Front Cover: Stereospecific Synthesis of Fluorinated Pyrazolidinones and Isoxazolidines via a Catalyst‐Free 1,3‐Dipolar Cycloaddition of β‐Fluoroalkylated α,β‐Unsaturated 2‐Pyridylsulfones (Asian J. Org. Chem. 9/2018)
Abstract:The regio‐ and stereoselective 1,3‐dipolar reaction is an important tool to build five‐membered heterocycles. Fluoroalkylated α,β‐unsaturated building blocks were used in the 1,3‐dipolar reaction of nitrones and azomethine imines without any catalysts and additives to obtain fluorinated pyrazolidinones and isoxazolidines. High endo‐selectivity for nitrones and exo‐selectivity for azomethine imines were observed, and supported by DFT calculations of Gibbs free energy changes in CH3CN. More information can be fo… Show more
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