From Wilms to kidney tumors: which ones require a biopsy?

Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor

“… 2 The recommended treatment strategies for Wilms tumor include primary surgery and neoadjuvant chemotherapy, which can be initiated for typical patients with Wilms tumor in the absence of histological confirmation. 3 However, poor prognosis and increased relapse rates still exist in some subgroups of Wilms cancer, and about one in ten children with Wilms tumor dies of this disease despite modern treatment approaches. 4 , 5 In this sense, the development of Wilms tumor treatment is in urgent need of investigations on novel biomarkers involved in the pathogenesis of Wilms tumor.…”

How we approach paediatric renal tumour core needle biopsy in the setting of preoperative chemotherapy: A Review from the SIOP Renal Tumour Study Group

“…Percutaneous image-guided co-axial CNB through a retroperitoneal approach is the current recommendation for renal tumour biopsy, because of its high diagnostic accuracy and low complication rate, both in adults 28 for localised masses suspicious for RCC and in children to characterise masses suspicious for non-WT 3,5,6 (Table 2). Each centre is recommended to have a clear protocol imbedding these recommendations, written in conjunction with interventional radiology and pathology departments to ensure best practice and reduce the risk of complications.…”

“…4 The criteria used for deciding primary CNB instead of presumptive chemotherapy were first based on SIOP trials' clinical data and mainly based on age at diagnosis, metastatic status, and differential diagnoses such as neuroblastoma. New available epidemiological data focusing on patients' age at diagnosis 1 and recent detailed retrospective imaging data 5,6 as well as tumour volumes data from the Gesellschaft für pädiatrische Onkologie und Hämatologie (GPOH) provide the opportunity to update the recommendations for the use of CNB in children with renal neoplasms.…”

Renal cell carcinoma in children and adolescents: a retrospective study of a French–Italian series of 93 cases

“…4 Because RCC incidence increases with advancing patient age in respect to WT, in general a needle core biopsy is strongly recommended in children above 10 years of age prior to any medical treatment. [27][28][29][30] Accurate tumour classification is required to avoid unnecessary pre-operative chemotherapy and possibly perform nephron-sparing surgery in smaller RCCs, which has been shown to have a good outcome in small paediatric series. 31,32 Accurate diagnosis may also allow the inclusion of patients in trials addressing the role of targeted therapies in patients with metastatic or unresectable disease.…”