From sandwich complexes to dendrimers: journey toward applications to sensing, molecular electronics, materials science, and biomedicine

Abstract

This review links various areas of inorganic chemistry around the themes developed by our research group during the last four decades. It is firstly based on the electronic structure of...

Triiron Complex with N-Ferrocenyl Aminocarbyne Ligand Bridging a Diiron Core: DFT, Electrochemical, and Biological Insights

“…The ferrocene skeleton (FeCp 2 , Cp = η 5 -C 5 H 5 ) possesses unique redox behavior, low toxicity, and outstanding stability, and these properties have stimulated research in diverse fields. − In particular, the ferrocene scaffold has garnered significant attention for formulating new anticancer metallodrugs. , Ferrocenyl compounds typically exert their antiproliferative activity by undergoing Fe II to Fe III oxidation in the tumor environment; this electron transfer disrupts cellular redox homeostasis, ultimately leading to cell death. , To harness the beneficial characteristics of ferrocene and create synergistic effects, synthetic chemists have pursued conjugation strategies. Basically, these strategies involve modifying one or two cyclopentadienyl rings of FeCp 2 with suitable functionalities (e.g., phosphine groups, tetradentate Schiff bases, and NHCs) capable of binding to another metal center. , Concerning potential medicinal applications, various metal structures with documented biological activities have been attached to ferrocene.…”

Metallodendrimers Unveiled: Investigating the Formation and Features of Double-Decker Silsesquioxane-Based Silylferrocene Dendrimers

“…Ferrocene, as a representative of a classic organometallic compound, of a sandwich aromatic structure with iron as the central atom, is characterized by undoubtedly impressive redox properties and chemical and thermal stability. Ferrocene-based compounds found many applications from fuel additives, pharmaceuticals, catalysts, capacitors, and porous systems for dyes/heavy ion removal to electrochemical sensors. − However, ferrocene itself shows poor adhesion to surfaces. Therefore, its modification using diverse systems from oligo- and polysiloxanes and graphene oxide to dendrimers makes it possible to enhance this and other properties. ,− …”

“…The arms of the dendritic systems can be built of diverse units such as polyaminoester, carbosilanes, or polyamidoamines. − They are characterized by high molecular weights that correspond with a number of electroactive ferrocene terminal groups exhibiting good solubility and adhesion to electrodes . There are scientific reports on the use of ferrocene dendrimers as electrode modifiers for direct quantification of DEHP [di(2-ethylhexyl)phtalate], for monitoring of ATP 2– , glucose, boric acid, oxidation-triggered drug delivery, and anion recognition, or as a catalyst. , …”

“…16 There are scientific reports on the use of ferrocene dendrimers as electrode modifiers for direct quantification of DEHP [di(2ethylhexyl)phtalate], 2 for monitoring of ATP 2− , 17 glucose, 18 boric acid, 19 oxidation-triggered drug delivery, 20 and anion recognition, 21 or as a catalyst. 3,22 Organosilicon compounds are often used in dendritic systems, e.g., silanes, cyclosiloxanes, 1,3,5-trisilacyclohexane, or more complex structures such as silsesquioxanes. 7,15,23−28 They are known as polyhedral oligomeric silsesquioxanes (SQs, POSS) and represent a class of hybrid organic− inorganic compounds that have garnered significant attention in the field of materials chemistry.…”

“… 16 There are scientific reports on the use of ferrocene dendrimers as electrode modifiers for direct quantification of DEHP [di(2-ethylhexyl)phtalate], 2 for monitoring of ATP 2– , 17 glucose, 18 boric acid, 19 oxidation-triggered drug delivery, 20 and anion recognition, 21 or as a catalyst. 3 , 22 …”