From the bottom of an old jar: A fluorometric method for the determination of creatinine in human serum

Lewińska, Izabela; Michalec, Michał; Tymecki, Łukasz

doi:10.1016/j.aca.2020.08.017

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Nowadays laboratories also routinely apply enzymatic assay kits with creatininase or creatinine deaminase 384−387 as well as GC-MS, LC-MS, and HPLC 388,389 for quantitative analysis of creatinine. 390,391 In 2016, a fluorescence turn-on probe was disclosed by the Dhara group that is applicable for the selective detection and quantification of creatinine in 10 mM PBS and biofluids. 367 The authors exploited the metal-coordinating property of creatinine, which was found to displace "Pd" from the ethylene−diamine binding station that was installed to a naphthalimide core (Figure 78).…”

Section: Amines (Other Than Amino Acids)mentioning

confidence: 99%

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Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/ medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host− guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems.

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Section: Amines (Other Than Amino Acids)mentioning

confidence: 99%

“…Alternative methods for creatinine determination in blood (and urine) are therefore still on demand. Nowadays laboratories also routinely apply enzymatic assay kits with creatininase or creatinine deaminase − as well as GC-MS, LC-MS, and HPLC , for quantitative analysis of creatinine. , …”

Section: Amines (Other Than Amino Acids)mentioning

confidence: 99%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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“…We measured creatinine values in an ex vivo perfused hemi-liver on a hemodialysis loop Section S5 (Supporting Information). In order to measure creatinine concentrations with high accuracy, we adapted the protocol by Lewinska et al [56] for continuous measurements and the spectrophotometric measurements were verified by LC-MS Figure 2i. We monitored the creatinine concentration in the blood-based perfusate of the aforementioned human hemi-liver over the first 24 h of normothermic perfusion Figure 3e.…”

Section: Real-time Patient Monitoringmentioning

confidence: 99%

A Spectrofluorometric Method for Real‐Time Graft Assessment and Patient Monitoring

Huwyler

Eden²,

Binz

et al. 2023

Advanced Science

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Biomarkers are powerful clinical diagnostics and predictors of patient outcome. However, robust measurements often require time and expensive laboratory equipment, which is insufficient to track rapid changes and limits direct use in the operating room. Here, this study presents a portable spectrophotometric device for continuous real‐time measurements of fluorescent and non‐fluorescent biomarkers at the point of care. This study measures the mitochondrial damage biomarker flavin mononucleotide (FMN) in 26 extended criteria human liver grafts undergoing hypothermic oxygenated perfusion to guide clinical graft assessment. Real‐time data identified seven organs unsuitable for transplant that are discarded. The remaining grafts are transplanted and FMN values correlated with post‐transplant indicators of liver function and patient recovery. Further, this study shows how this device can be used to monitor dialysis patients by measuring creatinine in real‐time. Our approach provides a simple method to monitor biomarkers directly within biological fluids to improve organ assessment, patient care, and biomarker discovery.

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A new method for selective determination of creatinine using smartphone-based digital image

Shariati

Khayatian

2022

Microfluid Nanofluid

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From the bottom of an old jar: A fluorometric method for the determination of creatinine in human serum

Cited by 6 publications

References 23 publications

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

A Spectrofluorometric Method for Real‐Time Graft Assessment and Patient Monitoring

A new method for selective determination of creatinine using smartphone-based digital image

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