From Stem Cell Biology to The Treatment of Lung Diseases

Esendağlı, Dorina; Günel-Özcan, Ayşen

doi:10.2174/1574888x12666170523155846

Cited by 9 publications

(7 citation statements)

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“…During chemical injury of the lung, approximately 50% of the remaining BCs have shown club or ciliated cell markers; these BCs rapidly and directly differentiate into ciliated cells during repair, while club cells dedifferentiate into BCs, which function as stem cells for the long‐term maintenance of the tracheal epithelium 15,18,19 . Rare populations of BCs have been shown to have bronchiolar airway repair effects in mouse models, 20,21 such as p63 + Krt5 + BCs 7,16,22,23 and adult tracheobronchial tissue stem cells (TSCs)/progenitor cells 24,25 . A previous report demonstrated that intravenous transplantation of a human canalicular‐stage embryonic lung cell mixture into NOD‐SCID mice can give rise to chimeric lung tissue 26 .…”

Section: Discussionmentioning

confidence: 99%

Application of autologous SOX9⁺ airway basal cells in patients with bronchiectasis

Sun

Cheng

Guo

et al. 2020

Clinical Respiratory J

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Introduction Bronchiectasis is a common condition and a leading cause of respiratory morbidity and mortality. The treatment method for bronchiectasis is mainly symptomatic treatment or surgery; however, this condition is extremely prone to recurrence. Objectives To preliminarily evaluate the safety and efficacy of applying SOX9+ autologous airway basal cells (BCs) in patients with bronchiectasis. Methods SOX9+ BCs were isolated from microscale tissue of a grade 3‐5 bronchus by bronchoscopic brushing and expanded in vitro for approximately 4 weeks. Subsequently, the autologous SOX9+ BCs were transplanted into the diseased bronchus to treat patients with bronchiectasis. Results The forced expiratory volume in1 second (FEV1)%, forced vital capacity (FVC)%, total lung capacity (TLC)%, residual volume (RV)% and RV/TLC ratio of predicted value in patients with bronchiectasis were improved at 4, 12, 24 and 48 weeks after cell transplantation, although the differences were not statistically significant (P > .05). Chest CT scans showed that the lesions in the pulmonary segment had not progressed at 4, 12 and 24 weeks after transplantation. No patients died during the follow‐up. At 4, 12 and 24 weeks after transplantation, routine blood tests, liver function tests, renal function tests and myocardial enzymatic indexes were normal (P > .05). Conclusion Transplantation of autologous SOX9+ BCs has positive effects and is safe for patients with bronchiectasis.

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Section: Discussionmentioning

confidence: 99%

Application of autologous SOX9⁺ airway basal cells in patients with bronchiectasis

Sun

Cheng

Guo

et al. 2020

Clinical Respiratory J

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“…CSCs contain the self-renewal abilities which are similar to the normal stem cells, targeting CSCs also can become an effective strategy to treat cancers. 113 Linc00662, a newly discovered LncRNA, had a strong correlation with lower overall survival rate and higher lymph node metastasis rate of patients with lung cancer. Lin28, as an RNA-binding protein and a reprogramming factor, can promote the tumourigenesis and progression in many human cancers.…”

Section: Influence the Properties Of Cancer Stem Cell (Csc)mentioning

confidence: 98%

“…Cancer stem cells (CSCs) play an important role in maintaining capacity of tumour metastasis, invasion and recurrence . Because CSCs contain the self‐renewal abilities which are similar to the normal stem cells, targeting CSCs also can become an effective strategy to treat cancers . Recently, some LncRNAs are discovered relating with the NSCLC metastasis via influencing the properties of CSCs.…”

Section: Main Regulating Manner Of Lncrnas To Influence the Metastasimentioning

confidence: 99%

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Fang

Wang

Gong

et al. 2020

J Cellular Molecular Medi

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Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.

