From polymer blends to a block copolymer: Ring-opening polymerization of L-lactide/ε-caprolactone eutectic system

Low-Temperature and Solventless Ring-Opening Polymerization of Eutectic Mixtures of l-Lactide and Lactones for Biodegradable Polyesters

“…We followed the methodology described in our previous work with the DESm of LLA−CL at the same molar ratio. 6 The overall reaction is depicted in Figure S7 in the Supporting Information. To ensure high conversions, the reaction was carried out for 24 h. Once the polymerization was completed, the purified products were studied by 1 H NMR spectroscopy.…”

“…2−4 Strategies for coupling the properties of PLLA with polycaprolactone (PCL) are currently the subject of intense research. 5,6 For instance, blending or copolymerizing PCL with PLLA to improve the strength and elongation properties of the resulting polymers without loss in biodegradability has been previously reported. 7 PLLA and polylactones are predominantly synthesized through ring-opening polymerization (ROP) of lactide and lactones, respectively.…”

“…Polylactones are biodegradable and biocompatible polyesters used in biomedicine and are usually obtained from monomers such as ε-caprolactone (CL), δ-valerolactone (VAL), δ-decalactone (DCL), and dodecalactone (DOCL). − Strategies for coupling the properties of PLLA with polycaprolactone (PCL) are currently the subject of intense research. , For instance, blending or copolymerizing PCL with PLLA to improve the strength and elongation properties of the resulting polymers without loss in biodegradability has been previously reported …”

Lipase‐Catalysed Polymerization of Eutectic Mixtures

“…[25] In 2022, Castillo-Santillan et al reported the synthesis of polyesters based on poly(llactide) and poly(caprolactone), through an alternative method employing ionic liquids and non-ionic DES monomers, using a chemical catalyst. [26] In this work, we propose the solvent-free synthesis of small polymers through lipase-catalyzed esterification of NADESnatural eutectic mixtures' components. For the first time, monomers like oxalic acid, citric acid, glycerol, and sodium DLlactate will be used as substrates of lipase for the synthesis of polyesters.…”

“…In 2022, Castillo‐Santillan et al. reported the synthesis of polyesters based on poly( l ‐lactide) and poly(caprolactone), through an alternative method employing ionic liquids and non‐ionic DES monomers, using a chemical catalyst [26] …”