From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo

Ali, Imran; Hurmerinta, Teija T.; Nurmi, Tarja; Berglund, Marika; Rüegg, Joëlle; Poutanen, Matti; Halldin, Krister; Mäkelä, Sari; Damdimopoulou, Pauliina

doi:10.1016/j.toxlet.2016.04.020

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Cd has been classified as a known carcinogen [ 52 ]. The increased hospitalization for breast cancer in regions with higher Cd pollution is biologically plausible as Cd is involved in the carcinogenesis of breast cancer by activating ER [ 53 , 54 ], inducing cell proliferation, differentiation, and apoptosis [ 55 , 56 ], and modulating gene expression. Epidemiological studies have also indicated that urinary Cd levels were higher in breast cancer patients than in normal controls [ 57 , 58 ], while breast cancer tissue had four times higher Cd levels than surrounding healthy tissue [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Spatial patterns and the associated factors for breast cancer hospitalization in the rural population of Fujian Province, China

et al. 2023

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Background Despite the known increasing incidence of breast cancer in China, evidence on the spatial pattern of hospitalization for breast cancer is scarce. This study aimed to describe the disparity of breast cancer hospitalization in the rural population of Southeast China and to explore the impacts of socioeconomic factors and heavy metal pollution in soil. Methods This study was conducted using the New Rural Cooperative Medical Scheme (NRCMS) claims data covering 20.9 million rural residents from 73 counties in Southeast China during 2015–2016. The associations between breast cancer hospitalization and socioeconomic factors and soil heavy metal pollutants were evaluated with quasi-Poisson regression models and geographically weighted Poisson regressions (GWPR). Results The annual hospitalization rate for breast cancer was 101.40/100,000 in the studied area and the rate varied across different counties. Overall, hospitalization for breast cancer was associated with road density (β = 0.43, P = 0.02), urbanization (β = 0.02, P = 0.002) and soil cadmium (Cd) pollution (β = 0.01, P = 0.02). In the GWPR model, a stronger spatial association of Cd, road density and breast cancer hospitalization was found in the northeast regions of the study area while breast cancer hospitalization was mainly related to urbanization in the western regions. Conclusions Soil Cd pollution, road density, and urbanization were associated with breast cancer hospitalization in different regions. Findings in this study might provide valuable information for healthcare policies and intervention strategies for breast cancer.

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Section: Discussionmentioning

confidence: 99%

Spatial patterns and the associated factors for breast cancer hospitalization in the rural population of Fujian Province, China

et al. 2023

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show abstract

“…Cd have been classi ed as known and suspected carcinogens (IARC, 2011). The increased hospitalization for breast cancer in regions with higher Cd pollution is biologically plausible as Cd is involved in the carcinogenesis of breast cancer by activating ER (Ali et al, 2012;Ali et al, 2016;Kluxen et al, 2013), inducing cell proliferation, differentiation, and apoptosis (Huff et al, 2007), and modulating gene expression. Epidemiological studies also indicated that urinary Cd levels were higher in breast cancer patients than normal controls (McElroy et al, 2006;Nagata et al, 2013), while breast cancer tissue had four times higher Cd levels than surrounding healthy tissue.…”

Section: Discussionmentioning

confidence: 99%

Spatial patterns and the associated factors for breast cancer hospitalization in Fujian Province, China

Song

Huang

Wei

et al. 2022

Preprint

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Despite the known increasing incidence of breast cancer in China, evidence on the spatial pattern of hospitalization for breast cancer is scarce. This study aimed to describe the disparity of breast cancer hospitalization in Southeast China and to explore the impacts from socioeconomic factors and heavy metal pollution in soil. This study was conducted using the New Rural Cooperative Medical Scheme (NRCMS) claims data covering 25.52 million female rural residents from 73 counties in Southeast China during 2015–2016. The associations between breast cancer hospitalization and socioeconomic factors and soil heavy metals pollutants were evaluated with quasi-Poisson regression models and geographically weighted Poisson regressions (GWPR).The annual hospitalization rate for breast cancer was 101.40/100,000 in the studied area and the rate varied across different counties. Overall, hospitalization for breast cancer was associated with road density (β = 0.43, P = 0.02), urbanization (β = 0.02, P = 0.002) and soil cadmium (Cd) pollution (β = 0.01, P = 0.02). In the GWPR model, a stronger spatial association of Cd, road density and breast cancer hospitalization was found in the northeast regions of the study area while breast cancer hospitalization was mainly related to urbanization in the western regions. Soil Cd pollution, road density, and urbanization were associated with breast cancer hospitalization in different regions. Findings in this study might provide valuable information for healthcare policies and intervention strategies for breast cancer.

show abstract

“…Cd have been classi ed as known and suspected carcinogens [50] . The increased hospitalization for breast cancer in regions with higher Cd pollution is biologically plausible as Cd is involved in the carcinogenesis of breast cancer by activating ER [51][52][53] , inducing cell proliferation, differentiation, and apoptosis [54] , and modulating gene expression. Epidemiological studies also indicated that urinary Cd levels were higher in breast cancer patients than normal controls [55,56] , while breast cancer tissue had four times higher Cd levels than surrounding healthy tissue.…”

Section: Discussionmentioning

confidence: 99%

Spatial patterns and the associated factors for breast cancer hospitalization in Fujian Province, China

Song

Huang

Wei

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Despite the known increasing incidence of breast cancer in China, evidence on the spatial pattern of hospitalization for breast cancer is scarce. This study aimed to describe the disparity of breast cancer hospitalization in Southeast China and to explore the impacts from socioeconomic factors and heavy metal pollution in soil. Methods This study was conducted using the New Rural Cooperative Medical Scheme (NRCMS) claims data covering 25.52 million female rural residents from 73 counties in Southeast China during 2015–2016. The associations between breast cancer hospitalization and socioeconomic factors and soil heavy metals pollutants were evaluated with quasi-Poisson regression models and geographically weighted Poisson regressions (GWPR). Results The annual hospitalization rate for breast cancer was 101.40/100,000 in the studied area and the rate varied across different counties. Overall, hospitalization for breast cancer was associated with road density (β = 0.43, P = 0.02), urbanization (β = 0.02, P = 0.002) and soil cadmium (Cd) pollution (β = 0.01, P = 0.02). In the GWPR model, a stronger spatial association of Cd, road density and breast cancer hospitalization was found in the northeast regions of the study area while breast cancer hospitalization was mainly related to urbanization in the western regions. Conclusions Soil Cd pollution, road density, and urbanization were associated with breast cancer hospitalization in different regions. Findings in this study might provide valuable information for healthcare policies and intervention strategies for breast cancer.

show abstract

From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo

Cited by 7 publications

References 27 publications

Spatial patterns and the associated factors for breast cancer hospitalization in the rural population of Fujian Province, China

Spatial patterns and the associated factors for breast cancer hospitalization in the rural population of Fujian Province, China

Spatial patterns and the associated factors for breast cancer hospitalization in Fujian Province, China

Spatial patterns and the associated factors for breast cancer hospitalization in Fujian Province, China

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