From Pilot Plant to Manufacturing: Effect of Scale‐Up on Operation of Jacketed Reactors

Abstract

Temperature control for laboratory reactors is typically easy because of high heat transfer area – reactor volume ratios, which do not require large driving forces for heat transfer from the reactor to the jacket. Pilot‐and full‐scale reactors, however, often have a limited heat transfer capability. This article provides an overview of scale‐up considerations involved as one moves from bench‐scale reaction calorimetry to larger scale pilot plant and production reactors.