From whole blood to component therapy: The economic, supply/demand need for implementation of component therapy in sub-Saharan Africa

Erhabor, O; Adias, Teddy Charles

doi:10.1016/j.tracli.2011.06.001

Cited by 19 publications

(19 citation statements)

References 81 publications

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“…There is an imperative need to allocate knowledge and resources for blood banking to developing countries to alleviate the devastating mortality rates due to transfusion‐requiring anaemia [12, 13, 18, 62]. Basic equipment and adequately trained staff can be sufficient for safe and sustainable blood transfusion services [14, 51].…”

Section: Discussionmentioning

confidence: 99%

A study of blood transfusion services at a district hospital in Malawi

et al. 2012

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In contrast to the advanced transfusion medicine in developed nations, our findings highlight the persistent and urgent need for life-saving blood transfusions in especially young children and pregnant women in Africa. The results indicate that blood transfusion services adapted to local conditions may be a realistic solution for providing safe blood products in developing countries. Serious challenges, such as HIV transmission and sustainable organization of low-risk blood donations should be addressed to assure access to safe blood products.

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Section: Discussionmentioning

confidence: 99%

A study of blood transfusion services at a district hospital in Malawi

et al. 2012

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“…However, there are several concerns with this technique, as leukocytes have been associated with adverse effects, including febrile transfusion reactions, alloimmunization to leukocyte antigens, graftversus-host disease, and the possibility of becoming infected with other blood-borne diseases, such as HIV, hepatitis viruses, CMV, and other viruses (62). Whole-blood transfusions from convalescent to infected patients were successful during the 1995 EBOV outbreak in Kikwit, Democratic Republic of Congo.…”

Section: Whole-blood or Plasma Transfusions From Convalescent Survivorsmentioning

confidence: 99%

Backs against the Wall: Novel and Existing Strategies Used during the 2014-2015 Ebola Virus Outbreak

Wong

Kobinger

2015

Clin Microbiol Rev

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SUMMARY The 2014-2015 outbreak of Ebola virus (EBOV), originating from Guinea, is now responsible for the infection of >20,000 people in 9 countries. Whereas past filovirus outbreaks in sub-Saharan Africa have been rapidly brought under control with comparably few cases, this outbreak has been particularly resistant to containment efforts. Both the general population and primary health care workers have been affected by this outbreak, with hundreds of doctors and nurses being infected in the line of duty. In the absence of approved therapeutics, several caregivers have turned to investigational new drugs as well as experimental therapies in an effort to save lives. This review aims to summarize the candidates currently under consideration for postexposure use in infected patients during the largest EBOV outbreak in history.

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“…Plasma and cryoprecipitate are kept frozen, red cells are stored at 1-5°C, and platelets at 18-22°C with constant agitation. Recent evidence suggests that warm, fresh, whole blood may be better than component therapy for resuscitation of acidotic, hypothermic and coagulopathic trauma patients 334 and for patients needing massive transfusions. 335…”

Section: Separation Of Whole Blood Into Componentsmentioning

confidence: 99%