From Tc^VII to Tc^I; facile syntheses of bis-arene complexes [^99(m)Tc(arene)₂]⁺ from pertechnetate

Abstract

Bis-arene complexes of technetium represent a fundamental class of organometallic compounds. Detailed insights into their properties are obtained due to novel and convenient synthetic routes.

[Re(η6-arene)2]+ as a highly stable ferrocene-like scaffold for ligands and complexes

“…Progress was recently made by Kudinov et al and in our group by developing a high-yield, one step procedures from [ReO 4 ] − and Zn/AlCl 3 as activation/ reduction agents. [4][5][6] Direct syntheses with functionalized arenes were reported as well, however, the high reactivity of AlCl 3 limits the compatibility to some aniline-type arenes. 7 Therefore, post-synthetic modifications are often required to introduce functionalities into the basic [Re(η 6 -C 6 H 6 ) 2 ] + framework, a comparable procedure as done with ferrocene.…”

International Year of the Periodic Table 2019: Elements Important for Life Sciences

“…2). [23,24] The chemistry of technetium would probably have remained an exotic piece of science of exclusively fundamental interest with no means for application whatsoever. Along the advent of radiopharmaceutical chemistry with more and more radionuclides becoming available, researchers at Oak Ridge National Laboratory discovered the 99 Mo/ 99m Tc generator.…”

“…Preparation of one of the first organometallic 99 Tc complexes by element transmutation [22] and its X-ray structure from 55 years later. [23] Fig. 3.…”

Technetium‐99m radiochemistry for pharmaceutical applications

“…For the preparation of this complex, pertechnetate is transferred to the arene (benzene and toluene) via an ionic liquid and the reaction takes place in the presence of AlCl 3 in the microwave. The bisarene complex formed is then extracted to the aqueous phase . No clinical application for this compound is in sight so far.…”

“…The bisarene complex formed is then extracted to the aqueous phase. 112 No clinical application for this compound is in sight so far.…”