From video to computation of biological fluid–structure interaction problems

Dillard, Seth; Buchholz, James; Udaykumar, H. S.

doi:10.1007/s00162-015-0358-5

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Among the six papers in the area of cardiovascular hemodynamics, topics range from the hemodynamics of natural [4,8] and prosthetic valves [1], to fundamental investigations of normal [3,9] and diseased states [7] of the cardiovascular system. The paper of Dillard et al [2] describes a new method for going from videos to CFD ready models and this method is applicable to a wide variety of biological systems. Finally, the paper of Huang et al [5,6] addresses obstructive sleep apnea, a prevalent disease condition that is being increasingly targeted in modern medicine.…”

Section: The Papersmentioning

confidence: 99%

Recent developments in multiphysics computational models of physiological flows

Eldredge

Mittal

2016

Theor. Comput. Fluid Dyn.

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A mini-symposium on computational modeling of fluid-structure interactions and other multiphysics in physiological flows was held at the 11th World Congress on Computational Mechanics in July 2014 in Barcelona, Spain. This special issue of Theoretical and Computational Fluid Dynamics contains papers from among the participants of the mini-symposium. The present paper provides an overview of the mini-symposium and the special issue. 1 Overview of the mini-symposium Capabilities for numerical simulations of physiological flows have evolved tremendously in the last decade. This evolution is primarily due to notable advances in computational architecture, numerical methodologies, modeling of the rheology and elastic characteristics of biological materials, and pathways from medical imaging to flow computation. Within the advancement of numerical methodologies, there are two fronts on which developments have been particularly notable. One of these fronts involves strategies for the immersion of complex geometries in simple static grids. These so-called immersed boundary methods, which were first introduced in the 1970s but have seen a resurgence in the last decade, have gone far to address the challenges of simulation with complex moving boundaries, which are particularly troublesome in physiology. On the other front, researchers are devising new methods for coupling the fluid dynamics with other relevant physics: the structural dynamics of soft tissues, the electrophysiology of the heart muscles, and the biochemistry of fluid components, such as thrombi or aerosol particulates. The developments on these fronts have opened a wide new world for computational mechanics. Many of these advances have been fueled by productive partnerships that have emerged between engineers, physicians, and biomedical researchers, to the point that simulations are even starting to provide guidance on patient-specific diagnosis and surgical planning. The authors of this introductory paper organized a mini-symposium on the topic of multiphysical modeling of physiological flows at the 11th World Congress on Computational Mechanics, held in Barcelona in July 2014, in which the results of several such partnerships were presented over the course of two sessions. The mini-symposium brought together several researchers who are making novel contributions to the computation of flows and associated multiphysics problems in a variety of physiological contexts. The twofold objective of the mini-symposium was to highlight the state of the art in modeling of physiological flows and to provide

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Section: The Papersmentioning

confidence: 99%

Recent developments in multiphysics computational models of physiological flows

Eldredge

Mittal

2016

Theor. Comput. Fluid Dyn.

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Multi-scale modeling of shock initiation of a pressed energetic material. II. Effect of void–void interactions on energy localization

Nguyen

Seshadri

Sen

et al. 2022

Journal of Applied Physics

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Heterogeneous energetic materials (EMs) contain microstructural defects such as voids, cracks, interfaces, and delaminated zones. Under shock loading, these defects offer potential sites for energy localization, i.e., hotspot formation. In a porous EM, the collapse of one void can generate propagating blast waves and hotspots that can influence the hotspot phenomena at neighboring voids. Such void–void interactions must be accounted for in predictive multi-scale models for the reactive response of a porous EM. To infuse such meso-scale phenomena into a multi-scale framework, a meso-informed ignition and growth model (MES-IG) has been developed, where the influence of void–void interactions is incorporated into the overall reaction rate through a function, [Formula: see text]. Previously, MES-IG was applied to predict the sensitivity and reactive response of EM, where [Formula: see text] was assumed to be a function of the overall sample porosity alone. This paper performs a deeper analysis to model the strong dependency of [Formula: see text] on other factors, such as void size and shock strength. The improved model for void–void interactions produces good agreement with direct numerical simulations of the HE microstructures and, thus, advances the predictive capability of multi-scale models of the shock response and sensitivity of EM.

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From video to computation of biological fluid–structure interaction problems

Cited by 2 publications

References 45 publications

Recent developments in multiphysics computational models of physiological flows

Recent developments in multiphysics computational models of physiological flows

Multi-scale modeling of shock initiation of a pressed energetic material. II. Effect of void–void interactions on energy localization

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