From synapses to circuits: What mouse models have taught us about how autism spectrum disorder impacts hippocampal function
Leandra Severino,
Jinhyun Kim,
Min-Ho Nam
et al.
Abstract:Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that impacts a variety of cognitive and behavioral domains. While a genetic component of ASD has been well-established, none of the numerous syndromic genes identified in humans accounts for more than 1% of the clinical patients. Due to this large number of target genes, numerous mouse models of the disorder have been generated. However, the focus on distinct brain circuits, behavioral phenotypes and diverse experimental approaches has mad… Show more
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