From supramolecular polymers to hydrogel materials

Leenders, Christianus M. A.; Mes, Tristan; Baker, Matthew B.; Koenigs, Marcel M. E.; Besenius, Pol; Palmans, Anja R. A.; Meijer, E. W.

doi:10.1039/c3mh00103b

Cited by 46 publications

(45 citation statements)

References 34 publications

(5 reference statements)

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“…More recently, benzene‐1,3,5‐tricarboxamide (BTA) has been recognized as a useful multiple hydrogen bonding unit for formation of supramolecular hydrogels. BTA is a disk‐shaped molecule functionalized with hydrophobic alkyl spacers and oligo(ethylene glycols) to increase solubility in polar solvents, such as water .…”

Section: Supramolecular Bonding Motifsmentioning

confidence: 99%

“…In water, BTA uses a combination of its threefold hydrogen bonding, protective hydrophobic pocket, and π–π interactions between the benzene rings to self‐assemble into helical fibers ( Figure 3 ). At high enough concentrations, BTA‐based hydrogels form as a result of cross‐linking of telechelic BTAs, and much like UPy‐based hydrogels, are very sensitive to the ratio between hydrophobic and hydrophilic spacers . Recently, this method of self‐assembly has received increased attention, and has been combined with principles of DNA‐origami to enable precise control over the spatial distribution and recruitment of proteins in adaptive scaffolds.…”

Section: Supramolecular Bonding Motifsmentioning

confidence: 99%

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Self‐Healing Supramolecular Hydrogels for Tissue Engineering Applications

Saunders

Peter

2018

Macromolecular Bioscience

188

123

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Self-healing supramolecular hydrogels have emerged as a novel class of biomaterials that combines hydrogels with supramolecular chemistry to develop highly functional biomaterials with advantages including native tissue mimicry, biocompatibility, and injectability. These properties are endowed by the reversibly cross-linked polymer network of the hydrogel. These hydrogels have great potential for realizing yet to be clinically translated tissue engineering therapies. This review presents methods of self-healing supramolecular hydrogel formation and their uses in tissue engineering as well as future perspectives.

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Section: Supramolecular Bonding Motifsmentioning

confidence: 99%

Section: Supramolecular Bonding Motifsmentioning

confidence: 99%

Self‐Healing Supramolecular Hydrogels for Tissue Engineering Applications

Saunders

Peter

2018

Macromolecular Bioscience

188

123

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“…1b ) 14 . Since then, these water-soluble BTAs have proven their utility as an aqueous supramolecular polymer and have been used to study superselectivity and spatiotemporal control of monomers 15 , to elucidate the mechanisms of monomer exchange 16 and to form tailor-made hydrogels 17 .…”

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confidence: 99%

Consequences of chirality on the dynamics of a water-soluble supramolecular polymer

et al. 2015

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The rational design of supramolecular polymers in water is imperative for their widespread use, but the design principles for these systems are not well understood. Herein, we employ a multi-scale (spatial and temporal) approach to differentiate two analogous water-soluble supramolecular polymers: one with and one without a stereogenic methyl. Initially aiming simply to understand the molecular behaviour of these systems in water, we find that while the fibres may look identical, the introduction of homochirality imparts a higher level of internal order to the supramolecular polymer. Although this increased order does not seem to affect the basic dimensions of the supramolecular fibres, the equilibrium dynamics of the polymers differ by almost an order of magnitude. This report represents the first observation of a structure/property relationship with regard to equilibrium dynamics in water-soluble supramolecular polymers.

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“…The assbembly of these units is again governed by an equilibrium constant (K eq ), which is simply a ratio of association (k a ) and disassociation (k d ) kinetics. Numerous supramolecular systems are capable of creating hydrogels including host/guest interactions, 69,70 directional hydrogen bonding, 71,72 peptide amphiphiles, [73][74][75] metal-ligand coordination, 76 and small molecule gelators. 77 In theory, such systems built on weak and non-covalent interactions are well situated to quickly respond to changes in the environment or secreted factors.…”

Section: Supramolecularmentioning

confidence: 99%

“…62 Numerous non-covalent and supramolecular hydrogels are capable of displaying viscoelastic behavior. 70,71,[152][153][154][155] However, there are no known studies linking this viscoelasticity to cellular behavior. Cellular adhesion to supramolecular surfaces 156,157 and supramolecular fibers 75 has been well demonstrated, yet the correlation to viscoelasticity or timescale remains to be reported.…”

Section: Viscoelasticitymentioning

confidence: 99%