Frontal activity during a verbal emotional working memory task in patients with Alzheimer's disease: A functional near-infrared spectroscopy study

Ates, Fatma E; Cangöz, Banu; Kızıl, Erguvan Tuğba Özel; Başkak, Bora; Baran, Zeynel; Özgüven, Halise Devrimci

doi:10.1016/j.pscychresns.2016.12.013

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…A lower WM task performance associated with a decreased bilateral dorsolateral PFC activation was also reported by Uemura et al [86], who proposed this finding as a predictive marker of cognitive decline. Likewise, region-specific variations (i.e., frontal, dorsolateral PFC and parietal cortex) of HbO2 levels in AD patients were observed during a single-word presentation task by Kato et al [87], while Ateş et al [88] were able to discriminate AD from HCs based on reaction times and ventral PFC activity during an emotional WMT. Oboshi et al [89] found a significant correlation between task-evoked cerebral blood flow in the PFC and α4β2 nicotinic acetylcholine receptor availability assessed by PET during a visual WM task in both AD patients and HCs.…”

Section: Cognitive Tasks-memory Taskmentioning

confidence: 86%

“…We have therefore focused our attention on the current state-of-the-art of fNIRS applications dealing with motor and cognitive disability in the most frequent chronic neurological disorders of the elderly, namely PD and the AD continuum and MS as the most frequent chronic neurological disease of young and middle-aged adults. Our results reveal that AD and MCI are the most frequently addressed conditions by a wide variety of fNIRS applications, ranging from the monitoring of tissue oxygenation and vasomotor reactivity [ 65 , 66 , 67 , 68 , 69 , 70 ], to the analysis of resting-state conditions [ 64 , 71 , 72 , 73 ], the assessment of cognitive functions by means of memory and verbal fluency tasks [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ], visuospatial functions [ 94 , 95 ] and other ecological applications [ 96 , 97 ]. Within the broad context of PD and MS, reviewed studies were more focused on the assessment of motor functions [ 51 , 53 , 54 , 55 , 56 , 109 , 110 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

“…In most of the reviewed applications, fNIRS probes were placed over the PFC, as this cortical area is mainly associated with high-level processing functions [64]. We identified 40 studies performed with a total of 977 AD and 477 MCI patients (208 amnestic MCI), as well as with 792 age-matched HC subjects (Table 2) Most studies were addressed to the monitoring of tissue oxygenation [65][66][67][68][69][70], the investigation of functional resting-state activity and connectivity [64,[71][72][73], the assessment of specific cognitive functions [74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93] such as visuospatial deficits [94,95] and additional ecological applications [96,97]. Though most studies reported cross-sectional reports, we also retrieved six longitudinal ones [98][99][100][101][102][103], thus strongly supporting the idea that fNIRS can represent a viable tool for long-term monitoring of cerebral activity from the early phases of the disease or during r...…”

Section: Fnirs In Alzheimer's Disease and Mild Cognitive Impairmentmentioning

confidence: 99%

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A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives

et al. 2020

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Background: The management of people affected by age-related neurological disorders requires the adoption of targeted and cost-effective interventions to cope with chronicity. Therapy adaptation and rehabilitation represent major targets requiring long-term follow-up of neurodegeneration or, conversely, the promotion of neuroplasticity mechanisms. However, affordable and reliable neurophysiological correlates of cerebral activity to be used throughout treatment stages are often lacking. The aim of this systematic review is to highlight actual applications of functional Near-Infrared Spectroscopy (fNIRS) as a versatile optical neuroimaging technology for investigating cortical hemodynamic activity in the most common chronic neurological conditions. Methods: We reviewed studies investigating fNIRS applications in Parkinson’s Disease (PD), Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI) as those focusing on motor and cognitive impairment in ageing and Multiple Sclerosis (MS) as the most common chronic neurological disease in young adults. The literature search was conducted on NCBI PubMed and Web of Science databases by PRISMA guidelines. Results: We identified a total of 63 peer-reviewed articles. The AD spectrum is the most investigated pathology with 40 articles ranging from the traditional monitoring of tissue oxygenation to the analysis of functional resting-state conditions or cognitive functions by means of memory and verbal fluency tasks. Conversely, applications in PD (12 articles) and MS (11 articles) are mainly focused on the characterization of motor functions and their association with dual-task conditions. The most investigated cortical area is the prefrontal cortex, since reported to play an important role in age-related compensatory mechanism and neurofunctional changes associated to these chronic neurological conditions. Interestingly, only 9 articles applied a longitudinal approach. Conclusion: The results indicate that fNIRS is mainly employed for the cross-sectional characterization of the clinical phenotypes of these pathologies, whereas data on its utility for longitudinal monitoring as surrogate biomarkers of disease progression and rehabilitation effects are promising but still lacking.

