Front Cover: Interactive Bioconjugation at N‐Terminal Cysteines by Using O‐Salicylaldehyde Esters towards Dual Site‐Selective Functionalization (Chem. Eur. J. 67/2022)

Abstract

N‐Terminal cysteine is a hot‐spot for bioconjugation that enables the construction of complex bioconjugates. In this study, we show that O‐salicylaldehyde esters are a fast and selective reagent for modifying N‐terminal cysteine, which can be easily removed under acidic conditions, and used in dual site‐selective bioconjugations. More information can be found in the Research Article by M. J. S. A. Silva, P. M. P. Gois, and co‐workers (DOI: 10.1002/chem.202202377).