Front Cover: Triazolecarbaldehyde Reagents for One‐Step N‐Terminal Protein Modification (ChemBioChem 9/2020)

Abstract

Hitting the target of the N terminus for protein modification is of paramount importance for constructing protein conjugates. An N‐terminal‐targeting molecule, 1H‐1,2,3‐triazole‐4‐carbaldehyde (T4AC) represented by an arrow in the Kyudo‐styled cover artwork, enables specific modification of the protein. The T4AC molecule can be prepared from structures with an amine group by a single step Dimroth rearrangement. This method provides the N‐terminal protein modification with a wide variety of functional molecules in a two‐step process. More information can be found in the communication by A. Onoda, T. Hayashi, et al. on page 1274 in Issue 9, 2020 (DOI: 10.1002/cbic.201900692).