From Structure to Behavior in Basolateral Amygdala-Hippocampus Circuits

Abstract

Emotion influences various cognitive processes, including learning and memory. The amygdala is specialized for input and processing of emotion, while the hippocampus is essential for declarative or episodic memory. During emotional reactions, these two brain regions interact to translate the emotion into particular outcomes. Here, we briefly introduce the anatomy and functions of amygdala and hippocampus, and then present behavioral, electrophysiological, optogenetic and biochemical evidence from recent studies to illustrate how amygdala and hippocampus work synergistically to form long-term memory. With recent technological advances, the causal investigations of specific neural circuit between amygdala and hippocampus will help us understand the brain mechanisms of emotion-regulated memories and improve clinical treatment of emotion-associated memory disorders in patients.

Regional morphometric abnormalities and clinical relevance in Wilson's disease

“…According to our subregional shape analysis, the basomedial subregion of the left amygdala and the centromedial subregion of the right amygdala were most affected in WD. The basomedial subregion bridges the connection between the lateral nucleus and central nucleus, contributing positively to brainstem fear effectors and several anxiolytic brain regions . Atrophy of the basomedial subregion may lead to hyperorality, irritability, and disinhibition in WD.…”

“…The basomedial subregion bridges the connection between the lateral nucleus and central nucleus, contributing positively to brainstem fear effectors and several anxiolytic brain regions. 66 Atrophy of the basomedial subregion may lead to hyperorality, irritability, and disinhibition in WD. Also, depression level links negatively to the connectivity between the dorsal frontal cortex and centromedial amygdala.…”

Effect of pretreatment with intracerebroventricular injection of minocycline on morphine‐induced memory impairment in passive avoidance test: Role of P‐CREB and c‐Fos expression in the dorsal hippocampus and basolateral amygdala regions

“…On the other hand, these two regions also interact with each other in emotion‐associated memories to form long‐term memory. There are projections from the BLA to the dorsal hippocampus which is critical in the processing of emotional memory . Moreover, activation of the BLA affects hippocampal function and gene expression .…”

“…There are projections from the BLA to the dorsal hippocampus which is critical in the processing of emotional memory . Moreover, activation of the BLA affects hippocampal function and gene expression . There is a large volume of published studies describing the important role of the dorsal hippocampus and amygdala in processing and formation of memory in both animals and human beings .…”

“…45 Moreover, activation of the BLA affects hippocampal function and gene expression. 45,46 There is a large volume of published studies describing the important role of the dorsal hippocampus and amygdala in processing and formation of memory in both animals and human beings. [47][48][49] Based on the above-mentioned information, the aim of the present study was (a) to evaluate the effect of morphine on memory formation and consolidation and motor function (locomotor activity, mobility counts and velocity) in the presence or absence of minocycline, and also (b) to measure expression of P-CREB and c-Fos using immunohistochemistry technique in the rat dorsal hippocampus and the BLA in the molecular section.…”