From the Lab to the Field: Long-Distance Transport of Sterile Aedes Mosquitoes

Maïga, Hamidou; Bakhoum, Mame Thierno; Mamaï, Wadaka; Diouf, Gorgui; Somda, Nanwintoum Séverin Bimbilé; Wallner, Thomas; Martina, Claudia; Kotla, Simran Singh; Masso, Odet Bueno; Yamada, Hanano; Sow, Bazoumana; Fall, Assane Guèye; Bouyer, Jérémy

doi:10.3390/insects14020207

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…However, methods for longer-term transport of irradiated Ae. aegypti adults are improving, which may expand opportunities for SIT programs ( Maiga et al, 2023 ). Limitations to the area that can be covered by these manual methods have led to the exploration of alternative mechanisms to facilitate broader access.…”

Section: Market Entrymentioning

confidence: 99%

Requirements for market entry of gene drive-modified mosquitoes for control of vector-borne diseases: analogies to other biologic and biotechnology products

James

Quemada

Benedict

et al. 2023

Front. Bioeng. Biotechnol.

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Gene drive-modified mosquitoes (GDMMs) are proposed as new tools for control and elimination of malaria and other mosquito-borne diseases, and promising results have been observed from testing conducted in containment. Although still at an early stage of development, it is important to begin now to consider approval procedures and market entry strategies for the eventual implementation of GDMMs in the context of disease control programs, as these could impact future research plans. It is expected that, as for other types of new products, those seeking to bring GDMMs to market will be required to provide sufficient information to allow the regulator(s) to determine whether the product is safe and effective for its proposed use. There already has been much emphasis on developing requirements for the biosafety components of the “safe and effective” benchmark, largely concerned with their regulation as genetically modified organisms. Other potential approval requirements have received little attention, however. Although GDMMs are expected to be implemented primarily in the context of public health programs, any regulatory analogies to other public health products, such as pharmaceuticals, vaccines, or chemical pesticides, must take into account the characteristics of live mosquito products. Typical manufacturing standards related to product identity, potency or quality will need to be adapted to GDMMs. Valuable lessons can be drawn from the regulatory approval processes for other whole organism and genetically modified (GM) organism products. Supply chain requirements, such as scale of production, location and design of production facilities, and methods of distribution and delivery, will be dependent upon the characteristics of the particular GDMM product, the conditions of use, and the region to be served. Plans for fulfilling supply chain needs can build upon experience in the development of other live insect products for use in public health and agriculture. Implementation of GDMMs would benefit from additional research on enabling technologies for long-term storage of mosquito life stages, efficient mass production, and area-wide delivery of GDMMs. Early consideration of these practical requirements for market entry will help to mitigate downstream delays in the development of these promising new technologies.

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Section: Market Entrymentioning

confidence: 99%

Requirements for market entry of gene drive-modified mosquitoes for control of vector-borne diseases: analogies to other biologic and biotechnology products

James

Quemada

Benedict

et al. 2023

Front. Bioeng. Biotechnol.

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Mass irradiation of adult Aedes mosquitoes using a coolable 3D printed canister

Balestrino,

Bimbilé Somda,

Samuel

et al. 2024

Sci Rep

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In the last decade, the use of the sterile insect technique (SIT) to suppress mosquito vectors have rapidly expanded in many countries facing the complexities of scaling up production and procedures to sustain large-scale operational programs. While many solutions have been proposed to improve mass production, sex separation and field release procedures, relatively little attention has been devoted to effective mass sterilization of mosquitoes. Since irradiation of pupae en masse has proven difficult to standardise with several variables affecting dose response uniformity, the manipulation of adult mosquitoes appears to be the most promising method to achieve effective and reliable sterilization of large quantities of mosquitoes. A 3D-printed phase change material based coolable canister was developed which can compact, immobilize and hold around 100,000 adult mosquitoes during mass radio sterilization procedures. The mass irradiation and compaction treatments affected the survival and the flight ability of Aedes albopictus and Aedes aegypti adult males but the use of the proposed irradiation canister under chilled conditions (6.7–11.3 °C) significantly improved their quality and performance. The use of this cooled canister will facilitate adult mass irradiation procedures in self-contained irradiators in operational mosquito SIT programmes.

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Current status of the sterile insect technique for the suppression of mosquito populations on a global scale

Bouyer

2024

Infect Dis Poverty

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Background The World Health Organization (WHO) has emphasized the urgent need for alternative strategies to chemical insecticides for controlling mosquito populations, particularly the invasive Aedes species, which are known vectors of arboviruses. Among these alternative approaches, the sterile insect technique (SIT) is experiencing rapid development, with numerous pilot trials being conducted worldwide. Main text This review aims to elucidate the principles of SIT and highlight the significant recent advancements that have facilitated its scalability. I also employ a phased conditional approach to categorize the progression of 39 projects, drawing on peer reviewed studies, press releases and direct communication with project managers. This review indicates that a substantial number of projects illustrate the efficacy of SIT in suppressing Aedes populations, with one project even demonstrating a reduction in dengue incidence. I offer several recommendations to mitigate potential failures and address the challenges of compensation and overcompensation when implementing SIT field trials. Furthermore, I examine the potential implications of male mating harassment on the effectiveness of SIT in reducing disease transmission. Conclusions This comprehensive assessment underscores the promise of SIT as a viable strategy for mosquito control. The insights gained from these trials not only contribute to the understanding of SIT’s effectiveness but also highlight the importance of careful project management and ecological considerations in the pursuit of public health objectives. Graphical Abstract

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From the Lab to the Field: Long-Distance Transport of Sterile Aedes Mosquitoes

Cited by 4 publications

References 46 publications

Requirements for market entry of gene drive-modified mosquitoes for control of vector-borne diseases: analogies to other biologic and biotechnology products

Requirements for market entry of gene drive-modified mosquitoes for control of vector-borne diseases: analogies to other biologic and biotechnology products

Mass irradiation of adult Aedes mosquitoes using a coolable 3D printed canister

Current status of the sterile insect technique for the suppression of mosquito populations on a global scale

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