From Specificity to Sensitivity: How Acute Stress Affects Amygdala Processing of Biologically Salient Stimuli

Marle, Hein J. F. van; Hermans, Erno J.; Qin, Shaozheng; Fernández, Guillén

doi:10.1016/j.biopsych.2009.05.014

Cited by 270 publications

(206 citation statements)

References 48 publications

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“…Interestingly, we did not find main effects of stress on amygdala reactivity, which is in contrast to studies reporting enhanced amygdala activity under stress (van Marle et al, 2009). However, this latter study tested female participants only and there is initial evidence for sex-specific effects of stress-related neuromodulators on face processing in the amygdala (Schwabe et al, 2013a).…”

Section: Effects Of Mineralocorticoid Receptor Blocking In Humans S Vcontrasting

confidence: 99%

Blocking the Mineralocorticoid Receptor in Humans Prevents the Stress-Induced Enhancement of Centromedial Amygdala Connectivity with the Dorsal Striatum

Vogel

Klumpers

Krugers

et al. 2014

Neuropsychopharmacol

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Two research lines argue for rapid stress-induced reallocations of neural network activity involving the amygdala. One focuses on the role of norepinephrine (NE) in mediating a shift towards the salience network and improving vigilance processing, whereas the other focuses on the role of cortisol in enhancing automatic, habitual responses. It has been suggested that the mineralocorticoid receptor (MR) is critical in shifting towards habitual responses, which are supported by the dorsal striatum. However, until now it remained unclear whether these two reallocations of neural recourses might be part of the same phenomenon and develop immediately after stress onset. We combined methods used in both approaches and hypothesized specifically that stress would lead to rapidly enhanced involvement of the striatum as assessed by amygala-striatal connectivity. Furthermore, we tested the hypothesis that this shift depends on cortisol interacting with the MR, by using a randomized, placebo-controlled, full-factorial, between-subjects design with the factors stress and MRblockade (spironolactone). We investigated 101 young, healthy men using functional magnetic resonance imaging after stress induction, which led to increased negative mood, heart rate, and cortisol levels. We confirmed our hypothesis by revealing a stress-by-MR-blockade interaction on the functional connectivity between the centromedial amygdala (CMA) and the dorsal striatum. Stress rapidly enhanced CMA-striatal connectivity and this effect was correlated with the stress-induced cortisol response, but required MR availability. This finding might suggest that the stress-induced shift described by distinct research lines might capture different aspects of the same phenomenon, ie, a reallocation of neural resources coordinated by both NE and cortisol. Neuropsychopharmacology (2015) 40, 947-956;

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Section: Effects Of Mineralocorticoid Receptor Blocking In Humans S Vcontrasting

confidence: 99%

Blocking the Mineralocorticoid Receptor in Humans Prevents the Stress-Induced Enhancement of Centromedial Amygdala Connectivity with the Dorsal Striatum

Vogel

Klumpers

Krugers

et al. 2014

Neuropsychopharmacol

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“…The present stress induction method closely corresponds to the determinants of the human stress response as described by Mason (42) (i.e., unpredictability, novelty, and uncontrollability). Moreover, previous studies have shown that this method elicits a measurable physiological and psychological stress response (26)(27)(28).…”

Section: Methodsmentioning

confidence: 94%

“…Acute stress was induced by showing short movie clips with highly aversive content and a self-reference instruction, which directly preceded and followed the task. This method of stress induction has been shown previously to elicit an acute stress response (26)(27)(28). To assess the effectiveness of this method in our study, subjective negative affect, salivary cortisol and α-amylase, and heart rate were measured.…”

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confidence: 99%

“…We investigated the effect of acute stress on amygdala reactivity using a task that robustly engages the amygdala (26), in which participants passively viewed photographed faces with expressions morphing dynamically into either happy or fearful. During this task, we measured conventional fMRI based on blood oxygen leveldependent (BOLD) contrast to assess phasic responses of neural activity induced by changing experimental conditions.…”

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Acute stress modulates genotype effects on amygdala processing in humans

Cousijn

Rijpkema

Qin

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Probing gene-environment interactions that affect neural processing is crucial for understanding individual differences in behavior and disease vulnerability. Here, we tested whether the current environmental context, which affects the acute brain state, modulates genotype effects on brain function in humans. We manipulated the context by inducing acute psychological stress, which increases noradrenergic activity, and probed its effect on tonic activity and phasic responses in the amygdala using two MRI techniques: conventional blood oxygen level-dependent functional MRI and arterial spin labeling. We showed that only carriers of a common functional deletion in ADRA2B, the gene coding for the α2b-adrenoreceptor, displayed increased phasic amygdala responses under stress. Tonic activity, reflecting the perfusion of the amygdala, increased independently of genotype after stress induction. Thus, when tonic activity was heightened by stress, only deletion carriers showed increased amygdala responses. Our results demonstrate that genetic effects on brain operations can be state dependent, such that they only become apparent under specific, often environmentally controlled, conditions. ADRA2B | gene-environment interactions | fMRI | imaging genetics

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“…† Mark Rijpkema, 5 Robert Oostenveld, 5 Guillén Fernández 1,2 Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain.…”

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confidence: 99%

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From Specificity to Sensitivity: How Acute Stress Affects Amygdala Processing of Biologically Salient Stimuli

Cited by 270 publications

References 48 publications

Blocking the Mineralocorticoid Receptor in Humans Prevents the Stress-Induced Enhancement of Centromedial Amygdala Connectivity with the Dorsal Striatum

Blocking the Mineralocorticoid Receptor in Humans Prevents the Stress-Induced Enhancement of Centromedial Amygdala Connectivity with the Dorsal Striatum

Acute stress modulates genotype effects on amygdala processing in humans

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