From wings to whiskers to stem cells: why every model matters in fragile X syndrome research
Soraya O. Sandoval,
Natasha M. Méndez-Albelo,
Zhiyan Xu
et al.
Abstract:Fragile X syndrome (FXS) is caused by epigenetic silencing of the X-linked fragile X messenger ribonucleoprotein 1 (FMR1) gene located on chromosome Xq27.3, which leads to the loss of its protein product, fragile X messenger ribonucleoprotein (FMRP). It is the most prevalent inherited form of intellectual disability and the highest single genetic cause of autism. Since the discovery of the genetic basis of FXS, extensive studies using animal models and human pluripotent stem cells have unveiled the functions o… Show more
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