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“…This poor prognosis is due to metastasis in the late stage of disease. Cells with a stem‐like, dormant phenotype, endowed with unlimited self‐renewal and high tumorigenic capability, are deemed responsible for post‐therapy relapse and metastatic dissemination in various cancers, including lung cancer . Therefore, the drugs that attack the cancer stem cells (CSCs) population have therapeutic benefit.…”

Section: Introductionmentioning

confidence: 99%

Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β‐catenin, and Twist pathways

Yang

Chiou

Chen³

et al. 2018

Environmental Toxicology

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Lung cancer is one of the most common cancer in cancer-related deaths worldwide, which is characterized by its strong metastatic potential. The melatonin hormone secreted by the pineal grand has an antioxidant effect and protects cells against carcinogenic substances. However, the effects of melatonin in lung cancer stemness are largely unknown. We found that melatonin reduces CD133 expression by~50% in lung cancer cell lines, while results of a sphere formation assay showed that melatonin inhibits lung cancer stemness. These effects of melatonin were reversed when the cell lines were incubated with phospholipase C (PLC), ERK/p38, and a β-catenin activator. Transfection with Twist siRNA augmented the inhibitory effects of melatonin, indicating that melatonin suppresses lung cancer stemness by inhibiting the PLC, ERK/p38, β-catenin, and Twist signaling pathways. We also found CD133 expression is positively correlated with Twist expression in lung cancer specimens. Melatonin shows promise in the treatment of lung cancer stemness and deserves further study. K E Y W O R D S lung cancer, melatonin, stemness, Twist 1 | INTRODUCTION Lung cancer is a major occasion of cancer mortality. Non-small cell lung cancer (NSCLC) is the most general type of lung cancer, accounting for more than 85% of all lung cancers. 1,2 Although chemotherapy and radiotherapy have improved lung cancer treatment over the past few decades, survival rates remain poor, with approximately 15% of patients remaining alive at 5 years after diagnosis. This poor prognosis is due to metastasis in the late stage of disease. Cells with a stem-like, dormant phenotype, endowed with unlimited self-renewal and high tumorigenic capability, are deemed responsible for post-therapy relapse and metastatic dissemination in various cancers, including lung cancer. 3-5 Therefore, the drugs that attack the cancer stem cells (CSCs) population have therapeutic benefit.Melatonin (N-acetyl-5-methoxytryptamine), a hormone secreted by the pineal grand and other organs, is produced in a circadian rhythm in reply to photic signaling from the retina. 6,7 Melatonin is important for controlling the immune system 8-10 and has an antioxidant effect. 11,12 This agent protects cells against carcinogenic substances and inhibits the development, metastasis, invasion and angiogenesis of many types

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From Stem Cell Biology to The Treatment of Lung Diseases

Abstract: Though not yet approved for clinical usage, the application of stem cell therapies shown to be safe and with minimal adverse effects could be an alternative treatment to many lung diseases giving a hope for the future of severely ill patients refractory to the current therapies.

Cited by 9 publications

References 0 publications

Application of autologous SOX9⁺ airway basal cells in patients with bronchiectasis

Application of autologous SOX9⁺ airway basal cells in patients with bronchiectasis

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β‐catenin, and Twist pathways

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From Stem Cell Biology to The Treatment of Lung Diseases

Abstract: Though not yet approved for clinical usage, the application of stem cell therapies shown to be safe and with minimal adverse effects could be an alternative treatment to many lung diseases giving a hope for the future of severely ill patients refractory to the current therapies.

Cited by 9 publications

References 0 publications

Application of autologous SOX9+ airway basal cells in patients with bronchiectasis

Application of autologous SOX9+ airway basal cells in patients with bronchiectasis

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β‐catenin, and Twist pathways

Contact Info

Product

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Application of autologous SOX9⁺ airway basal cells in patients with bronchiectasis

Application of autologous SOX9⁺ airway basal cells in patients with bronchiectasis