Front Cover: Double Cu‐Catalyzed Direct Csp3−H Azidation/CuAAC Reaction: A Direct Approach towards Demanding Triazole Conjugates (Chem. Eur. J. 16/2019)
Abstract:A one‐pot Cu‐catalyzed oxidative Csp3−H azidation–CuAAC process, implying unstable azide intermediates towards highly demanding 1,2,3‐triazole conjugates, is presented in this work. The artwork displays a dinosaur that symbolizes the cascade reaction. Its spines are covered by the copper catalyst, which activates all the steps of the process, from the oxidation of the substrates to the azidation and copper‐azide‐alkyne cycloaddition reaction. Meanwhile, the reagents arrive through a waterfall, which also repre… Show more
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