From the ocean to the brain: harnessing the power of marine algae for neuroprotection and therapeutic advances

Abstract

Recent investigations have shed light on the potential of seaweed, an abundant source of bioactive compounds, to mitigate and combat neurodegenerative diseases. In this comprehensive review, the accumulating evidence supporting the neuroprotective properties of seaweed-derived compounds is evaluated and their putative mechanisms of action are elucidated. The background of this review encompasses the general understanding of neurodegenerative diseases as debilitating conditions characterized by the progressive loss of nerve cell function and viability in the central nervous system. Furthermore, the global prevalence of these diseases, encompassing Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the persistent absence of effective treatments are emphasized. To address this critical issue, an innovative avenue of research is explored by investigating the potential of seaweed and its diverse array of bioactive compounds. By examining the available literature, the evidence supporting the neuroprotective effects of seaweed-derived compounds is consolidated. These bioactive constituents exhibit promising properties in preventing and mitigating neurodegeneration. Mechanistically, their actions involve intricate pathways that contribute to neuronal survival, reduction of oxidative stress, inhibition of neuroinflammation, and modulation of protein aggregation processes. This review provides a comprehensive analysis of the mechanisms underlying the neuroprotective effects of seaweed compounds. In conclusion, this review highlights the potential of seaweed as a valuable source of neuroprotective compounds and underscores the advancements made in this burgeoning field. The identification and elucidation of the mechanisms through which seaweed compounds exert their neuroprotective effects hold promise for the development of novel therapeutic interventions. These findings transcend disciplinary boundaries, offering insight into the potential application of seaweed-derived compounds as a valuable resource for combating neurodegenerative diseases across scientific domains.

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

“…Recent advances in molecular and cellular neuroscience have shed light on potential therapeutic targets, opening avenues for developing neuroprotective agents to slow or halt the progression of these devastating brain disorders [16]. In this context, exploring natural compounds, such as those derived from red algae, emerges as a promising avenue for innovative therapeutic interventions in neurodegenerative diseases [17,18].…”

“…These examples illustrate the diverse neuroprotective properties of marine algae compounds and underscore the importance of further research to harness their therapeutic benefits for neurological diseases. Addressing challenges such as formulation optimization, pharmacokinetics, and clinical validation is essential for translating promising preclinical findings into effective patient treatments [17,19,20].…”