2013
DOI: 10.1016/j.biopsych.2012.06.030
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Frontal-Amygdala Connectivity Alterations During Emotion Downregulation in Bipolar I Disorder

Abstract: Background The symptoms of bipolar disorder suggest dysfunction of emotion regulatory networks. In healthy control populations, down-regulation of emotional responses activates the ventral lateral prefrontal cortex (vlPFC) and dampens amygdala activation. This study investigated frontal and limbic function and connectivity during emotion down-regulation in euthymic subjects with bipolar I disorder (BPI) and healthy control subjects. Methods 30 BPI and 26 control subjects underwent fMRI scanning while perform… Show more

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Cited by 184 publications
(156 citation statements)
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“…Taken together with previous findings that connectivity between these regions is abnormal in individuals with already established bipolar disorder (Cerullo et al, 2012;Vizueta et al, 2012;Townsend et al, 2013), these findings suggest that altered right amygdala-ACC and right amygdala-left ventrolateral PFC connectivity in BO may be a risk marker for future bipolar disorder, rather than a protective marker against the development of bipolar disorder, in these youth. Future longitudinal follow-up studies are needed to determine the extent to which this is the case, however.…”
Section: Discussionsupporting
confidence: 76%
See 1 more Smart Citation
“…Taken together with previous findings that connectivity between these regions is abnormal in individuals with already established bipolar disorder (Cerullo et al, 2012;Vizueta et al, 2012;Townsend et al, 2013), these findings suggest that altered right amygdala-ACC and right amygdala-left ventrolateral PFC connectivity in BO may be a risk marker for future bipolar disorder, rather than a protective marker against the development of bipolar disorder, in these youth. Future longitudinal follow-up studies are needed to determine the extent to which this is the case, however.…”
Section: Discussionsupporting
confidence: 76%
“…For example, individuals with bipolar disorder type 1 versus healthy control subjects showed reduced inverse left amygdala-bilateral ventrolateral PFC functional connectivity during emotional downregulation (Townsend et al, 2013), individuals with bipolar disorder type 2 versus healthy control subjects had higher positive right amygdala-left ventrolateral PFC functional connectivity during emotional face processing (Vizueta et al, 2012), and right amygdala-left ventrolateral PFC connectivity increased during mania in individuals with bipolar disorder type 1 (Cerullo et al, 2012). In addition, increased right amygdala-left ventrolateral PFC functional connectivity was reported in anxious versus healthy adolescents during social evaluation anticipation (Guyer et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…An impaired white matter connectivity between frontolimbic circuits and interhemispheric structures has been observed in BD patients [98,99,100]. Studies have also shown deficits in functional connectivity in the brain of bipolar subjects during cognitive tasks and in the resting state.…”
Section: The Phenome Of Bd From the Ion Channel Perspectivementioning
confidence: 99%
“…Some earlier such studies include a look at human visual cortex responses, namely in V1, with presentation of a patterned-flash photic stimulation , imaging of the human primary motor cortex during task activation , generation (Hinke et al, 1993). More recent studies have led to developments in our understanding of many things from group-ICA results of data collected during cinema viewing (Pamilo et al, 2012) to frontalamygdala connectivity alterations during emotion down-regulation in Bipolar I Disorder (Townsend et al, 2012).…”
Section: -Abstractmentioning
confidence: 99%