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Section: Cognitive Tasks-memory Taskmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Fnirs In Alzheimer's Disease and Mild Cognitive Impairmentmentioning

confidence: 99%

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A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives

et al. 2020

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“…Evidence for this also comes from studies using other WM tasks, such as the delayed matching to sample task or the digit verbal span task. Higher connectivity in aMCI [47], and larger HbO changes [55], [56] and greater entropy [57] have been observed in AD [57] and cognitive decline [55] compared to controls. However, similarly to the n-back task, several studies also identified hypoactivation in AD [20], [35], [58], [59], MCI [52], and specifically in aMCI [47], [50], [51].…”

Section: Discussionmentioning

confidence: 99%

A systematic review of near-infrared spectroscopy in dementia

Butters

Srinivasan

O’Brien

et al. 2022

Preprint

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Objectives. This review aimed to evaluate previous studies using Near-infrared spectroscopy (NIRS) in dementia by summarising the results, determining the consensus in the literature, and delineating if, and how, NIRS experimental and analysis methods may be improved for future studies in dementia. Methods. Three databases (PsychINFO, Medline, Embase) were searched for original research studies using NIRS in dementia and prodromal disease stages. We included both observational and randomised control trials, and studies published in English. Animal studies, conference abstracts, and reviews were excluded. Results. From 759 identified records, 80 studies using NIRS in dementia and prodromal populations across a range of activation tasks testing memory (28), word retrieval (22), and motor (7) and visuo-spatial function (4), as well as in the resting state (29) were evaluated. Across these cognitive domains, dementia patients generally showed a blunted haemodynamic response, often localised to frontal regions of interest, and a lack of task-appropriate frontal lateralisation. Prodromal stages, such as Mild Cognitive Impairment, revealed mixed results and were associated with either diminished responses or hyperactivity, accompanied by reduced cognitive function, the latter suggesting a possible compensatory neural response which is not present at the dementia stage. Conclusion. There is clear evidence of alterations in brain oxygenation in both dementia and prodromal stages across a range of cognitive domains and in the resting state, indicating an ability of NIRS to distinguish dementia from healthy ageing, or at-risk populations. A consensus as to the nature of these changes, however, is difficult to reach due to a lack of standardisation in optical techniques and processing methods. Further studies are required exploring more naturalistic settings and in a wider range of dementia subtypes.

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“…The optodes were fixed to scalp via two thermoplastic 3×3 shells, with the lowest optodes positioned along the Fp1-Fp2 line according to the international 10-20 system used in electroencephalography (Fig. 1) (18)(19)(20)(21)(22). The fNIRS device measures relative changes in oxy-Hb concentrations.…”

Section: Functional Near Infrared Spectroscopymentioning

confidence: 99%

Prefrontal activity measured by functional near infrared spectroscopy during divergent and convergent thinking in bipolar disorder"

Alıcı

Özgüven

Kale

et al. 2018

Archives of Neuropsychiatry

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Introduction: Biographical research as well as some controlled studies point out to a relationship between bipolar disorder (BD) and creativity. Neurobiological underpinnings of this relationship are unclear. Although there is no consensus on the definition of creativity, Alternative uses Test (AuT) and Remote Association Test (RAT) are frequently used to measure convergent and divergent creativity. We aimed to examine prefrontal cortex (PFC) activity with functional near-infrared spectroscopy (fNIRS) during the RAT and AuT tests in subjects with BD.Methods: We measured PFC activity in subjects with remitted BD (N=31) and healthy control subjects (N=27) with fNIRS during divergent and convergent thinking tasks (AuT and RAT respectively). We were particularly interested in the antero-posterior dissociation of the activity within the PFC according to the two task domains.Results: We found that the index subjects displayed lower performance than healthy controls during the AuT and the RAT. AuT and RAT were associated with different activities in the two groups. Anterior PFC (aPFC) activity was higher than posterior PFC (pPFC) activity during the RAT in the index group, and during the AuT in the control group. aPFC activity was negatively correlated with the RAT performance in the index group. Conclusion:Higher activity in the aPFC may be the functional neuroanatomical correlate of low convergent creativity performance in BD.

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Frontal activity during a verbal emotional working memory task in patients with Alzheimer's disease: A functional near-infrared spectroscopy study

Cited by 9 publications

References 34 publications

A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives

A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives

A systematic review of near-infrared spectroscopy in dementia

Prefrontal activity measured by functional near infrared spectroscopy during divergent and convergent thinking in bipolar disorder"

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