Front Cover: Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67‐kDa Laminin Receptor Signaling

Abstract

Mol. Nutr. Food Res. 2020, 64, 1900986 DOI: https://doi.org/10.1002/mnfr.201900986 In article 1900986, Hirofumi Tachibana and co‐workers identify a 67‐kDa laminin receptor (67LR) as a cell‐surface‐sensing receptor of Procyanidin C1 (PC1), which is found mainly in grape seeds, cacao beans, and apple peels. PC1 shows bioactivity by activating the protein kinase A (PKA)/protein phosphatase 2A (PP2A)/C‐kinase potentiated protein phosphatase‐1 inhibitor protein of 17 kDa (CPI17)/myosin regulatory light‐chain (MRLC)‐pathway through 67LR.