Frontal Assessment Battery and Brain Perfusion Imaging in Early Dementia

Yoshida, Hidenori; Terada, Seishi; Sato, Shuhei; Kishimoto, Yuki; Ata, Toshie; Ohshima, Etsuko; Honda, Hiroki; Ishihara, Takeshi; Kuroda, Shigetoshi

doi:10.1159/000198687

Cited by 27 publications

(26 citation statements)

References 41 publications

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“…As anticipated, we found that MMSE measurements for AD were significantly lower than NC. Yoshida et al [17] reported mean MMSE scores of 20.7 ± 3.5 in AD patients (age: 75.3 ± 5.6), similar to our study. Their grouping (NC or AD) would align with our patient grouping according to MMSE criteria.…”

Section: Discussionsupporting

confidence: 91%

Relevance between Alzheimer’s Disease Patients and Normal Subjects Using Go/No-Go Tasks and Alzheimer Assessment Scores

Terasawa

Misaki²,

Murata³

et al. 2014

J Child Adolesc Behav

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It is a well-known fact that Alzheimer increases with aging. Early detection of Alzheimer has emerged as an important, because it can prevent of further deterioration of the disease. However, early detection is not always easy because of the lack of good methods to identify the early stage of Alzheimer. The screening tests of Alzheimer used around the world. These tests are relatively time-consuming, difficult and distressing for Alzheimer patients. We consider whether go/no-go task can become the screening test of the Alzheimer patient in future. This study compared results of the Mini Mental State Examination (MMSE) and the go/no-go task for between Alzheimer disease patients and normal subjects. The average reaction time and number of total error of go/no-go task that Alzheimer patients were significantly higher than among the normal subjects. About correlation with MMSE and the go/no-go task, 6 items of MMSE had correlations of 4 or more test results concerning response time, forgets and mistakes of go/no-go tasks. These characteristics suggest that there is a possibility that go/no-go tasks could be applied as a measuring method when screening for early signs of Alzheimer.

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Section: Discussionsupporting

confidence: 91%

Relevance between Alzheimer’s Disease Patients and Normal Subjects Using Go/No-Go Tasks and Alzheimer Assessment Scores

Terasawa

Misaki²,

Murata³

et al. 2014

J Child Adolesc Behav

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“…Several studies have investigated this issue [22,23,55]; however, only a few studies have discussed WMHs and FAB [56]. In the present study, we found a strong association between TFAB performance and white matter changes within frontal and lateral periventricular regions and subcortical deep brain nuclei in the patients with both MCI-V and MCI-A.…”

Section: Discussionsupporting

confidence: 54%

“…It has been widely applied in studies on various target groups [17,18,19,20,21]. Researchers have discovered that neural substrates related to performances on the FAB include both cortical and subcortical areas, such as the middle frontal gyrus, inferior frontal, insula [22], callosomarginal, and precentral regions [23]. Previous studies have also shown that the FAB is useful in differentiating AD from subcortical VaD [24].…”

Section: Introductionmentioning

confidence: 99%

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease

Hsu

Huang

et al. 2016

Dement Geriatr Cogn Disord

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Background: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have yet to be clarified. Methods: Patients with mild cognitive impairment (MCI) due to SIVD (MCI-V), MCI due to AD (MCI-A), and demographically matched controls completed the Mini-Mental State Examination, Taiwanese FAB (TFAB), Category Fluency, and Chinese Version of the Verbal Learning Test, and underwent magnetic resonance imaging. White matter hyperintensities were rated according to the Scheltens scale. Results: TFAB total scale and its Orthographical Fluency subtest were the only measures that could differentiate MCI-V from MCI-A. Discriminative analysis showed that Orthographical Fluency scores successfully identified 73.2% of the cases with MCI-V, with 85.0% sensitivity. Orthographical Fluency scores were specifically associated with lesion load within frontal periventricular, frontal deep white matter, and basal ganglia regions. Conclusion: The TFAB, and especially its 1-min Orthographical Fluency subtest, is a useful screening procedure to differentiate MCI due to SIVD from MCI due to AD. The discriminative ability is probably due to frontosubcortical white matter pathologies disproportionately involved in the two disease entities.

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“…The Frontal Assessment Battery (FAB; Dubois, Slachevsky, Litvan, & Pillon, 2000 ) is an executive screening test that, over the last years, has become widely used in neurological research (Guedj et al, 2008 ;Lima, Meireles, Fonseca, Castro, & Garrett, 2008 ;Oguro et al, 2006 ;Santangelo et al, 2009 ;Yoshida et al, 2009 ). It consists of six subtests assessing conceptualization, cognitive fl exibility, motor programming, sensitivity to interference, motor inhibitory control, and prehension behavior.…”

Section: Introductionmentioning

confidence: 99%

INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia – ERRATUM

Torralva¹,

Roca²,

Gleichgerrcht³

et al. 2009

J Int Neuropsychol Soc

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Frontal Assessment Battery and Brain Perfusion Imaging in Early Dementia

Cited by 27 publications

References 41 publications

Relevance between Alzheimer’s Disease Patients and Normal Subjects Using Go/No-Go Tasks and Alzheimer Assessment Scores

Relevance between Alzheimer’s Disease Patients and Normal Subjects Using Go/No-Go Tasks and Alzheimer Assessment Scores

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease

INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia – ERRATUM

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