From the Research of Cholinesterase Reactivators to the Effective Therapy of Organophosphate/Nerve Agent Poisoning

Abstract

The aim of this study is to inform about different techniques used to improve treatment of nerve agents intoxication at the Department of Toxicology. METHODS: Different methods are briefly mentioned and their importance for development of more effective reactivators is discussed. RESULTS: Basic characterization of nerve agents and therapeutic drugs is necessary after literature survey. Usage of different techniques and properties of various reactivators are studied and, on this basis, the most effective ones are tested in details and proposed for practical use. CONCLUSIONS: The results described in this study clearly demonstrate that for the development of new and more effective cholinesterase reactivators, a complex approach using different methodical attitudes is necessary.

Department of Toxicology and Military Pharmacy - Important Part of the Faculty of Military Health Sciences of the University of Defence

“…Directions for further research and new trends in the field of toxicology studied at the Department were formulated in several articles [e.g. [18][19][20][21][22][23]; these papers are of interest of various scientists as it is documented by number of citations -e.g. up to now, they were cited 350 times [22], 221 times [21] or 130 times [23].…”