From small molecules to polymeric probes: recent advancements of formaldehyde sensors

Pan, Swagata; Roy, Subhadip; Choudhury, Neha; Behera, Priyanka; Sivaprakasam, Kannan; Ramakrishnan, Latha; De, Priyadarsi

doi:10.1080/14686996.2021.2018920

Cited by 14 publications

(12 citation statements)

References 89 publications

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“…The application of this approach has yielded remarkable results. The FA-sensor-supplemented polymer structures are highly biocompatible [ 112 , 113 ]. Thus, it has been shown that these polymers can efficiently detect endogenous FA in cell culture or in living organisms (e.g., zebrafish).…”

Section: From In Vitro To In Cellulomentioning

confidence: 99%

“…Thus, it has been shown that these polymers can efficiently detect endogenous FA in cell culture or in living organisms (e.g., zebrafish). Liu et al [ 114 ] recently reviewed in detail how to use polymer chemistry to create a suitable FA measurement model, and Pan et al [ 113 ] summarized data on the progress in polymer-based FA-sensors and discussed the advantages of polymeric probes for FA detection in vitro and in vivo. The polymer-based approach opens a new horizon for bioimaging and expands the field of application of the Hantzsch reaction.…”

Section: From In Vitro To In Cellulomentioning

confidence: 99%

“…Recentl excellent reviews by Xu et al [ 115 ], Manna et al [ 95 ] and Pan et al [ 113 ] summarized advances on fluorescent probes and sensors, which were developed in the last decade and can be used to monitor FA in a variety of objects both in vitro and in vivo. Most of the substances described in these reviews are suitable for living cells and were demonstrated to be successfully applied for FA level assessment.…”

Section: From In Vitro To In Cellulomentioning

confidence: 99%

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Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms

Lipskerov

Sheshukova

Komarova

2022

IJMS

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Formaldehyde (FA) is the simplest aldehyde present both in the environment and in living organisms. FA is an extremely reactive compound capable of protein crosslinking and DNA damage. For a long time, FA was considered a “biochemical waste” and a by-product of normal cellular metabolism, but in recent decades the picture has changed. As a result, the need arose for novel instruments and approaches to monitor and measure not only environmental FA in water, cosmetics, and household products, but also in food, beverages and biological samples including cells and even organisms. Despite numerous protocols being developed for in vitro and in cellulo FA assessment, many of them have remained at the “proof-of-concept” stage. We analyze the suitability of different methods developed for non-biological objects, and present an overview of the recently developed approaches, including chemically-synthesized probes and genetically encoded FA-sensors for in cellulo and in vivo FA monitoring. We also discuss the prospects of classical methods such as chromatography and spectrophotometry, and how they have been adapted in response to the demand for precise, selective and highly sensitive evaluation of FA concentration fluctuations in biological samples. The main objectives of this review is to summarize data on the main approaches for FA content measurement in liquid biological samples, pointing out the advantages and disadvantages of each method; to report the progress in development of novel molecules suitable for application in living systems; and, finally, to discuss genetically encoded FA-sensors based on existing natural biological FA-responsive elements.

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Section: From In Vitro To In Cellulomentioning

confidence: 99%

Section: From In Vitro To In Cellulomentioning

confidence: 99%

Section: From In Vitro To In Cellulomentioning

confidence: 99%

See 1 more Smart Citation

Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms

Lipskerov

Sheshukova

Komarova

2022

IJMS

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“…Also, optical chemosensors are cost-effective and easier to handle than chromatographic and spectroscopic instrumentations, which are larger, more expensive, and more difficult to operate . Pan et al specifically worked on amine-based probes by focusing on their polymeric versions . Meanwhile, Lin et al proposed a unique dimension and worked on pillar arenes for FA detection .…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in the Development of Organic Chemosensors for Formaldehyde Detection

et al. 2023

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Formaldehyde has become a prominent topic of interest because of its simple molecular structure, release from various compounds in the near vicinity of humans, and associated hazards. Thus, several researchers designed sophisticated instrumentations for formaldehyde detection that exhibit real-time sensing properties and are cost-effective and portable with high detection limits. On these grounds, this review is centered on an analysis of optical chemosensors for formaldehyde that specifically fall under the broad spectrum of organic probes. In this case, this review discusses different organic functionalities, including amines, imines, aromatic pillar arenes, β-ketoesters, and β-diketones, taking part in various reaction mechanisms ranging from aza-Cope rearrangement and Schiff base and Hanztch reactions to aldimine condensation. In addition, this review distinguishes reaction mechanisms according to photophysical phenomena, that is, aggregation-induced emission, photoinduced electron transfer, and intramolecular charge transfer. Furthermore, it addresses the instrumentation involved in gas-based and liquid formaldehyde detection. Finally, it discusses the gaps in existing technologies followed by a succinct set of recommendations for future research.

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“…Fluorescent molecules provide excellent tools for the visual determination of formaldehyde . Most of the common formaldehyde reactive fluorescent probes use a carbonyl reaction combining formaldehyde with amino groups, such as BODIPY dyes, benzimidazopyridine, naphthyridine, and other strongly fluorescent molecules modified with amino groups. − By combining fluorescein with supramolecules, which have the advantage of providing a cavity for the binding of guest molecules, many novel recognition systems have been developed as sensors for identifying formaldehyde, due to the simplicity of preparation and detection, fast response, high sensitivity, and good selectivity: for example, supramolecular formaldehyde detectors using the interactions between quantum dots and gold nanoparticles, Eu–Zr bimetallic luminescent center complexes, Cu–MOF catalytic sensors, tridentate pyridine based supramolecular polymer detectors with triamide groups, etc. However, it is still a challenge to design a hybrid supramolecular system that integrates fluorescence detection and absorption of formaldehyde.…”

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confidence: 99%

An Imidazole-Based Triangular Macrocycle for Visual Detection of Formaldehyde

Zhang

et al. 2022

Inorg. Chem.

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Highly selective detection of formaldehyde utilizing supramolecules has promising applications in both environmental monitoring and biomonitoring areas. Herein we present a new class of imidazole-based, coordination-driven, self-assembled triangular macrocycles with specific recognition of formaldehyde. The visible fluorescence change to the naked eye from yellow to green-yellow occurs via an unusual reversible hydroxymethylation reaction of imidazole, whereas the corresponding imidazole ligands show no fluorescence change. This study provides a new method for efficient formaldehyde detection by utilizing imidazole-based coordination supramolecules.

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From small molecules to polymeric probes: recent advancements of formaldehyde sensors

Cited by 14 publications

References 89 publications

Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms

Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms

Recent Progress in the Development of Organic Chemosensors for Formaldehyde Detection

An Imidazole-Based Triangular Macrocycle for Visual Detection of Formaldehyde

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