From resonance to chaos: modulating spatiotemporal patterns through a synthetic optogenetic oscillator
Jung Hun Park,
Gábor Holló,
Yolanda Schaerli
Abstract:Oscillations are a recurrent phenomenon in biological systems across scales, including circadian clocks, metabolic oscillations and embryonic genetic oscillators. Despite their fundamental significance in biology, deciphering core principles of biological oscillators is very challenging due to the multiscale complexity of genetic networks and the difficulty in perturbing organisms in vivo. In this study, we tackle this challenge by re-designing the well-characterised synthetic oscillator, known as 'repressilat… Show more
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