. Visual defects in complex tasks including the ability to judge distances, visual field sensitivity, and visual processing speed should take into consideration when PD patients are assessed as well as visual-constructive skills.…”

Section: Discussionmentioning

confidence: 99%

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson’s disease

Cammisuli

Crowe

2018

NDT

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ObjectivesPatients with Parkinson’s disease (PD) present with a wide range of cognitive deficits. Cognitive impairment is recognized as an independent nonmotor aspect of the disorder and has a critical role in functional outcome and conversion into PD dementia. To date, everyday memory impairment in elderly patients with PD is underinvestigated and its relationship with executive dysfunction was not clearly explained. Our study aims at clarifying the neuropsychological pattern of everyday memory and executive deterioration in elderly patients with PD.MethodsForty nondemented PD patients (mean age 71.2 years; M:F = 29:11) and 30 well-matched controls (mean age 70.7 years; M:F = 15:15) were assessed on everyday memory (Rivermead Behavioral Memory Test [RBMT]) and executive functioning (Frontal Assessment Battery [FAB]) measures. Mann–Whitney U-tests (Bonferroni corrected) were used to compare groups on these measures and Spearman’s rank correlations were performed to highlight their associations.ResultsPD patients performed worse than controls on recall for novel tasks and geographic recall (RMBT) as well as lexical fluency and mental flexibility (FAB). Particularly, spatial orientation depending on egocentric navigation seems to be altered in PD patients. The clinical group showed poorer performances than controls in mental flexibility, sensitivity to interference, and inhibitory control. Such measures were associated with immediate and delayed recall, picture recognition, prospective memory, and orientation tasks of everyday memory.ConclusionExecutive-type difficulties and memory-type difficulties have an impact on cognitive performances of elderly patients with PD. We recommend using the RBMT and the FAB as part of routinely neuropsychological battery for assessing PD patients.

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Section: Discussionmentioning

confidence: 99%

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson’s disease

Cammisuli

Crowe

2018

NDT

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“…do not have sufficient knowledge of the Dutch language to complete questionnaires; received care from a PDNS in the past two years; have a score of <18 on the Mini-Mental State Examination (MMSE 18 ) and <12 on the Frontal Assessment Battery (FAB 19 ). have any other medical or psychiatric disorder that, in the opinion of the researcher, may compromise participation in the study.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

The Cost-Effectiveness of specialized Nursing Interventions for people with Parkinson’s Disease: the NICE-PD study protocol for a randomized controlled clinical trial

Radder¹,

Lennaerts²,

Vermeulen³

et al. 2019

Preprint

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Background Current guidelines recommend that every person with Parkinson's disease (PD) should have access to Parkinson's Disease Nurse Specialist (PDNS) care. However, there is little scientific evidence on the cost-effectiveness of PDNS care. This hampers wider implementation, creates unequal access to care and possibly leads to avoidable disability and costs. Therefore, we aim to study the (cost-)effectiveness of specialized nursing care provided by a PDNS compared to usual care (without PDNS) for people with PD in all disease stages. To gain more insight into the deployed interventions and their effects, a pre-planned subgroup analysis will be performed based on disease duration (diagnosis <5, 5-10, or >10 years ago). Methods We will perform an 18-month, single-blind, randomized controlled clinical trial in eight community hospitals in the Netherlands. A total of 240 people with PD that have not been treated by a PDNS over the past two years will be included, independent of disease severity or duration. In each hospital, 30 patients will randomly be allocated in a 1:1 ratio to either care by a PDNS (who works according to a recent guideline on PDNS care) or usual care. We will use two co-primary outcomes: quality of life (measured with the Parkinson's Disease Questionnaire-39) and motor symptoms (measured with the MDS-UPDRS part III). Secondary outcomes include non-motor symptoms, health-related quality of life, experienced quality of care, self-management, medication adherence, caregiver burden and coping skills. Data will be collected after 12 months and 18 months by a blinded researcher. A healthcare utilization and productivity loss questionnaire will be completed every 3 months. Discussion The results of this trial will have an immediate impact on the current care of people with PD. We hypothesize that, by offering more patients access to PDNS care, quality of life will increase. We also expect healthcare costs to remain equal, as increases in direct medical costs (funding additional nurses) will be offset by a reduced number of consultations with the general practitioner and neurologist. If these outcomes are reached, wide implementation of PDNS care is warranted. Trial registration ClinicalTrials.gov: NCT03830190.Registered February 5, 2019 -Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03830190.

