Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019)
Abstract:The Front Cover shows a crystal of HdmX in a drop of mother liquor and the X‐ray structures of the clinical trial compounds NVP‐CGM097 and NVP‐HDM201 bound to Hdm2. The article reveals key structural states of the cancer target proteins Hdm2 and HdmX. Elucidation of the binding interactions for different chemical classes of inhibitors and of the sometimes surprising protein adaptations was key in the design and optimization of these inhibitors. For HdmX, a key crystallization additive is revealed, which enable… Show more
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