From varicose veins to venous thromboembolic events

Poredoš, Pavel; Kozak, Matija; Antignani, Pier Luigi; Ježovnik, Mateja K

doi:10.23736/s0392-9590.23.04948-9

Cited by 4 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The physiological endothelial flow surface, once a compelling argument in favor of varicose veins as grafts, is juxtaposed with our findings revealing modifications within the intimal layer post-CVD affliction. The compromised endothelium, a significant etiological factor for turbulent blood flow, emerges as a critical concern, potentially paving the way for complications, particularly thrombosis [ 22 ]. Acknowledging the natural evolution of chronic venous disease and its inflammatory component [ 23 ], it becomes imperative to consider the long-term implications.…”

Section: Discussionmentioning

confidence: 99%

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

Părău,

Manzur,

Mihaicuta

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Background: Despite advancements in coronary artery bypass grafting (CABG), the optimal choice of graft material remains a subject of investigation. This study aimed to comprehensively analyze the morphological characteristics of varicose veins, exploring their potential utilization in CABG compared to healthy veins. Methods: The study included 178 patients, categorized into two groups based on healthy and varicose veins. Morphological parameters, including maximum venous diameter, wall thickness, and specific changes in tunica intima (TI), tunica media (TM), and tunica adventitia (TA), were analyzed through microscopic evaluation. Results: Varicose veins exhibited a significantly larger maximum venous diameter (p = 0.0001) and increased wall thickness (p = 0.0001) compared to healthy veins. Although varicose veins showed thickening in TI and TM, the differences were not statistically significant. Notably, disorganized smooth muscle bundles were more prevalent in varicose veins (p = 0.001), suggesting potential wall weakness. The absence of vasa vasorum in TA was significantly higher in varicose veins (p = 0.050), influencing vascularization considerations. Conclusions: The comparative morphological microscopic analysis of the specimens of healthy and varicose veins reveals significant differences between the groups, which make the conclusion of this study to plead for avoiding the use of varicose veins as a graft.

show abstract

Section: Discussionmentioning

confidence: 99%

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

Părău,

Manzur,

Mihaicuta

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…В настоящее время этого недостаточно, поскольку для разных пациентов может встречаться широкий спектр клинических сценариев и тяжести, поэтому требуется более обширный алгоритм, чтобы помочь лечащему врачу более адекватно принимать решение при консультировании. Одним из аспектов определения рисков в полёте связан со склонностью к повышенной тромбогенности [8,13,25,26], но число пассажиров, принимающих антикоагулянты, особенно антагонисты витамина К, для профилактики тромбоэмболий при фибрилляции или трепетании предсердий за последнее время выросло довольно существенно. Это приводит к тому, что актуальной становится проблема не тромбогенности, а кровотечений, при этом исследований в отношении безопасности авиаперелётов, связанных с риском кровотечений при приёме антикогаулянтов, практически нет.…”

Section: оценка пригодности к авиапутешествию при тахи-и брадиаритмияхunclassified

Evaluation of opportunity for air traveling of patients with cardiac arrhythmias

Posokhov,

Praskurnichii

2023

Vestnik aritmologii

View full text Add to dashboard Cite

The increasing use of air transport by people with cardiovascular diseases, prone to problems associated with air travel, and require more attention during the entire journey. Considerations for preventing the worsening of the condition of patients during air travel based on the available data are summarised, algorithms for preliminary risk assessment and preparation of patients with cardiac arrhythmias are given.

show abstract

Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review

Chen,

Liu,

Zhang

et al. 2024

Angiology

View full text Add to dashboard Cite

Varicose veins (VVs) have a high prevalence worldwide and have become a major medical burden. Their pathophysiology involves a complex interplay of inflammation and tissue remodeling, and current treatment is limited by its impact on the pathophysiological mechanisms. In addition, despite clear environmental factors, family history is an important risk factor, suggesting a genetic component to the risk of developing VVs. Our understanding of the pathogenesis of these diseases has benefited greatly from the expansion of population genetic studies, from pioneering family studies to large genome-wide association studies; we now find multiple risk loci for each venous disease. This review considers the pathophysiology of VVs, highlighting the current state of genetic knowledge. We also propose future directions for research.

show abstract

From varicose veins to venous thromboembolic events

Cited by 4 publications

References 48 publications

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

The Controversy of Using Insufficient Great Saphenous Veins in Coronary Artery Bypass Grafting: A Comparative Morphological Analysis of Healthy and Insufficient Veins Related to the Possibility of Using Them as a Graft

Evaluation of opportunity for air traveling of patients with cardiac arrhythmias

Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review

Contact Info

Product

Resources

About