Front Cover: An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH (Chem. Eur. J. 66/2022)

Abstract

HgII interacting with a naturally ZnII‐containing Rad50 protein interface yields HgS4 species, the strongest metal–protein interaction known to date. It also introduces the novel manifestation of HgII mechanism of prokaryotic and eukaryotic cells. Furthermore, the substitution of naturally occurring ZnII possibly has an impact on the quaternary structure and the protein assembly process, thus disrupting the DNA‐repair mechanisms that engage the Mre11–Rad50 complex. More information can be found in the Research Article by A. Krężel and co‐workers. (DOI: 10.1002/chem.202202738).