From the discovery of the crustacean androgenic gland to the insulin-like hormone in six decades

Ventura, Tomer; Rosen, Ohad; Sagi, Amir

doi:10.1016/j.ygcen.2011.05.018

Cited by 120 publications

(91 citation statements)

References 60 publications

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“…The androgenic gland hormone in crustaceans has been demonstrated to be the main hormone controlling sexual differentiation and maintaining male sexual characteristics (Ventura et al, 2011). In the present study, we cloned the full-length E. sinensis IAG cDNA sequence based on hi-sequence data from the E. sinensis androgenic gland.…”

Section: Discussionmentioning

confidence: 99%

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Song¹,

Xu²,

Zang³

et al. 2018

Turk. J. Fish. Aquat. Sci.

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Androgenic gland hormone has an insulin-like structure and it is the male-specific hormone found in crustaceans. Androgenic gland hormone controls male sexual differentiation and maintains male sexual characteristics. In this study, the full-length cDNA sequence of the androgenic gland hormone gene in Eriocheir sinensis (EsIAG) was cloned. The total length of the EsIAG cDNA was 1,495 bp, encoding 151 amino acids. EsIAG has the typical conserved structure of other reported IAGs but had low sequence similarity with other crustacean IAGs. EsIAG was expressed specifically in the androgenic gland. Insulin-like growth factor binding protein 7 from the Chinese mitten crab E. sinensis (EsIGFBP7) was highly expressed in the male sex-related organs among nine crab tissues. Interactions between EsIAG and EsIGFBP7 were verified using a yeast-two hybrid assay. These results obtained in this study provide basic information about the regulatory mechanism of male sex differentiation in E. sinensis.

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Section: Discussionmentioning

confidence: 99%

“…Androgenic gland hormone (AGH) is the malespecific hormone found in crustaceans (Ventura et al, 2011). In 1999, the AGH in the isopod, Armadillidium vulgare, was demonstrated to be a two peptide glycoprotein (Martin et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Untitled

Song¹,

Xu²,

Zang³

et al. 2018

Turk. J. Fish. Aquat. Sci.

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“…Studies focusing on the AG and on the isolation of the AG hormone and its encoding transcript are accumulating, with ~20 AG-specific transcripts fully sequenced in Crustacea, over 10 of which were identified in decapods (Ventura et al, 2011;Li et al, 2012). Without exception, all of these transcripts belong to the insulin-like superfamily of peptides, which in decapods are termed insulin-like AG-specific factors (IAGs).…”

Section: Discussionmentioning

confidence: 99%

“…amphipoda, isopoda and decapoda), exhibit a unique masculine sexual differentiation and maintenance system (Ventura et al, 2011). Members of this group (~25,000 species) possess a unique malespecific androgenic gland (AG) (Charniaux-Cotton, 1962) that is known to induce masculine development.…”

Section: Introductionmentioning

confidence: 99%

An androgenic gland membrane-anchored gene associated with the crustacean insulin-like androgenic gland hormone

Rosen

Manor

Weil

et al. 2013

Journal of Experimental Biology

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SUMMARYCrustacean male sexual differentiation is governed by the androgenic gland (AG) and specifically by the secreted insulin-like AG hormone (IAG), thus far identified in several decapod species including the Australian red claw crayfish Cherax quadricarinatus (termed Cq-IAG). While a few insulin-like AG genes have been identified in crustaceans, other AG-specific genes have not been documented until now. In the present study, we describe the recent identification of a non-IAG AG-specific transcript obtained from the C. quadricarinatus AG cDNA library. This transcript, termed C. quadricarinatus membrane-anchored AG-specific factor (Cq-MAG), was fully sequenced and found to encode a putative product of 189 amino acids including a signal anchoring peptide. Expression of a recombinant GFP fusion protein lacking the signal anchor encoding sequence dramatically affected recombinant protein localization pattern. While the expression of the deleterious fusion protein was observed throughout most of the cell, the native GFP::Cq-MAG fusion protein was observed mainly surrounding the periphery of the nucleus, demonstrating an endoplasmic reticulum (ER)-like localization pattern. Moreover, co-expression of the wild-type Cq-MAG (fused to GFP) and the Cq-IAG hormone revealed that these peptides indeed co-localize. This study is the first to report a protein specifically associated with the insulin-like AG hormone in addition to the finding of another AG-specific transcript in crustaceans. Previous knowledge suggests that insulin/insulin-like factor secretion involves tissue-specific transcripts and membrane-anchored proteins. In this regard, Cq-MAGʼs tissue specificity, anchoring properties and intracellular co-localization with Cq-IAG suggest that it may play a role in the processing and secretion of this insulin-like AG hormone.

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“…Since then, the functions of TIB and TIC have never been analyzed separately. In parallel with the AG research, the chemical nature of AGH has also been studied and insulin-like androgenic gland factors (IAGs) -such as Cq-IAG isolated from Cherax quadricarinatus, Mr-IAG from M. rosenbergii, and Pm-IAG from Penaeus monodon-have been discovered in several decapods (reviewed in Ventura et al, 2011). From the Cq-IAG silencing in intersex C. quadricarinatus, it is suggested that the IAG both regulates male sex differentiation and plays the role of a gender switcher, balancing male/female characters of intersex crayfish (Rosen et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Androgenic Gland Implantation Induces Partial Masculinization in MarmorkrebsProcambarus fallaxf.virginalis

2015

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The androgenic gland in malacostracan crustacean species produces and secretes androgenic gland hormone, which is responsible for male sexual differentiation, such as the induction and development of male sexual traits, and in turn the suppression of female sexual traits. Marmorkrebs, Procambarus fallax forma virginalis, which was identified as the first parthenogenetic species in decapod crustaceans, produces only female offspring. In this study, in order to reveal whether the Marmorkrebs crayfish is sensitive to androgenic gland hormone, we transplanted an androgenic gland from a related congener, P. clarkii, to P. fallax f. virginalis. In androgenic glandimplanted specimens, partial masculinization was confirmed: the masculinization of several external sexual characteristics (i.e., thickening of the first and second pleopods; formation of reverse spines on the third and fourth pereopods) was detected, whereas that of internal sexual characteristics (e.g., the formation of ovotestes and male gonoducts) was not. Our results imply that P. fallax f. virginalis still has sensitivity to the androgenic gland hormone and, at least partly, the hormone should be able to induce male characteristics, even in parthenogenetic Marmorkrebs.

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From the discovery of the crustacean androgenic gland to the insulin-like hormone in six decades

Cited by 120 publications

References 60 publications

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An androgenic gland membrane-anchored gene associated with the crustacean insulin-like androgenic gland hormone

Androgenic Gland Implantation Induces Partial Masculinization in MarmorkrebsProcambarus fallaxf.virginalis

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