From St. John’s wort to tomato and from Rhodiola to cranberry

Weixlbaumer, Verena; Draxler, Lukas; Zeitlinger, Markus; Prantl, Benedikt

doi:10.1007/s00508-020-01633-w

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Herbal medicine (HM) involves the use of plants or herbs to manage health conditions (Weixlbaumer et al, 2020). HM can provide adjunctive therapy for adults with PSD, as concluded by a meta-analysis using search terms such as herbal medicine, phytotherapy, plant extracts, medicinal plants, Chinese herbal drugs, Chinese traditional medicine, Ginkgo biloba, and Eleutherococcus (Zhang et al, 2023).…”

Section: Alternative Medicinementioning

confidence: 99%

A comprehensive overview of post-stroke depression treatment options

Raggi,

Serretti,

Ferri

2023

International Clinical Psychopharmacology

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Nearly one-third of all stroke patients develop depression at any time after a stroke, and its presence is associated with unfavorable outcomes. This narrative review aims to provide a synopsis of possible pharmacological and non-pharmacological treatment modalities for post-stroke depression (PSD). Several studies have demonstrated the efficacy and safety of selective serotonin reuptake inhibitors in treating the symptoms of this clinical condition. The treatment of PSD has been recently enhanced by innovative approaches, such as cognitive-behavioral therapy, virtual reality, telehealth, repetitive transcranial magnetic stimulation, and non-conventional therapies, which might improve depression treatment in stroke survivors. Future high-quality randomized controlled trials are necessary to confirm this hypothesis.

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Section: Alternative Medicinementioning

confidence: 99%

A comprehensive overview of post-stroke depression treatment options

Raggi,

Serretti,

Ferri

2023

International Clinical Psychopharmacology

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“…St John’s wort extract is widely promoted as a ‘natural antidepressant’ which lacks unwanted autonomic cardiac effects. It displays non-inferior efficacy in mild to moderate depression when compared to standard antidepressant drugs (Weixlbaumer et al, 2020 ). The pharmacological mechanism of the herbal drug has not been yet been understood despite known pleiotropic effects of the main psychoactive ingredients hypericin and hyperforin on the aminergic, GABAergic and glutamatergic neurotransmitter systems (Butterweck, 2003 ).…”

Section: Review Of Our Research and Findingsmentioning

confidence: 99%

Heart Rate Variability: A Measure of Cardiovascular Health and Possible Therapeutic Target in Dysautonomic Mental and Neurological Disorders

Siepmann

Weidner

Petrowski

et al. 2022

Appl Psychophysiol Biofeedback

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Mental illness such as depression and anxiety as well as cerebrovascular disease are linked to impairment of neurocardiac function mediated by changes to the autonomic nervous system with increased sympathetic and decreased parasympathetic activity. Autonomic neurocardiac function can be evaluated by computing heart rate variability (HRV). Over the past decades, research has demonstrated the diagnostic value of HRV as independent predictor of cardiovascular mortality and as disease marker in progressive autonomic nervous system disorders such as Parkinson’s disease. Here we summarize our studies on HRV and its therapeutic modulation in the context of psychopharmacology as well as psychiatric and neurological disorders to honor the life of Professor Evgeny Vaschillo, the true pioneer of HRV research who sadly passed away on November 21st, 2020.

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“…One of the best-known and popular traditional medicinal plants used as an adaptogen to treat stress-related tiredness is Rhodiola rosea L. (golden root) ( 2 ). For medicinal purposes, the rhizome of the plant (underground stem) is mainly used, from which about 140 substances have been isolated, among which the most important are salidroside, rosin, rosavin and p -tyrosol.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rhodiola rosea Rhizomes and Punica granatum Fruit Peel on the Metabolic Processes and Physiological Activity of Rats Fed with Excessive Fat Diet

Lieshchova

Brygadyrenko

2023

Food Technol. Biotechnol. (Online)

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Research background. P. granatum and Rh. rosea – as well as a number of other species of medicinal plants – exert an array of biological effects: adaptogenic, antioxidant and anti-inflammatory. However, there are not enough contemporary studies of their influence on metabolic processes, especially in cases of imbalanced diet. Lipid dysregulation is the main reason for many diseases, including obesity, cardiovascular disorders, non-alcoholic fatty liver disease, hypertension, atherosclerosis and insulin resistance. Recently, a growing amount of evidence suggests the positive effects of certain natural nutrients on lipid metabolism. The work aims to define the general effect of Rh. rosea and P. granatum fruit peel on physiological activity and metabolic processes in model animals fed with excessive fat diet. This study is relevant for the development of drugs and food additives for treatment and prophylaxis of metabolism disorders. Experimental approach. In a 30-day experiment, we determined the effect of Rhodiola rosea L. rhizomes and Punica granatum L. fruit peel on the physiological activity and metabolic processes of 24 laboratory rats consuming a high-fat diet. The physical activity was evaluated according to the mass gain of animals and change in the relative mass of the internal organs, and also the functional condition of the central nervous system, as demonstrated by the indicators of the locomotor activity and emotional status, determined in the Open Field test. The influence on the metabolic processes was revealed by biochemical and clinical blood analyses. Results and conclusions. Body mass of rats fed with Rh. rosea reached 125.8 % of the initial body mass; when fed on P. granatum, it reached 123.9 %; and in the control group, only 111.5 % of the initial body mass. The rhizomes of Rh. rosea in the diet of male rats during the month of the experiment did not cause significant changes in the relative organ mass, and the peel of P. granatum fruits led to a decrease in the thymus relative mass, as well as liver, and brain. Rh. rosea rhizomes in the rats' diet led to an increase in the activity of alkaline phosphatase, and also to a decrease in the concentration of urea and urea nitrogen. Diet supplemented with Rh. rosea also contributed to a strong decrease in plasma concentrations of bilirubin and triglycerides (up to 57.0 % compared with the concentration in the control group). The rhizomes of Rh. rosea contributed to an unreliable decrease in the atherogenicity index. The fruit peel of P. granatum also strongly has increased alkaline phosphatase activity and reduced plasma triglyceride concentrations. In addition, in rats consuming the peel of P. granatum, blood glucose concentration decreased. Under the influence of P. granatum, a strong increase in the atherogenic index (up to 518.6 % of the control) was observed because of a decrease in the high-density lipoproteins’ concentration (up to 57.1 %) and a simultaneous elevation of low-density lipoproteins’ concentration (up to 158.3 % of the control). Open field test between groups remained without significant changes. Novelty and scientific contribution. The results indicate that the roots of Rh. rosea and peel of P. granatum are safe as food additives to high-fat diet and cause no pathological changes and side-effects, and at the same time significantly influences the metabolic processes (lipid and carbohydrate). Our study theoretically substantiates the use of Rh. rosea roots and P. granatum peel for the production of nutraceutical and pharmacological products for the correction of metabolic disorders of people and animals. Doses and periods of their application require further research.

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From St. John’s wort to tomato and from Rhodiola to cranberry

Cited by 4 publications

References 26 publications

A comprehensive overview of post-stroke depression treatment options

A comprehensive overview of post-stroke depression treatment options

Heart Rate Variability: A Measure of Cardiovascular Health and Possible Therapeutic Target in Dysautonomic Mental and Neurological Disorders

Effect of Rhodiola rosea Rhizomes and Punica granatum Fruit Peel on the Metabolic Processes and Physiological Activity of Rats Fed with Excessive Fat Diet

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