Frontal absences in children

Lagae, Lieven; Pauwels, Jan; Monté, CP; Verhelle, Birgit; Vervisch, Jan

doi:10.1053/ejpn.2001.0524

Cited by 43 publications

(48 citation statements)

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“…By examining brain development in CAE, this study also sheds light on the traditional notion of CAE as a benign disorder. This concept has been challenged by the evidence that on-going seizures might underlie or contribute to the cognitive, linguistic, and behavioral comorbidities of CAE (Caplan, et al 2008; Henkin, et al 2003; Henkin, et al 2005; Lagae, et al 2001; Mandelbaum and Burack 1997; Pavone, et al 2001; Williams, et al 1996; Wirrell, et al 1997). In this investigation, we used surface-based morphometry to examine whether age-related changes in gray matter (GM) tissue thickness and depth of sulcal regions at high spatial resolution across the cortex differed in children with CAE compared to healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities

Tosun

Siddarth

Toga

et al. 2011

Human Brain Mapping

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In this study, we used surface-based morphometry to examine whether age-related changes in gray matter tissue thickness and depth of sulcal regions at high spatial resolution across the cortex differed in children with childhood absence epilepsy (CAE) compared to healthy control subjects. In addition, the possibility of variable brain-cognition relationships in the CAE compared to the control group was investigated. The main findings of this study are as follows: (1) From the developmental perspective, children with CAE did not demonstrate the normal regional age-related changes involving a decrease in cortical thickness and increase in sulcal depth. (2) None of the seizure variables, including age of onset, seizure frequency, and AEDs had a significant effect on the association between age and cortical morphometry measures in the CAE population. (3) Even though the CAE group had mean VIQ and PIQ scores in the average range, our findings suggest that they use different brain regions to perform these cognitive functions compared to healthy controls. This first study on brain morphometry and cognition in children with childhood absence seizures has important implications for advancing our understanding of brain development and cognitive comorbidity in CAE, as well as for revisiting the clinical notion that CAE is a benign disorder.

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Section: Introductionmentioning

confidence: 99%

Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities

Tosun

Siddarth

Toga

et al. 2011

Human Brain Mapping

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“…Prospective studies are required using a serial grading of ictal absence manifestations before and during treatment course to provide further evidence on this point. Lagae et al (2001) found no marked differences of absence signs in patients with so called ''frontal absences'' and primary generalized absences. In addition to the evaluation of the treatment response and the long-term course, as well as the elucidation of the genetic background, we need more to learn about the involvement of neuronal networks during absence seizures.…”

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confidence: 67%

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2008

Epilepsia

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“…It has been reported that focal EEG abnormalities were found in 14.7% of the children with typical CAE (Caraballo et al, 2008); in other routine EEG studies these findings amounted to 34% or 56% of the patients with primary generalized epilepsy (Lombroso, 1997;Matur et al, 2009). This percentage was even higher in a study of Lagae et al (2001), which revealed that 80% of the children with frontal onset absences showed interictal, isolated epileptiform discharges in their EEG. The presence, specifically, of focal epileptiform spikes has been reported in a few EEG studies: Leutmezer et al (2002) reported their presence in 35% of patients with idiopathic generalized epilepsy, and 40% of patients with absence epilepsy and Yoshinaga et al (2004) found that 52% of the children diagnosed as CAE had isolated interictal focal epileptiform spikes with no statistical difference between those who responded to treatment (Valproic acid or Ethosuximide) and those who suffered from a relapse of IEDs despite being seizure free.…”

Section: Introductionmentioning

confidence: 85%

Spatiotemporal mapping of interictal epileptiform discharges in human absence epilepsy: A MEG study

2016

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a b s t r a c tPurpose: Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur in the electro-(EEG) and magnetoencephalogram (MEG) in case of focal epilepsy, are present in the MEG of children with absence epilepsy. Next, the location of the sources of the IEDs is established, and it is investigated whether the location is concordant to the earlier established focal cortical regions involved in the generalized SWDs of these children. Methods: Whole head MEG recordings of seven children with absence epilepsy were reviewed with respect to the presence of IEDs (spikes and sharp waves). These IEDs were grouped into distinct clusters, in which each contribution to a cluster yields a comparable magnetic field distribution. Source localization was then performed onto the average signal of each cluster using an equivalent current dipole model and a realistic head model of the cortical surface. Results: IEDs were detected in 6 out of 7 patients. Source reconstruction indicated most often frontal, central or parietal origins of the IED in either the left and or right hemisphere. Spatiotemporal assessment of the IEDs indicated a stable location of the averages of these discharges, indicating a single underlying cortical source. Discussion: The outcome of this pilot study shows that MEG is well suited for the detection of IEDs and suggests that their estimated sources coincide rather well with the cortical regions involved during the spikes of the SWDs. It is discussed whether the presence of IEDs, classically seen as a marker of focal epilepsies, indicate that absence epilepsy should be considered as a focal type of epilepsy, in which changes in the network are evolving rapidly.

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Frontal absences in children

Cited by 43 publications

References 0 publications

Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities

Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities

Next Month in Epilepsia

Spatiotemporal mapping of interictal epileptiform discharges in human absence epilepsy: A MEG study

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