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“…The combined effects of the degeneration in Basal Ganglia (BG) and other associated brain areas contributes to a number of motor and executive cognitive dysfunctions in PD [2]. Balance [3,4] and Executive Cognitive Function (ECF) [5,6], deteriorate in the early stages of PD. In addition, individuals with PD often need to exert executive Open J Parkinsons Dis Treatm 2(1): 006-013.…”

Section: Introductionmentioning

confidence: 99%

A new technique to test the effect of cognition on standing balance in Parkinson’s disease

Bhatt¹,

Mahana²,

Marotta³

et al. 2019

Open J Parkinsons Dis Treatm

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Objectives: (a) To determine test-retest reliability of Game Assisted Rehabilitation System (GRS) for standing balance assessment during Single Task (ST) and Dual Task (DT) conditions in people with Parkinson Disease (PD). (b) To examine the discriminant validity of the GRS to evaluate the potential interaction effect of visuomotor and cognitive loads on standing balance in people with PD. Design: The DT effect of a computer based Game-Assisted Rehabilitation System (GRS) on standing balance activities (DT) was evaluated in 30 individuals with PD (Hoehn and Yahr scale stage 2 and 3). Participants performed a series of game-based visuomotor cognitive tasks and head tracking while standing on sponge surfaces. Testing was conducted on two occasions spaced one week apart. Setting: Data collection and analysis took place in clinical lab of the University. Participants: Thirty participants diagnosed with PD and in stage 2 and stage 3 according to Hoehn and Yahr scale were recruited for the study from the local movement disorders clinic. Main outcome measure: Test-retest reliability was assessed by two-way random model Intra-Class Correlation Coeffi cient (ICC) for sway path length and cognitive outcome measures such as total residual error, response time, movement variation and success rate. Results: Moderate to high test-retest reliability was observed for performance measures of standing balance, visuomotor, and visuospatial executive cognitive functions. A signifi cant DT effect over the majority of standing balance measures and the visuomotor tasks, was observed in individuals with PD. Conclusions: This study demonstrated the reproducibility and validity of the GRS for studying DT interference as well as fall risk assessment in the PD population.

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Frontal Assessment Battery in Parkinson’s Disease: Validity and Morphological Correlates

Abstract: The FAB can be recommended as a valid instrument for PD-MCI Level I screening. FAB is sensitive to frontal lobe involvement in PD as reflected by lower gray matter density in prefrontal areas. (JINS, 2017, 23, 675-684).

Cited by 23 publications

References 63 publications

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson’s disease

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson’s disease

The Cost-Effectiveness of specialized Nursing Interventions for people with Parkinson’s Disease: the NICE-PD study protocol for a randomized controlled clinical trial

A new technique to test the effect of cognition on standing balance in Parkinson’s disease

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Frontal Assessment Battery in Parkinson’s Disease: Validity and Morphological Correlates

Abstract: The FAB can be recommended as a valid instrument for PD-MCI Level I screening. FAB is sensitive to frontal lobe involvement in PD as reflected by lower gray matter density in prefrontal areas. (JINS, 2017, 23, 675-684).

Cited by 23 publications

References 63 publications

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson&rsquo;s disease

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson&rsquo;s disease

The Cost-Effectiveness of specialized Nursing Interventions for people with Parkinson’s Disease: the NICE-PD study protocol for a randomized controlled clinical trial

A new technique to test the effect of cognition on standing balance in Parkinson’s disease

Contact Info

Product

Resources

About

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson’s disease

Spatial disorientation and executive dysfunction in elderly nondemented patients with Parkinson’s disease