From wild wolf to domestic dog: gene expression changes in the brain

Saetre, Peter; Lindberg, Julia; Leonard, Jennifer A.; Olsson, Kjell; Pettersson, Ulf; Ellegren, Hans; Bergström, Tomas F.; Vilà, Carles; Jazin, Elena

doi:10.1016/j.molbrainres.2004.05.003

Cited by 127 publications

(105 citation statements)

References 44 publications

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“…Heterotachy relative to mouse therefore does not appear to be a distinctive feature of the human lineage. It may reflect decelerated evolution in the rodent lineage, or possibly independent adaptive evolution in the human and dog lineages 82 .…”

Section: Genesmentioning

confidence: 99%

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Lindblad‐Toh¹,

Wade²,

Mikkelsen³

et al. 2005

Nature

2,220

2,079

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Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

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Section: Genesmentioning

confidence: 99%

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Lindblad‐Toh¹,

Wade²,

Mikkelsen³

et al. 2005

Nature

2,220

2,079

View full text Add to dashboard Cite

show abstract

“…Expression patterns may also provide clues to the genetic basis of behavior. Saetre et al (2004) surveyed the expression pattern of 7762 genes in three different regions in the brains of domestic dogs and in gray wolves and coyotes. They found that the pattern of gene expression in the hypothalamus of domestic dogs was different from that in gray wolves and coyotes, whereas patterns of gene expression in the amygdala and frontal cortex were less differentiated.…”

Section: Genetics Of Behaviormentioning

confidence: 99%

“…The hypothalamus controls specific emotional, endocrinological, and autonomic responses of dogs and is highly conserved throughout mammals. The results of Saetre et al (2004) suggest that behavioral selection in dogs may have affected this central part of the brain, initiating a cascade of effects that result in some of the unique behaviors found in dogs.…”

Section: Genetics Of Behaviormentioning

confidence: 99%

The canine genome

Ostrander

Wayne²

2005

Genome Res.

200

149

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The dog has emerged as a premier species for the study of morphology, behavior, and disease. The recent availability of a high-quality draft sequence lifts the dog system to a new threshold. We provide a primer to use the dog genome by first focusing on its evolutionary history. We overview the relationship of dogs to wild canids and discuss their origin and domestication. Dogs clearly originated from a substantial number of gray wolves and dog breeds define distinct genetic units that can be divided into at least four hierarchical groupings. We review evidence showing that dogs have high levels of linkage disequilibrium. Consequently, given that dog breeds express specific phenotypic traits and vary in behavior and the incidence of genetic disease, genomic-wide scans for linkage disequilibrium may allow the discovery of genes influencing breed-specific characteristics. Finally, we review studies that have utilized the dog to understand the genetic underpinning of several traits, and we summarize genomic resources that can be used to advance such studies. We suggest that given these resources and the unique characteristics of breeds, that the dog is a uniquely valuable resource for studying the genetic basis of complex traits.

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“…] DNA arrays make it possible to study the expression levels of tens of thousands of genes simultaneously (Bowtell 1999;Eisen and Brown 1999;White 2001;Chen et al 2002;Reinke 2002). Recent studies have used DNA arrays to compare patterns of expression between closely related species (Enard et al 2002;Caceres et al 2003;Karaman et al 2003;Meiklejohn et al 2003;Ranz et al 2003;Fortna et al 2004;Khaitovich et al 2004;Nuzhdin et al 2004;Saetre et al 2004). Such multiple-species expression studies can shed light on the evolution of expression and help to identify genes that evolve under selective pressures (Rifkin et al 2003;Khaitovich et al 2004).…”

mentioning

confidence: 99%

Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles

Gilad¹,

Rifkin²,

Bertone³

et al. 2005

Genome Res.

159

149

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Interspecies comparisons of gene expression levels will increase our understanding of the evolution of transcriptional mechanisms and help to identify targets of natural selection. This approach holds particular promise for apes, as many human-specific adaptations are thought to result from differences in gene expression rather than in coding sequence. To date, however, all studies directly comparing interspecies gene expression have been performed on single-species arrays, so that it has been impossible to distinguish differential hybridization due to sequence mismatches from underlying expression differences. To evaluate the severity of this potential problem, we constructed a new multiprimate cDNA array using probes from human, chimpanzee, orangutan, and rhesus. We find a large effect of sequence divergence on hybridization signal, even in the closest pair of species, human and chimpanzee. By comparing single-species array analyses with results from multispecies arrays, we examine how estimates of differential gene expression are affected by sequence divergence. Our results indicate that naive use of single-species arrays in direct interspecies comparisons can yield spurious results.

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From wild wolf to domestic dog: gene expression changes in the brain

Cited by 127 publications

References 44 publications

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Genome sequence, comparative analysis and haplotype structure of the domestic dog

The canine genome

Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles

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